Imperial College London

ProfessorPetrosNihoyannopoulos

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 3313 8156p.nihoyannopoulos

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

642 results found

Filippou CD, Thomopoulos CG, Kouremeti MM, Sotiropoulou LI, Nihoyannopoulos PI, Tousoulis DM, Tsioufis CPet al., 2021, Mediterranean diet and blood pressure reduction in adults with and without hypertension: A systematic review and meta-analysis of randomized controlled trials., Clin Nutr, Vol: 40, Pages: 3191-3200

BACKGROUND & AIMS: It is unclear whether the Mediterranean diet (MedDiet) has a favorable effect on blood pressure (BP) levels because among randomized controlled trials (RCTs) investigating the MedDiet-mediated BP reduction significant methodological and clinical differences are observed. The purpose of this study was to comprehensively assess the MedDiet BP-effect compared to the usual diet or another dietary intervention (e.g. low-fat diet) in adults with and without hypertension, accounting for methodological and clinical confounders. METHODS: We systematically searched Medline and the Cochrane Collaboration Library databases and identified 35 RCTs (13,943 participants). Random-effects model was used to calculate the mean attained systolic BP (SBP) and diastolic BP (DBP) differences during follow-up. Subgroup and meta-regression analyses were also conducted. RESULTS: Compared to the usual diet and all other active intervention diets the MedDiet reduced SBP and DBP (difference in means: -1.5 mm Hg; 95% CI: -2.8, -0.1; P = 0.035, and -0.9 mm Hg; 95% CI: -1.5, -0.3; P = 0.002, respectively). Compared only to the usual diet the MedDiet reduced SBP and DBP, while compared to all other active intervention diets or only to the low-fat diet the MedDiet did not reduce SBP and DBP. The MedDiet reduced DBP levels to a higher extent in trials with mean baseline SBP ≥130 mm Hg, while both SBP and DBP were reduced more in trials with a mean follow-up period ≥16 weeks. The quality of evidence was rated as moderate for both outcomes according to the grading of recommendations, assessment, development and evaluation (GRADE) approach. CONCLUSIONS: The adoption of the MedDiet was accompanied by a relatively small, but yet significant BP reduction, while higher baseline SBP levels and longer follow-up duration enhanced the BP-lowering effect of the intervention. This meta-analysis was registered in the Inter

Journal article

Bazoukis G, Thomopoulos C, Tse G, Tsioufis K, Nihoyannopoulos Pet al., 2021, Global longitudinal strain predicts responders after cardiac resynchronization therapy-a systematic review and meta-analysis, HEART FAILURE REVIEWS, ISSN: 1382-4147

Journal article

Mikhail G, Khawaja SA, Mohan P, Jabbour R, Bampouri T, Bowsher G, Hassan AMM, Huq F, Baghdasaryan L, Wang B, Sethi A, Sen S, Petraco R, Ruparelia N, Nijjer S, Malik IS, Foale R, Bellamy M, Kooner J, Rana BS, Cole G, Sutaria N, Kanaganayagam G, Nihoyannopoulos P, Fox K, Plymen CM, Pabari P, Howard L, Davies R, Hajoi G, Lo Giudice F, Kanagaratnam P, Anderson J, Chukwuemeka A, Khamis R, Varnava A, Baker CSR, Francis D, Asaria P, Al-Lamee Ret al., 2021, COVID-19 and its impact on the cardiovascular system, Open Heart, Vol: 8, Pages: 1-9, ISSN: 2053-3624

Objectives: The clinical impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has varied across countries with varying cardiovascular manifestations. We review the cardiac presentations, in-hospital outcomes and development of cardiovascular complications in the initial cohort of SARS-CoV-2 positive patients at Imperial College Healthcare NHS Trust, United Kingdom.Methods: We retrospectively analysed 498 COVID-19 positive adult admissions to our institute from 7th March to 7th April 2020. Patient data was collected for baseline demographics, co-morbidities and in-hospital outcomes, especially relating to cardiovascular intervention.Results:Mean age was 67.4±16.1 years and 62.2%(n=310) were male. 64.1%(n=319) of our cohort had underlying cardiovascular disease (CVD) with 53.4%(n=266) having hypertension. 43.2%(n=215) developed acute myocardial injury. Mortality was significantly increased in those patients with myocardial injury (47.4% vs 18.4%,p<0.001). Only 4 COVID-19 patients had invasive coronary angiography,2 underwent percutaneous coronary intervention and 1 required a permanent pacemaker implantation. 7.0%(n=35) of patients had an inpatient echocardiogram. Acute myocardial injury (OR 2.39,1.31-4.40,p=0.005) and history of hypertension (OR 1.88 ,1.01-3.55,p=0.049) approximately doubled the odds of in-hospital mortality in patients admitted with COVID-19 after other variables had been controlled for.Conclusion:Hypertension, pre-existing CVD and acute myocardial injury were associated with increased in-hospital mortality in our cohort of COVID-19 patients. However, only a low number of patients required invasive cardiac intervention.

Journal article

Cambronero-Cortinas E, Moratalla-Haro P, Nihoyannopoulos P, 2021, Uncommon cardiac involvement of hypereosinophylic syndrome, REVISTA ESPANOLA DE CARDIOLOGIA, Vol: 74, Pages: 183-183, ISSN: 0300-8932

Journal article

Ramlakhan KP, Tobler D, Greutmann M, Schwerzmann M, Baris L, Yetman AT, Nihoyannopoulos P, Manga P, Boersma E, Maggioni AP, Johnson MR, Hall R, Roos-Hesselink JWet al., 2021, Pregnancy outcomes in women with aortic coarctation, HEART, Vol: 107, Pages: 290-298, ISSN: 1355-6037

Journal article

Cambronero-Cortinas E, Moratalla-Haro P, Nihoyannopoulos P, 2021, Uncommon cardiac involvement of hypereosinophylic syndrome, Revista Espanola de Cardiologia, Vol: 74, ISSN: 0300-8932

Journal article

Celutkiene J, Pudil R, Lopez-Fernandez T, Grapsa J, Nihoyannopoulos P, Bergler-Klein J, Cohen-Solal A, Farmakis D, Tocchetti CG, von Haehling S, Barberis V, Flachskampf FA, Ceponlene J, Haegler-Laube E, Suter T, Lapinskas T, Prasad S, de Boer RA, Wechalekar K, Anker MS, Iakobishvili Z, Bucciarelli-Ducci C, Schulz-Menger J, Cosyns B, Gaemperli O, Belenkov Y, Hulot J-S, Galderisi M, Lancellotti P, Bax J, Marwick TH, Chioncel O, Jaarsma T, Mullens W, Piepoli M, Thum T, Heymans S, Mueller C, Moura B, Ruschitzka F, Zamorano JL, Rosano G, Coats AJS, Asteggiano R, Seferovic P, Edvardsen T, Lyon ARet al., 2021, Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC) (vol 22, pg 1504, 2020), EUROPEAN JOURNAL OF HEART FAILURE, Vol: 23, Pages: 345-345, ISSN: 1388-9842

Journal article

Naderi H, Robinson S, Swaans MJ, Bual N, Cheung W-S, Reid L, Shun-Shin M, Asaria P, Pabari P, Cole G, Kanaganayagam GS, Sutaria N, Bellamy M, Fox K, Nihoyannopoulos P, Petraco R, Al-Lamee R, Nijjer SS, Sen S, Ruparelia N, Baker C, Mikhail G, Malik I, Khamis R, Varnava A, Francis D, Mayet J, Rana Bet al., 2021, Adapting the role of handheld echocardiography during the COVID-19 pandemic: A practical guide, PERFUSION-UK, ISSN: 0267-6591

Journal article

Sachpekidis V, Adamopoulos C, Datsios A, Mosialos L, Stamatiadis N, Gogos C, Poulianitis V, Galanos O, Stratilati S, Styliadis I, Nihoyannopoulos Pet al., 2020, A tricky case of cardiogenic shock: Diagnostic challenges in the COVID-19 era, CLINICAL CASE REPORTS, Vol: 9, Pages: 420-424, ISSN: 2050-0904

Journal article

Ricci P, Ostenfeld E, Flick C, West C, Babu-Narayan S, Nihoyannopoulos P, Li Wet al., 2020, Assessment of biventricular function using advanced echocardiography in patients with Ebstein's anomaly pre and post-tricuspid valve surgery, Euroecho 2020, Publisher: OXFORD UNIV PRESS, Pages: 147-147, ISSN: 0195-668X

Conference paper

Tsampasian V, Panoulas V, Jabbour RJ, Ruparelia N, Malik IS, Hadjiloizou N, Frame A, Sen S, Sutaria N, Mikhail GW, Nihoyannopoulos Pet al., 2020, Left ventricular speckle tracking echocardiographic evaluation before and after TAVI, ECHO RESEARCH AND PRACTICE, Vol: 7, Pages: 29-38, ISSN: 2055-0464

Journal article

Filippou CD, Tsioufis CP, Thomopoulos CG, Mihas CC, Dimitriadis KS, Sotiropoulou LI, Chrysochoou CA, Nihoyannopoulos PI, Tousoulis DMet al., 2020, Dietary Approaches to Stop Hypertension (DASH) Diet and Blood Pressure Reduction in Adults with and without Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials., Adv Nutr, Vol: 11, Pages: 1150-1160

The Dietary Approaches to Stop Hypertension (DASH) diet is recognized as an effective dietary intervention to reduce blood pressure (BP). However, among randomized controlled trials (RCTs) investigating the DASH diet-mediated BP reduction, there are significant methodological and clinical differences. The purpose of this study was to comprehensively assess the DASH diet effect on BP in adults with and without hypertension, accounting for underlying methodological and clinical confounders. We systematically searched Medline and the Cochrane Collaboration Library databases and identified 30 RCTs (n = 5545 participants) that investigated the BP effects of the DASH diet compared with a control diet in hypertensive and nonhypertensive adults. Both random-effects and fixed-effect models were used to calculate the mean attained systolic BP (SBP) and diastolic BP (DBP) differences during follow-up. Subgroup and meta-regression analyses were also conducted. Compared with a control diet, the DASH diet reduced both SBP and DBP (difference in means: -3.2 mm Hg; 95% CI: -4.2, -2.3 mm Hg; P < 0.001, and -2.5 mm Hg; 95% CI: -3.5, -1.5 mm Hg; P < 0.001, respectively). Hypertension status did not modify the effect on BP reduction. The DASH diet compared with a control diet reduced SBP levels to a higher extent in trials with sodium intake >2400 mg/d than in trials with sodium intake ≤2400 mg/d, whereas both SBP and DBP were reduced more in trials with mean age <50 y than in trials of older participants. The quality of evidence was rated as moderate for both outcomes according to the Grading of Recommendations, Assessment, Development, and Evaluation approach. The adoption of the DASH diet was accompanied by significant BP reduction in adults with and without hypertension, although higher daily sodium intake and younger age enhanced the BP-lowering effect of the intervention. This meta-analysis was registered at www.crd.york.ac.uk/pro

Journal article

Celutkiene J, Pudil R, Lopez-Fernandez T, Grapsa J, Nihoyannopoulos P, Bergler-Klein J, Cohen-Solal A, Farmakis D, Tocchetti CG, von Haehling S, Barberis V, Flachskampf FA, Ceponiene I, Haegler-Laube E, Suter T, Lapinskas T, Prasad S, de Boer RA, Wechalekar K, Anker MS, Iakobishvili Z, Bucciarelli-Ducci C, Schulz-Menger J, Cosyns B, Gaemperli O, Belenkov Y, Hulot J-S, Galderisi M, Lancellotti P, Bax J, Marwick TH, Chioncel O, Jaarsma T, Mullens W, Piepoli M, Thum T, Heymans S, Mueller C, Moura B, Ruschitzka F, Zamorano JL, Rosano G, Coats AJS, Asteggiano R, Seferovic P, Edvardsen T, Lyon ARet al., 2020, Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC), EUROPEAN JOURNAL OF HEART FAILURE, Vol: 22, Pages: 1504-1524, ISSN: 1388-9842

Journal article

Panoulas VF, Chandrasekhar J, Busi G, Ruparelia N, Zhang Z, Mehilli J, Sartori S, Lefevre T, Presbitero P, Capranzano P, Tchetche D, Iadanza A, Sardella G, Van Mieghem NM, Meliga E, Dumonteil N, Fraccaro C, Trabattoni D, Sharma S, Ferrer-Gracia M-C, Naber CK, Kievit PC, Snyder C, Sutaria N, Sen S, Malik IS, Morice M-C, Nihoyannopoulos P, Petronio AS, Mehran R, Chieffo A, Mikhail GWet al., 2020, Prevalence, predictors, and outcomes of patient prosthesis mismatch in women undergoingTAVIfor severe aortic stenosis: Insights from theWIN-TAVIregistry, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 97, Pages: 516-526, ISSN: 1522-1946

Journal article

Garcia-Gonzalez C, Georgiopoulos G, Azim SA, Macaya F, Kametas N, Nihoyannopoulos P, Nicolaides KH, Charakida Met al., 2020, Maternal Cardiac Assessment at 35 to 37 Weeks Improves Prediction of Development of Preeclampsia, HYPERTENSION, Vol: 76, Pages: 514-522, ISSN: 0194-911X

Journal article

Grapsa J, Tan TC, Nunes MCP, O'Regan DP, Durighel G, Howard LSGE, Gibbs JSR, Nihoyannopoulos Pet al., 2020, Prognostic impact of right ventricular mass change in patients with idiopathic pulmonary arterial hypertension, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 304, Pages: 172-174, ISSN: 0167-5273

Journal article

Nel S, Nihoyannopoulos P, Libhaber E, Essop MR, dos Santos CF, Matioda H, Waterworth C, Grinter S, Meel R, Peters Fet al., 2020, Echocardiographic Indices of the Left and Right Heart in a Normal Black African Population, JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, Vol: 33, Pages: 358-367, ISSN: 0894-7317

Journal article

Kyung S, Goldberg A, Feinstein S, Wilson S, Mulvagh S, Nihoyannopoulos Pet al., 2020, The 34th Annual Advances in Contrast Ultrasound International Bubble Conference, Chicago 2019: synopsis and take-home messages, ECHO RESEARCH AND PRACTICE, Vol: 7, Pages: M1-M5, ISSN: 2055-0464

Journal article

Celutkiene J, Lainscak M, Anderson L, Gayat E, Grapsa J, Harjola V-P, Manka R, Nihoyannopoulos P, Filardi PP, Vrettou R, Anker SD, Filippatos G, Mebazaa A, Metra M, Piepoli M, Ruschitzka F, Luis Zamorano J, Rosano G, Seferovic Pet al., 2020, Imaging in patients with suspected acute heart failure: timeline approach position statement on behalf of the Heart Failure Association of the European Society of Cardiology, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 22, Pages: 181-195, ISSN: 1388-9842

Journal article

Keramida K, Lazaros G, Nihoyannopoulos P, 2020, Right ventricular involvement in hypertrophic cardiomyopathy: Patterns and implications, HELLENIC JOURNAL OF CARDIOLOGY, Vol: 61, Pages: 3-8, ISSN: 1109-9666

Journal article

Alfarih M, Leu C, Moon J, Hughes A, Nihoyannopoulos P, Captur Get al., 2019, Echocardiographic Assessment of Left Ventricular Function in Patients with Aortic Stenosis and the short-term effects after intervention, Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 507-507, ISSN: 0195-668X

Conference paper

Vrettos A, Al Saikhan L, Matiti L, Plymen C, Low B, Nihoyannopoulos Pet al., 2019, Left atrial strain parameters predict clinical outcomes in patients with HFmrEF and HFpEF, Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 1423-1423, ISSN: 0195-668X

Conference paper

Augustine DX, Coates-Bradshaw LD, Willis J, Harkness A, Ring L, Grapsa J, Coghlan G, Kaye N, Oxborough D, Robinson S, Sandoval J, Rana BS, Siva A, Nihoyannopoulos P, Howard LS, Fox K, Bhattacharyya S, Sharma V, Steeds RP, Mathew Tet al., 2019, Echocardiographic assessment of pulmonary hypertension: a guideline protocol from the British Society of Echocardiography (vol 5, pg G11, 2018), ECHO RESEARCH AND PRACTICE, Vol: 6, Pages: X1-X1, ISSN: 2055-0464

Journal article

Triposkiadis F, Butler J, Abboud FM, Armstrong PW, Adamopoulos S, Atherton JJ, Backs J, Bauersachs J, Burkhoff D, Bonow RO, Chopra VK, de Boer RA, de Windt L, Hamdani N, Hasenfuss G, Heymans S, Hulot J-S, Konstam M, Lee RT, Linke WA, Lunde IG, Lyon AR, Maack C, Mann DL, Mebazaa A, Mentz RJ, Nihoyannopoulos P, Papp Z, Parissis J, Pedrazzini T, Rosano G, Rouleau J, Seferovic PM, Shah AM, Starling RC, Tocchetti CG, Trochu J-N, Thum T, Zannad F, Brutsaert DL, Segers VF, De Keulenaer GWet al., 2019, The continuous heart failure spectrum: moving beyond an ejection fraction classification, European Heart Journal, Vol: 40, Pages: 2155-2163, ISSN: 1522-9645

Randomized clinical trials initially used heart failure (HF) patients with low left ventricular ejection fraction (LVEF) to select study populations with high risk to enhance statistical power. However, this use of LVEF in clinical trials has led to oversimplification of the scientific view of a complex syndrome. Descriptive terms such as 'HFrEF' (HF with reduced LVEF), 'HFpEF' (HF with preserved LVEF), and more recently 'HFmrEF' (HF with mid-range LVEF), assigned on arbitrary LVEF cut-off points, have gradually arisen as separate diseases, implying distinct pathophysiologies. In this article, based on pathophysiological reasoning, we challenge the paradigm of classifying HF according to LVEF. Instead, we propose that HF is a heterogeneous syndrome in which disease progression is associated with a dynamic evolution of functional and structural changes leading to unique disease trajectories creating a spectrum of phenotypes with overlapping and distinct characteristics. Moreover, we argue that by recognizing the spectral nature of the disease a novel stratification will arise from new technologies and scientific insights that will shape the design of future trials based on deeper understanding beyond the LVEF construct alone.

Journal article

Steeds RP, Wheeler R, Bhattacharyya S, Reiken J, Nihoyannopoulos P, Senior R, Monaghan MJ, Sharma Vet al., 2019, Stress echocardiography in coronary artery disease: a practical guideline from the British Society of Echocardiography, ECHO RESEARCH AND PRACTICE, Vol: 6, Pages: G17-G33, ISSN: 2055-0464

Journal article

Papazoglou S-M, Jaffer U, Aslam M, Trikas A, Pantos C, Toutouzas K, Nihoyannopoulos P, Stefanadis CH, Tousoulis D, Standfield Net al., 2019, Do NT-proBNP levels depend on the diameter of abdominal aorta in patients with chronic HFpEF and AAA?, European Heart failure meeting, Publisher: WILEY, Pages: 51-52, ISSN: 1388-9842

Conference paper

Vrettos A, Al Saikhan L, Plymen C, Chilcott J, Matiti L, Nihoyannopoulos Pet al., 2019, Left atrial function in HFpEF and HFmrEF patients; relation to pulmonary artery systolic pressure, European Heart Failure meeting, Publisher: WILEY, Pages: 227-228, ISSN: 1388-9842

Conference paper

Papazoglou S-MS-M, Jaffer U, Aslam M, Richter D, Trikas A, Pantos C, Toutouzas K, Nihoyannopoulos P, Standfield NJ, Tousoulis Det al., 2019, Does PSV in ICA independently predict plasma levels of NT-proBNP in patients with HFrEF diabetic cardiomyopathy and ipsilateral carotid artery disease?, European Heart Failure meeting, Publisher: WILEY, Pages: 205-206, ISSN: 1388-9842

Conference paper

Keramida K, Farmakis D, Bingcang J, Sulemane S, Sutherland S, Bingcang RA, Ramachandran K, Tzavara C, Charalampopoulos G, Filippiadis D, Kouris N, Nihoyannopoulos Pet al., 2019, Longitudinal changes of right ventricular deformation mechanics during trastuzumab therapy in breast cancer patients, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 21, Pages: 529-535, ISSN: 1388-9842

Journal article

Ikonomidis I, Aboyans V, Blacher J, Brodmann M, Brutsaert DL, Chirinos JA, De Carlo M, Delgado V, Lancellotti P, Lekakis J, Mohty D, Nihoyannopoulos P, Parissis J, Rizzoni D, Ruschitzka F, Seferovic P, Stabile E, Tousoulis D, Vinereanu D, Vlachopoulos C, Vlastos D, Xaplanteris P, Zimlichman R, Metra Met al., 2019, The role of ventricular-arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions. A consensus document of the European Society of Cardiology Working Group on Aorta & Peripheral Vascular Diseases, European Association of Cardiovascular Imaging, and Heart Failure Association, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 21, Pages: 402-424, ISSN: 1388-9842

Journal article

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