Imperial College London
Alternate

ProfessorPetrosNihoyannopoulos

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 3313 8156p.nihoyannopoulos

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Filippou:2020:advances/nmaa041,
author = {Filippou, CD and Tsioufis, CP and Thomopoulos, CG and Mihas, CC and Dimitriadis, KS and Sotiropoulou, LI and Chrysochoou, CA and Nihoyannopoulos, PI and Tousoulis, DM},
doi = {advances/nmaa041},
journal = {Adv Nutr},
pages = {1150--1160},
title = {Dietary Approaches to Stop Hypertension (DASH) Diet and Blood Pressure Reduction in Adults with and without Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.},
url = {http://dx.doi.org/10.1093/advances/nmaa041},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The Dietary Approaches to Stop Hypertension (DASH) diet is recognized as an effective dietary intervention to reduce blood pressure (BP). However, among randomized controlled trials (RCTs) investigating the DASH diet-mediated BP reduction, there are significant methodological and clinical differences. The purpose of this study was to comprehensively assess the DASH diet effect on BP in adults with and without hypertension, accounting for underlying methodological and clinical confounders. We systematically searched Medline and the Cochrane Collaboration Library databases and identified 30 RCTs (n = 5545 participants) that investigated the BP effects of the DASH diet compared with a control diet in hypertensive and nonhypertensive adults. Both random-effects and fixed-effect models were used to calculate the mean attained systolic BP (SBP) and diastolic BP (DBP) differences during follow-up. Subgroup and meta-regression analyses were also conducted. Compared with a control diet, the DASH diet reduced both SBP and DBP (difference in means: -3.2 mm Hg; 95% CI: -4.2, -2.3 mm Hg; P < 0.001, and -2.5 mm Hg; 95% CI: -3.5, -1.5 mm Hg; P < 0.001, respectively). Hypertension status did not modify the effect on BP reduction. The DASH diet compared with a control diet reduced SBP levels to a higher extent in trials with sodium intake >2400 mg/d than in trials with sodium intake ≤2400 mg/d, whereas both SBP and DBP were reduced more in trials with mean age <50 y than in trials of older participants. The quality of evidence was rated as moderate for both outcomes according to the Grading of Recommendations, Assessment, Development, and Evaluation approach. The adoption of the DASH diet was accompanied by significant BP reduction in adults with and without hypertension, although higher daily sodium intake and younger age enhanced the BP-lowering effect of the intervention. This meta-analysis was registered at www.crd.york.ac.uk/pro
AU  - Filippou,CD
AU  - Tsioufis,CP
AU  - Thomopoulos,CG
AU  - Mihas,CC
AU  - Dimitriadis,KS
AU  - Sotiropoulou,LI
AU  - Chrysochoou,CA
AU  - Nihoyannopoulos,PI
AU  - Tousoulis,DM
DO  - advances/nmaa041
EP  - 1160
PY  - 2020///
SP  - 1150
TI  - Dietary Approaches to Stop Hypertension (DASH) Diet and Blood Pressure Reduction in Adults with and without Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
T2  - Adv Nutr
UR  - http://dx.doi.org/10.1093/advances/nmaa041
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32330233
VL  - 11
ER  -
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