Imperial College London
Portrait Picture

ProfessorPaoloMuraro

Faculty of Medicine, Department of Brain Sciences

Professor of Neurology - Neuroimmunology and Immunotherapy
 
 
 
//

Contact

 

p.muraro Website

 
 
//

Assistant

 

Mrs Gearoidin Beazley +44 (0)20 7594 7047

 
//

Location

 

E415Burlington DanesHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Cencioni:2017:10.1111/imm.12808,
author = {Cencioni, MT and Magliozzi, R and Nicholas, R and Ali, R and Malik, O and Reynolds, R and Borsellino, G and Battistini, L and Muraro, PA},
doi = {10.1111/imm.12808},
journal = {Immunology},
pages = {660--676},
title = {Programmed death 1 is highly expressed on CD8(+) CD57(+) T cells in patients with stable multiple sclerosis and inhibits their cytotoxic response to Epstein-Barr virus.},
url = {http://dx.doi.org/10.1111/imm.12808},
volume = {152},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Growing evidence points to a deregulated response to Epstein-Barr virus (EBV) in the central nervous system of patients with multiple sclerosis (MS) as a possible cause of disease. We have investigated the response of a subpopulation of effector CD8(+) T cells to EBV in 36 healthy donors and in 35 patients with MS in active and inactive disease. We have measured the expression of markers of degranulation, the release of cytokines, cytotoxicity and the regulation of effector functions by inhibitory receptors, such as programmed death 1 (PD-1) and human inhibitor receptor immunoglobulin-like transcript 2 (ILT2). We demonstrate that polyfunctional cytotoxic CD8(+) CD57(+) T cells are able to kill EBV-infected cells in healthy donors. In contrast, an anergic exhaustion-like phenotype of CD8(+) CD57(+) T cells with high expression of PD-1 was observed in inactive patients with MS compared with active patients with MS or healthy donors. Detection of CD8(+) CD57(+) T cells in meningeal inflammatory infiltrates from post-mortem MS tissue confirmed the association of this cell phenotype with the disease pathological process. The overall results suggest that ineffective immune control of EBV in patietns with MS during remission may be one factor preceding and enabling the reactivation of the virus in the central nervous system and may cause exacerbation of the disease.
AU  - Cencioni,MT
AU  - Magliozzi,R
AU  - Nicholas,R
AU  - Ali,R
AU  - Malik,O
AU  - Reynolds,R
AU  - Borsellino,G
AU  - Battistini,L
AU  - Muraro,PA
DO  - 10.1111/imm.12808
EP  - 676
PY  - 2017///
SN  - 0019-2805
SP  - 660
TI  - Programmed death 1 is highly expressed on CD8(+) CD57(+) T cells in patients with stable multiple sclerosis and inhibits their cytotoxic response to Epstein-Barr virus.
T2  - Immunology
UR  - http://dx.doi.org/10.1111/imm.12808
UR  - http://hdl.handle.net/10044/1/51604
VL  - 152
ER  -
Download