Publications
69 results found
Sarek G, Ma L, Enback J, et al., 2013, Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas, ONCOGENE, Vol: 32, Pages: 1091-1098, ISSN: 0950-9232
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- Citations: 12
Pekkonen P, Ojala PM, 2013, [Viral infection--a diverse causative agent of cancer]., Duodecim, Vol: 129, Pages: 1545-1551, ISSN: 0012-7183
Viral infections are a common cause for the development of cancer. Most common among the cancer-inducing viruses are human papillomaviruses, which cause cervical cancer among other things. Cancer viruses aim to keep their host cells alive and simultaneously use their oncogenes to interfere with cellular phenomena such as proliferation and programmed cell death. The most effective way of preventing viral cancers is to reduce the frequency of cancer virus infections by using vaccinations and by intervening in high-risk behavior. In addition, the infections must be detected and treated in advance of cancer development.
Buss H, Handschick K, Jurrmann N, et al., 2012, Cyclin-Dependent Kinase 6 Phosphorylates NF-κB P65 at Serine 536 and Contributes to the Regulation of Inflammatory Gene Expression, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 60
Cheng F, Pekkonen P, Ojala PM, 2012, Instigation of Notch signaling in the pathogenesis of Kaposi's sarcoma-associated herpesvirus and other human tumor viruses, FUTURE MICROBIOLOGY, Vol: 7, Pages: 1191-1205, ISSN: 1746-0913
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- Citations: 12
Paudel N, Sadagopan S, Chakraborty S, et al., 2012, Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with Multifunctional Angiogenin To Utilize Its Antiapoptotic Functions, JOURNAL OF VIROLOGY, Vol: 86, Pages: 5974-5991, ISSN: 0022-538X
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- Citations: 20
Pekkonen P, Cheng F, Sugiyama N, et al., 2012, KSHV-initiated Notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition, CANCER RESEARCH, Vol: 72, ISSN: 0008-5472
Cheng F, Pekkonen P, Laurinavicius S, et al., 2011, KSHV-Initiated Notch Activation Leads to Membrane-Type-1 Matrix Metalloproteinase-Dependent Lymphatic Endothelial-to-Mesenchymal Transition, CELL HOST & MICROBE, Vol: 10, Pages: 577-590, ISSN: 1931-3128
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- Citations: 101
Suffert G, Malterer G, Hausser J, et al., 2011, Kaposi's Sarcoma Herpesvirus microRNAs Target Caspase 3 and Regulate Apoptosis, PLOS PATHOGENS, Vol: 7, ISSN: 1553-7366
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- Citations: 92
Tvorogov D, Anisimov A, Zheng W, et al., 2010, Effective Suppression of Vascular Network Formation by Combination of Antibodies Blocking VEGFR Ligand Binding and Receptor Dimerization, CANCER CELL, Vol: 18, Pages: 630-640, ISSN: 1535-6108
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- Citations: 107
Sarek G, Jarviluoma A, Moore HM, et al., 2010, Nucleophosmin Phosphorylation by v-Cyclin-CDK6 Controls KSHV Latency, PLOS PATHOGENS, Vol: 6, ISSN: 1553-7366
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- Citations: 59
Sarek G, Ojala PM, 2010, Restoration of p53 Function by MDM2 Inhibition: Potential Strategy to Treat KSHV-Associated Malignancies, MOLECULAR BASIS FOR THERAPY OF AIDS-DEFINING CANCERS, Editors: Dittmer, Krown, Publisher: SPRINGER, Pages: 167-180, ISBN: 978-1-4419-1512-2
Cheng F, Weidner-Glunde M, Varjosalo M, et al., 2009, KSHV Reactivation from Latency Requires Pim-1 and Pim-3 Kinases to Inactivate the Latency-Associated Nuclear Antigen LANA, PLOS PATHOGENS, Vol: 5, ISSN: 1553-7366
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- Citations: 58
Lehtonen S, Linden A-M, Ojala PM, et al., 2009, [Encouraging experiences of interactive lectures]., Duodecim, Vol: 125, Pages: 2199-2205, ISSN: 0012-7183
BACKGROUND: Traditional lectures typically represent unidirectional transfer of information from teacher to students whilst interactive lectures involve student activity. MATERIAL AND METHODS: We analyzed the experiences of students and teachers of interactive lectures by observation and questionnaires during a course organized by Helsinki Biomedical Graduate School. RESULTS: Teachers and the majority of students found interactive lectures highly motivating although we observed that only a fraction of students participated in discussions. Students were of the opinion that interactivity improved their learning. CONCLUSIONS: Supplementing lectures with interactive elements encourages students to adopt active learning techniques.
Varjosalo M, Bjorklund M, Cheng F, et al., 2008, Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling, CELL, Vol: 133, Pages: 537-548, ISSN: 0092-8674
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- Citations: 146
Sarek G, Ojala PM, 2007, p53 reactivation kills KSHV lymphomas efficiently in vitro and in vivo - New hope for treating aggressive viral lymphomas, CELL CYCLE, Vol: 6, Pages: 2205-2209, ISSN: 1538-4101
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- Citations: 28
Koopal S, Furuhjelm JH, Jarviluoma A, et al., 2007, Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis, PLOS PATHOGENS, Vol: 3, Pages: 1348-1360, ISSN: 1553-7366
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- Citations: 88
Sarek G, Kurki S, Enback J, et al., 2007, Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas, JOURNAL OF CLINICAL INVESTIGATION, Vol: 117, Pages: 1019-1028, ISSN: 0021-9738
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- Citations: 113
Jarviluoma A, Ojala PA, 2006, Cell signaling pathways engaged by KSHV, BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, Vol: 1766, Pages: 140-158, ISSN: 0304-419X
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- Citations: 51
Järviluoma A, Child ES, Sarek G, et al., 2006, Phosphorylation of the cyclin-dependent kinase inhibitor p21<SUP>Cip1</SUP> on serine 130 is essential for viral cyclin-mediated bypass of a p21<SUP>Cip1</SUP>-imposed G<sub>1</sub> arrest, MOLECULAR AND CELLULAR BIOLOGY, Vol: 26, Pages: 2430-2440, ISSN: 0270-7306
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- Citations: 43
Sarek G, Järviluoma A, Ojala PM, 2006, KSHV viral cyclin inactivates p27<SUP>KIP1</SUP> through Ser10 and Tbr187 phosphorylation in proliferating primary effusion lymphomas, BLOOD, Vol: 107, Pages: 725-732, ISSN: 0006-4971
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- Citations: 49
Biberfeld P, Pyakurel P, Pak F, et al., 2006, Kaposi (KS) pathogenesis: cell origin, HHV-8 permissiveness, proliferation, genomic instability, RETROVIROLOGY, Vol: 3, ISSN: 1742-4690
Lehtonen A, Ojala PM, 2006, [Not Available]., Duodecim, Vol: 122, Pages: 1759-1766, ISSN: 0012-7183
Järviluoma A, Koopal S, Räsänen S, et al., 2004, KSHV viral cyclin binds to p27KIP1 in primary effusion lymphomas, BLOOD, Vol: 104, Pages: 3349-3354, ISSN: 0006-4971
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- Citations: 29
Kurki S, Peltonen K, Latonen L, et al., 2004, Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation, CANCER CELL, Vol: 5, Pages: 465-475, ISSN: 1535-6108
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- Citations: 338
Kaldis P, Ojala PM, Tong L, et al., 2001, CAK-independent activation of CDK6 by a viral cyclin, MOLECULAR BIOLOGY OF THE CELL, Vol: 12, Pages: 3987-3999, ISSN: 1059-1524
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- Citations: 35
Ojala PM, Yamamoto K, Castaños-Vélez E, et al., 2000, The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2, NATURE CELL BIOLOGY, Vol: 2, Pages: 819-825, ISSN: 1465-7392
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- Citations: 133
Ojala PM, Sodeik B, Ebersold MW, et al., 2000, Herpes simplex virus type 1 entry into host cells: Reconstitution of capsid binding and uncoating at the nuclear pore complex in vitro, MOLECULAR AND CELLULAR BIOLOGY, Vol: 20, Pages: 4922-4931, ISSN: 0270-7306
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- Citations: 202
Poranen MM, Daugelavicius R, Ojala PM, et al., 1999, A novel virus-host cell membrane interaction:: Membrane voltage-dependent endocytic-like entry of bacteriophage φ6 nucleocapsid, JOURNAL OF CELL BIOLOGY, Vol: 147, Pages: 671-681, ISSN: 0021-9525
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- Citations: 34
Ojala PM, Tiainen M, Salven P, et al., 1999, Kaposi's sarcoma-associated herpesvirus-encoded v-cyclin triggers apoptosis in cells with high levels of cyclin-dependent kinase 6, CANCER RESEARCH, Vol: 59, Pages: 4984-4989, ISSN: 0008-5472
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- Citations: 82
Butcher SJ, Dokland T, Ojala PM, et al., 1997, Intermediates in the assembly pathway of the double-stranded RNA virus phi 6, EMBO JOURNAL, Vol: 16, Pages: 4477-4487, ISSN: 0261-4189
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- Citations: 131
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