We aim to understand the fundamental virus-host interactions underpinning the critical earliest stages in infection by large complex DNA viruses, focusing on herpes simplex virus as a model system. We are particularly interested in two key areas; firstly, mechanisms of early genome entry and nuclear transport; secondly the competing interactions with the host transcription machinery versus innate immune restriction mechanisms. We are currently pioneering methods combining molecular and cell biology with click-chemistry to study these processes and the single cell and single molecule levels.
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et al., 2019, Analysis of a fully infectious bio-orthogonally modified human virus reveals novel features of virus cell entry, Plos Pathogens, Vol:15, ISSN:1553-7366
et al., 2019, Human TANK-binding kinase 1 is required for early autophagy induction upon herpes simplex virus 1 infection, Journal of Allergy and Clinical Immunology, Vol:143, ISSN:0091-6749, Pages:765-769.e7
Teo CSH, O'Hare P, 2018, A bimodal switch in global protein translation coupled to eIF4H relocalisation during advancing cell-cell transmission of herpes simplex virus, Plos Pathogens, Vol:14, ISSN:1553-7366
et al., 2017, Spatiotemporal dynamics of HSV genome nuclear entry and compaction state transitions using bioorthogonal chemistry and super-resolution microscopy., Plos Pathogens, Vol:13, ISSN:1553-7366
Barbosa S, Carreira S, O'Hare P, 2017, GSK-3-mediated phosphorylation couples ER-Golgi transport and nuclear stabilization of the CREB-H transcription factor to mediate apolipoprotein secretion, Molecular Biology of the Cell, Vol:28, ISSN:1059-1524, Pages:1565-1579