Imperial College London
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ProfessorPaoloMuraro

Faculty of Medicine, Department of Brain Sciences

Professor of Neurology - Neuroimmunology and Immunotherapy
 
 
 
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Contact

 

p.muraro Website

 
 
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Assistant

 

Mrs Gearoidin Beazley +44 (0)20 7594 7047

 
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Location

 

E415Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mancardi:2018:10.1177/1352458517742532,
author = {Mancardi, G and Sormani, MP and Muraro, PA and Boffa, G and Saccardi, R},
doi = {10.1177/1352458517742532},
journal = {Multiple Sclerosis},
pages = {245--255},
title = {Intense immunosuppression followed by autologous haematopoietic stem cell transplantation as a therapeutic strategy in aggressive forms of multiple sclerosis},
url = {http://dx.doi.org/10.1177/1352458517742532},
volume = {24},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In the majority of relapsing multiple sclerosis patients, the disease can be quite easily controlled by already available, approved therapies. There are, however, some aggressive cases who continue to have clinical and magnetic resonance imaging (MRI) activity in spite of the treatment. These are the cases who may now receive benefit from intense immunosuppression followed by autologous haematopoietic stem cell transplantation (aHSCT). In this review, we describe the method and the rationale of aHSCT, the more recently published studies that demonstrate its efficacy in selected multiple sclerosis cases, the problems related to safety and the transplant-related mortality risk of the procedure. A description of the ideal patient who can take advantage of aHSCT is outlined and, finally, the ongoing studies which are near to completion or are close to starting are briefly reported.
AU  - Mancardi,G
AU  - Sormani,MP
AU  - Muraro,PA
AU  - Boffa,G
AU  - Saccardi,R
DO  - 10.1177/1352458517742532
EP  - 255
PY  - 2018///
SN  - 1352-4585
SP  - 245
TI  - Intense immunosuppression followed by autologous haematopoietic stem cell transplantation as a therapeutic strategy in aggressive forms of multiple sclerosis
T2  - Multiple Sclerosis
UR  - http://dx.doi.org/10.1177/1352458517742532
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000429327000002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/60513
VL  - 24
ER  -
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