Imperial College London

ProfessorPaiviOjala

Faculty of MedicineDepartment of Infectious Disease

Chair in Viral Tumorigenesis
 
 
 
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Contact

 

+44 (0)20 7594 3971p.ojala Website

 
 
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Location

 

443Medical SchoolSt Mary's Campus

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Summary

 

Research Focus

Research on human tumor viruses has been central to development of modern cancer biology and given profound insights into cancers not only associated with infection but also cancer in general. Kaposi’s sarcoma herpesvirus (KSHV), an oncogenic gamma-2 herpesvirus, is genetically equipped to manipulate and deregulate several cellular signaling pathways. Especially AIDS-associated Kaposi’s sarcoma (KS) is strongly linked to immunosuppression and remains a significant health problem worldwide due to persisting HIV epidemic in Africa, and an increase in cases of recurrence even in the HAART-treated AIDS patients. KS is an angiogenic, histologically complex tumor, which consists of multifocal lesions of proliferating, latently KSHV-infected cells that are characterized by spindle-like morphology, and express markers of multiple cell types such as endothelial, smooth muscle cells, fibroblasts etc. KSHV is suggested to originate from endothelial cells (ECs) and it infects various types of ECs in culture; numerous studies describing consequences of KSHV infection of primary or immortalized vascular and lymphatic ECs support them as a valuable model to understand KSHV biology and pathogenesis.

 

For more information please visit my group's page at http://www1.imperial.ac.uk/departmentofmedicine/divisions/infectiousdiseases/viro/virushost/

Collaborators

Prof Niklas Feldhahn, Imperial College London, Hammersmith Hospital, Kaposi sarcoma herpesvirus pathobiology, 2017

Professor Mark Bower, Chelsea and Westminster Hospital, Kaposi's sarcoma, 2016

Guest Lectures

Invited talk, The Pirbright Institute, Surrey, UK, 2018

BioCity Symposium on Checkpoints & Quality Control, University of Turku, Finland, Biocity Turku, 2017

Invited talk, University of Erlangen, Erlangen, Germany, 2017

Invited talk, University of Cambridge, Cambridge, UK, 2016

Invited talk, Finnish Cancer Institute, Jyväskylä, Finland, 2016

Viruses and human cancer, Keystone Symposium, Big Sky, Montana, USA, 2015

Advanced seminars in cancer biology, including infection-associated tumor, Karolinska Institutet, Stockholm, Sweden, 2012

Cancer and Control of Genomic Integrity (CANGENIN), Imperial College London, London, UK, 2011

3nd Genome Instability Workshop, (IFOM-IEO) FIRC Institute of Molecular Oncology Foundation (IFOM) and the Department of Experimental Oncology of the European Institute of Oncology (IEO), Milan, Italy, 2010

Advances in Infection and Cancer, The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg, Germany, 2010

EMBO Workshop: Lymphatic & Blood Vasculature - From Models to Human Disease, Biomedicum Helsinki, Univ of Helsinki, Helsinki, Finland, 2009

Invited talk, CRUK Institute for Cancer Studies , University of Birmingham, Birmingham, UK, 2009

2nd Genome Instability Workshop, A joint Workshop of the GENICA FP7 Health Programme and the CANGENIN COST Network, Athens, Greece, 2009

Nobel Prize 2008 Meeting: Viruses and Cancer, Danish Biotechnological Society & Danish Society for Biochemistry and Molecular Biology, Copenhagen, Denmark, 2009