Imperial College London
Alternate

ProfessorPetrosNihoyannopoulos

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 3313 8156p.nihoyannopoulos

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Filippou:2021:10.1016/j.clnu.2021.01.030,
author = {Filippou, CD and Thomopoulos, CG and Kouremeti, MM and Sotiropoulou, LI and Nihoyannopoulos, PI and Tousoulis, DM and Tsioufis, CP},
doi = {10.1016/j.clnu.2021.01.030},
journal = {Clin Nutr},
pages = {3191--3200},
title = {Mediterranean diet and blood pressure reduction in adults with and without hypertension: A systematic review and meta-analysis of randomized controlled trials.},
url = {http://dx.doi.org/10.1016/j.clnu.2021.01.030},
volume = {40},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND & AIMS: It is unclear whether the Mediterranean diet (MedDiet) has a favorable effect on blood pressure (BP) levels because among randomized controlled trials (RCTs) investigating the MedDiet-mediated BP reduction significant methodological and clinical differences are observed. The purpose of this study was to comprehensively assess the MedDiet BP-effect compared to the usual diet or another dietary intervention (e.g. low-fat diet) in adults with and without hypertension, accounting for methodological and clinical confounders. METHODS: We systematically searched Medline and the Cochrane Collaboration Library databases and identified 35 RCTs (13,943 participants). Random-effects model was used to calculate the mean attained systolic BP (SBP) and diastolic BP (DBP) differences during follow-up. Subgroup and meta-regression analyses were also conducted. RESULTS: Compared to the usual diet and all other active intervention diets the MedDiet reduced SBP and DBP (difference in means: -1.5 mm Hg; 95% CI: -2.8, -0.1; P = 0.035, and -0.9 mm Hg; 95% CI: -1.5, -0.3; P = 0.002, respectively). Compared only to the usual diet the MedDiet reduced SBP and DBP, while compared to all other active intervention diets or only to the low-fat diet the MedDiet did not reduce SBP and DBP. The MedDiet reduced DBP levels to a higher extent in trials with mean baseline SBP ≥130 mm Hg, while both SBP and DBP were reduced more in trials with a mean follow-up period ≥16 weeks. The quality of evidence was rated as moderate for both outcomes according to the grading of recommendations, assessment, development and evaluation (GRADE) approach. CONCLUSIONS: The adoption of the MedDiet was accompanied by a relatively small, but yet significant BP reduction, while higher baseline SBP levels and longer follow-up duration enhanced the BP-lowering effect of the intervention. This meta-analysis was registered in the Inter
AU  - Filippou,CD
AU  - Thomopoulos,CG
AU  - Kouremeti,MM
AU  - Sotiropoulou,LI
AU  - Nihoyannopoulos,PI
AU  - Tousoulis,DM
AU  - Tsioufis,CP
DO  - 10.1016/j.clnu.2021.01.030
EP  - 3200
PY  - 2021///
SP  - 3191
TI  - Mediterranean diet and blood pressure reduction in adults with and without hypertension: A systematic review and meta-analysis of randomized controlled trials.
T2  - Clin Nutr
UR  - http://dx.doi.org/10.1016/j.clnu.2021.01.030
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33581952
VL  - 40
ER  -
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