ProfessorPetrosNihoyannopoulos

Katsi V, Felekos I, Siristatidis C, Kasioni S, Drakontaidis A, Farmakides G, Makris T, Aggeli C, Nihoyannopoulos P, Tousoulis D, Kallikazaros Iet al., 2015, Preeclampsia: What Does the Father Have to Do with It?, Curr Hypertens Rep, Vol: 17

Preeclampsia (PE) is one of the leading causes of maternal and fetal morbidity and mortality, with incidence rates ranging between 2 and 5 % in the Western World. The exact causes of the disease remain largely unknown, because of the complex pathophysiologic mechanisms involved in the process. Genetic, environmental, and epigenetic parameters have been implicated by various authors as culprits for the pathogenesis of PE. Recent reports in the literature highlight the paternal role. Still, the exact extent and mechanism remain elusive. In this systematic review, we attempt to present data regarding the paternal role in a concise and comprehensive manner.

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Yeh JS-M, Sennoga CA, McConnell E, Eckersley R, Tang M-X, Nourshargh S, Seddon JM, Haskard DO, Nihoyannopoulos Pet al., 2015, A targeting microbubble for ultrasound molecular imaging, PLoS ONE, Vol: 10, ISSN: 1932-6203

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Erbel R, Aboyans V, Boileau C, Bossone E, Di Bartolomeo R, Eggebrecht H, Evangelista A, Falk V, Frank H, Gaemperli O, Grabenwöger M, Haverich A, Iung B, Manolis AJ, Meijboom F, Nienaber CA, Roffi M, Rousseau H, Sechtem U, Sirnes PA, von Allmen RS, Vrints CJM, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol Ç, Fagard R, Ferrari R, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker Set al., 2015, 2014 ESC guidelines on the diagnosis and treatment of aortic diseases, Russian Journal of Cardiology, Vol: 123, Pages: 7-72, ISSN: 1560-4071

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• Citations: 13

Grapsa J, Nunes MCP, Tan TC, Cabrita IZ, Coulter T, Smith BCF, Dawson D, Gibbs JSR, Nihoyannopoulos Pet al., 2015, Echocardiographic and Hemodynamic Predictors of Survival in Precapillary Pulmonary Hypertension Seven-Year Follow-Up, CIRCULATION-CARDIOVASCULAR IMAGING, Vol: 8, ISSN: 1941-9651

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• Citations: 31

Nihoyannopoulos P, 2015, In pursuit of the holy grail, JACC. Cardiovascular Imaging, Vol: 8, Pages: 523-525, ISSN: 1876-7591

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Panoulas VF, Sulemane S, Konstantinou K, Bratsas A, Elliott SJ, Dawson D, Frankel AH, Nihoyannopoulos Pet al., 2015, Early detection of subclinical left ventricular myocardial dysfunction in patients with chronic kidney disease, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol: 16, Pages: 539-548, ISSN: 2047-2404

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• Citations: 34

Afilalo J, Grapsa J, Nihoyannopoulos P, Beaudoin J, Gibbs JSR, Channick RN, Langleben D, Rudski LG, Hua L, Handschumacher MD, Picard MH, Levine RAet al., 2015, Leaflet Area as a Determinant of Tricuspid Regurgitation Severity in Patients With Pulmonary Hypertension, CIRCULATION-CARDIOVASCULAR IMAGING, Vol: 8, ISSN: 1941-9651

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• Citations: 33

Kleijn SA, Pandian NG, Thomas JD, de Isla LP, Kamp O, Zuber M, Nihoyannopoulos P, Forster T, Nesser H-J, Geibel A, Gorissen W, Zamorano JLet al., 2015, Normal reference values of left ventricular strain using three-dimensional speckle tracking echocardiography: results from amulticentre study, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol: 16, Pages: 410-416, ISSN: 2047-2404

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• Citations: 72

Windecker S, Kolh P, Alfonso F, Collet JP, Cremer J, Falk V, Filippatos G, Hamm C, Head SJ, Jüni P, Kappetein AP, Kastrati A, Knuuti J, Landmesser U, Laufer G, Neumann FJ, Richter DJ, Schauerte P, Uva MS, Stefanini GG, Taggart DP, Torracca L, Valgimigli M, Wijns W, Witkowski A, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol Ç, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Pepper J, Anyanwu A, Badimon L, Bauersachs J, Baumbach A, Beygui F, Bonaros N, De Carlo M, Dobrev D, Dunning J, Eeckhout E, Gielen S, Luckraz H, Mahrholdt H, Montalescot G, Paparella D, Rastan AJ, Sanmartín M, Sergeant P, Silber S, Ten Berg J, Thiele H, Van Geuns RJ, Wagner HO, Wassmann S, Wendler Oet al., 2015, Clinical practice guidelines of the ESC on myocardial revascularization, 2014, Revista Espanola de Cardiologia, Vol: 68, Pages: 144.e-144.e, ISSN: 0300-8932

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• Citations: 41

Salcedo EE, Carroll JD, Gillam LD, Koulogiannis K, Marcoff L, Grapsa J, Koutsogeorgis ID, Nihoyannopoulos P, Peters F, Khandheria BK, Kim MS, Kronzon I, Ruiz C, Perk G, Mendelson T, Alviar C, Saric M, Patel Aet al., 2015, Introduction, ASE’s Comprehensive Echocardiography, Pages: 809-848, ISBN: 9780323474481

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Yeh JSM, Nihoyannopoulos P, 2015, Molecular imaging of inflammation using echocardiography. Advances with the use of microbubbles, Introduction to Translational Cardiovascular Research, Pages: 465-501, ISBN: 9783319087979

Ultrasound molecular imaging uses microbubbles conjugated with targeting ligands. When administered intravenously these ’targeting bubbles’ attach to areas expressing the molecule of interest for ultrasound detection. The migration of this technology to human application has been limited by uncertainties regarding its safety and efficacy, including: (i) the lack of targeting bubbles that do not contain immunogenic (strept)avidin for ligand conjugation; (ii) the traditional use of high power ultrasound causing ’instantaneous’ bubble destruction, raising concerns about biosafety and rendering it not a real-time imaging technique (limiting bedside interpretation); (iii) the absence of robust molecular quantification methods, diminishing its potential diagnostic power. Progress has been made in all three areas recently. An example is molecular imaging of E-selectin expression for detecting endothelial activation or inflammation in the heart. Inflammation underlies important cardiovascular diseases, such as coronary atheromatous heart disease, myocarditis and heart transplant rejection. Endothelial activation occurs early in inflammation and E-selectin is classically expressed only on activated endothelial cells. E-selectin targeting bubbles, based on maleimide-thiol conjugation chemistry, were successfully engineered. They allowed high resolution real-time and quantitative ultrasound molecular imaging of the heart in mice. Future directions in the field includes establishing 3-D ultrasound molecular imaging, and therapies using targeting bubbles as vehicles for.

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Elliott PM, Anastasakis A, Borger MA, Borggrefe M, Cecchi F, Charron P, Hagege AA, Lafont A, Limongelli G, Mahrholdt H, McKenna WJ, Mogensen J, Nihoyannopoulos P, Nistri S, Pieper PG, Pieske B, Rapezzi C, Rutten FH, Tillmanns C, Watkins Het al., 2015, ESC 2014 clinical practice guidelines on the diagnosis and management of hypertrophic cardiomyopathy, Revista Espanola de Cardiologia, Vol: 68, Pages: 63.e1-63.e5, ISSN: 0300-8932

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• Citations: 9

Grapsa J, Cabrita IZ, Jakaj G, Ntalarizou E, Serapheim A, Demir OM, Smith B, Dawson D, Momin A, Punjabi PP, Anagnostopoulos CE, Nihoyannopoulos Pet al., 2015, Strain balance of papillary muscles as a prerequisite for successful mitral valve repair in patients with mitral valve prolapse due to fibroelastic deficiency, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol: 16, Pages: 53-61, ISSN: 2047-2404

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• Citations: 3

Smith BCF, Dobson G, Nihoyannopoulos P, 2014, REPLY: Is 3-Dimensional Echocardiographic Area Strain Diagnostically Superior to Longitudinal and Circumferential Strain?, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 64, Pages: 2807-2808, ISSN: 0735-1097

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Kristensen SD, Knuuti J, Saraste A, Anker S, Bøtker HE, De Hert S, Ford I, González-Juanatey JR, Gorenek B, Heyndrickx GR, Hoeft A, Huber K, Iung B, Per Kjeldsen K, Longrois D, Lüscher TF, Pierard L, Pocock S, Price S, Roffi M, Sirnes PA, Sousa-Uva M, Voudris V, Funck-Brentano C, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Solca M, Brichant JF, De Robertis E, Langenecker SK, Wichelewski Jet al., 2014, 2014 ESC/ESA Clinical practice guidelines on noncardiac surgery: Cardiovascular assessment and management: Joint Working Group on non-cardiac surgery: Cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anesthesiology (ESA), Revista Espanola de Cardiologia, Vol: 67, Pages: e1-e43, ISSN: 0300-8932

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• Citations: 3

Charalampopoulos A, Howard LS, Tzoulaki I, Gin-Sing W, Grapsa J, Wilkins MR, Davies RJ, Nihoyannopoulos P, Connolly SB, Gibbs JSRet al., 2014, Response to pulmonary arterial hypertension drug therapies in patients with pulmonary arterial hypertension and cardiovascular risk factors, PULMONARY CIRCULATION, Vol: 4, Pages: 669-678, ISSN: 2045-8932

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• Citations: 17

Ruys TPE, Maggioni A, Johnson MR, Sliwa K, Tavazzi L, Schwerzmann M, Nihoyannopoulos P, Kozelj M, Marelli A, Elkayam U, Hall R, Roos-Hesselink JWet al., 2014, Cardiac medication during pregnancy, data from the ROPAC, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 177, Pages: 124-128, ISSN: 0167-5273

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• Citations: 71

Konstantinides SV, Torbicki A, Agnelli G, Danchin N, Fitzmaurice D, Galie N, Gibbs JSR, Huisman MV, Humbert M, Kucher N, Lang I, Lankeit M, Lekakis J, Maack C, Mayer E, Meneveau N, Perrier A, Pruszczyk P, Rasmussen LH, Schindler TH, Svitil P, Noordegraaf AV, Zamorano JL, Zompatori Met al., 2014, 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC), EUROPEAN HEART JOURNAL, Vol: 35, Pages: 3033-3080, ISSN: 0195-668X

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• Citations: 2244

Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, Evangelista A, Falk V, Frank H, Gaemperli O, Grabenwöger M, Haverich A, Iung B, Manolis AJ, Meijboom F, Nienaber CA, Roffi M, Rousseau H, Sechtem U, Sirnes PA, Allmen RSV, Vrints CJM, ESC Committee for Practice Guidelineset al., 2014, 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC)., Eur Heart J, Vol: 35, Pages: 2873-2926

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Lancellotti P, Habib G, Badano L, Fraser A, Nihoyannopoulos P, Pinto F, Zamorano J-L, Distante A, Founder E, Maurer Get al., 2014, J.R.T.C. Roelandt (November 12, 1938-August 31, 2014)., Eur Heart J Cardiovasc Imaging, Vol: 15

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Popescu BA, Stefanidis A, Nihoyannopoulos P, Fox KF, Ray S, Cardim N, Rigo F, Badano LP, Fraser AG, Pinto F, Luis Zamorano J, Habib G, Maurer G, Lancellotti Pet al., 2014, Updated standards and processes for accreditation of echocardiographic laboratories from The European Association of Cardiovascular Imaging: an executive summary, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol: 15, Pages: 1188-1193, ISSN: 2047-2404

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• Citations: 11

Kaier TE, Morgan D, Grapsa J, Demir OM, Paschou SA, Sundar S, Hakky S, Purkayastha S, Connolly S, Fox KF, Ahmed A, Cousins J, Nihoyannopoulos Pet al., 2014, Ventricular remodelling post-bariatric surgery: is the type of surgery relevant? A prospective study with 3D speckle tracking, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol: 15, Pages: 1256-1262, ISSN: 2047-2404

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• Citations: 28

AuthorsTask Force members, Elliott PM, Anastasakis A, Borger MA, Borggrefe M, Cecchi F, Charron P, Hagege AA, Lafont A, Limongelli G, Mahrholdt H, McKenna WJ, Mogensen J, Nihoyannopoulos P, Nistri S, Pieper PG, Pieske B, Rapezzi C, Rutten FH, Tillmanns C, Watkins Het al., 2014, 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)., Eur Heart J, Vol: 35, Pages: 2733-2779

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Windecker S, Kolh P, Alfonso F, Collet J-P, Cremer J, Falk V, Filippatos G, Hamm C, Head SJ, Jueni P, Kappetein AP, Kastrati A, Knuuti J, Landmesser U, Laufer G, Neumann F-J, Richter DJ, Schauerte P, Uva MS, Stefanini GG, Taggart DP, Torracca L, Valgimigli M, Wijns W, Witkowski A, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Pepper J, Anyanwum A, Badimon L, Bauersachs J, Baumbach A, Beygui F, Bonaros N, De Carlo M, Dobrev D, Dunning J, Eeckhout E, Gielen S, Luckraz H, Mahrholdt H, Montalescot G, Paparella D, Rastan AJ, Sanmartin M, Sergeant P, Silber S, Tamargo J, ten Berg J, Thiele H, van Geuns R-J, Wagner H-O, Wassmann S, Wendler O, Weidinger F, Ibrahimov F, Legrand V, Terzic I, Postadzhiyan A, Skoric B, Georgiou GM, Zelizko M, Junker A, Eha J, Romppanen H, Bonnet J-L, Aladashvili A, Hambrecht R, Becker D, Gudnason T, Segev A, Bugiardini R, Sakhov O, Mirrakhimov A, Pereira B, Felice H, Trovik T, Dudek D, Pereira H, Nedeljkovic MA, Hudec M, Cequier A, Erlinge D, Roffi M, Kedev S, Addad F, Yildirir A, Davies Jet al., 2014, 2014 ESC/EACTS Guidelines on myocardial revascularization, EUROPEAN HEART JOURNAL, Vol: 35, Pages: 2541-2619, ISSN: 0195-668X

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• Citations: 4070

Kidher E, Harling L, Sugden C, Ashrafian H, Casula R, Evans P, Nihoyannopoulos P, Athanasiou Tet al., 2014, Aortic stiffness is an indicator of cognitive dysfunction before and after aortic valve replacement for aortic stenosis, INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, Vol: 19, Pages: 595-604, ISSN: 1569-9293

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• Citations: 16

Kolh P, Windecker S, Alfonso F, Collet J-P, Cremer J, Falk V, Filippatos G, Hamm C, Head SJ, Jueni P, Kappetein AP, Kastrati A, Knuuti J, Landmesser U, Laufer G, Neumann F-J, Richter DJ, Schauerte P, Uva MS, Stefanini GG, Taggart DP, Torracca L, Valgimigli M, Wijns W, Witkowski A, Luis Zamorano J, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Luis Tamargo J, Tendera M, Torbicki A, Wijns W, Windecker S, Uva MS, Achenbach S, Pepper J, Anyanwu A, Badimon L, Bauersachs J, Baumbach A, Beygui F, Bonaros N, De Carlo M, Deaton C, Dobrev D, Dunning J, Eeckhout E, Gielen S, Hasdai D, Kirchhof P, Luckraz H, Mahrholdt H, Montalescot G, Paparella D, Rastan AJ, Sanmartin M, Sergeant P, Silber S, Tamargo J, ten Berg J, Thiele H, van Geuns R-J, Wagner H-O, Wassmann S, Wendler O, Luis Zamorano Jet al., 2014, 2014 ESC/EACTS Guidelines on myocardial revascularization, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 46, Pages: 517-592, ISSN: 1010-7940

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• Citations: 7

Dzaye O, Cleator S, Nihoyannopoulos P, 2014, Acute coronary artery thrombosis and vasospasm following capecitabine in conjunction with oxaliplatin treatment for cancer., BMJ Case Rep, Vol: 2014

Oral capecitabine is a prodrug of 5-fluorouracil that has been used into the management of multiple cancers because of the convenience of administration and efficacy at least comparable with 5-fluorouracil. While cardiac complications associated with the use of 5-fluorouracil are well-documented, capecitabine-induced acute coronary syndrome has rarely been reported and often attributed to coronary vasospasm. We report a patient presented with acute coronary syndrome secondary to thrombotic coronary occlusion following treatment with oral capecitabine and intravenous oxaliplatin after resection of non-metastatic, node positive colon carcinoma. Capecitabine may induce acute coronary thrombotic occlusion in addition to coronary vasospasm.

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Kristensen SD, Knuuti J, Saraste A, Anker S, Bøtker HE, Hert SD, Ford I, Gonzalez-Juanatey JR, Gorenek B, Heyndrickx GR, Hoeft A, Huber K, Iung B, Kjeldsen KP, Longrois D, Lüscher TF, Pierard L, Pocock S, Price S, Roffi M, Sirnes PA, Sousa-Uva M, Voudris V, Funck-Brentano C, AuthorsTask Force Memberset al., 2014, 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA)., Eur Heart J, Vol: 35, Pages: 2383-2431

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Nihoyannopoulos P, 2014, Why is a new journal dedicated to echocardiography required?, Echo Res Pract, Vol: 1, Pages: E1-E3, ISSN: 2055-0464

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Afilalo J, Grapsa J, Nihoyannopoulos P, Beaudoin J, Gibbs JSR, Channick RN, Langleben D, Rudski LG, Picard MH, Levine RAet al., 2014, Leaflet adaptation as a determinant of tricuspid regurgitation severity in patients with pulmonary hypertension, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 245-245, ISSN: 0195-668X

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