Imperial College London
Alternate

ProfessorPeterO'Hare

Faculty of Medicine, Department of Infectious Disease

Chair in Virology
 
 
 
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Contact

 

+44 (0)20 7594 9517p.ohare Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Howat:2006,
author = {Howat, TJ and Barreca, C and O'Hare, P and Gog, JR and Grenfell, BT},
journal = {J R Soc Interface},
pages = {699--709},
title = {Modelling dynamics of the type I interferon response to in vitro viral infection},
url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16971338},
volume = {3},
year = {2006}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Innate immunity is crucial in the early stages of resistance to novel viral infection. The family of cytokines known as the interferons (IFNs) forms an essential component of this system: they are responsible for signalling that an infection is underway and for promoting an antiviral response in susceptible cells. We construct a spatial stochastic model, parameterized by experimental data and informed by analytic approximation, to capture the dynamics of virus-IFN interaction during in vitro infection of Madin-Darby bovine kidney cell monolayers by Herpes simplex virus 1. The dose dependence of infection progression, subsequent monolayer destruction and IFN-beta production are investigated. Implications for in vivo infections, in particular the priming of susceptible cells by IFN-beta during infection, are considered.
AU  - Howat,TJ
AU  - Barreca,C
AU  - O'Hare,P
AU  - Gog,JR
AU  - Grenfell,BT
EP  - 709
PY  - 2006///
SP  - 699
TI  - Modelling dynamics of the type I interferon response to in vitro viral infection
T2  - J R Soc Interface
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16971338
VL  - 3
ER  -
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