Imperial College London
Alternate

ProfessorPaiviOjala

Faculty of Medicine, Department of Infectious Disease

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3971p.ojala Website

 
 
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Location

 

443Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gonzalez-Molina:2019:10.3390/cells8090991,
author = {Gonzalez-Molina, J and Gramolelli, S and Liao, Z and Carlson, JW and Ojala, PM and Lehti, K},
doi = {10.3390/cells8090991},
journal = {Cells},
pages = {1--24},
title = {MMP14 in sarcoma: A regulator of tumor microenvironment communication in connective tissues},
url = {http://dx.doi.org/10.3390/cells8090991},
volume = {8},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell–cell and cell–extracellular matrix (ECM) communication. This regulation mediates processes such as ECM degradation and remodeling, cell invasion, and cancer metastasis. Thus, a comprehensive understanding of the biology of MMP14 in sarcomas will shed light on the mechanisms controlling the key processes in these diseases. Here, we provide an overview of the function and regulation of MMP14 and we discuss their relationship with clinical and pre-clinical MMP14 data in both adult and childhood sarcomas.
AU  - Gonzalez-Molina,J
AU  - Gramolelli,S
AU  - Liao,Z
AU  - Carlson,JW
AU  - Ojala,PM
AU  - Lehti,K
DO  - 10.3390/cells8090991
EP  - 24
PY  - 2019///
SN  - 2073-4409
SP  - 1
TI  - MMP14 in sarcoma: A regulator of tumor microenvironment communication in connective tissues
T2  - Cells
UR  - http://dx.doi.org/10.3390/cells8090991
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000489103800050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/2073-4409/8/9/991
UR  - http://hdl.handle.net/10044/1/75053
VL  - 8
ER  -
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