Imperial College London

Peter Openshaw - Professor of Experimental Medicine

Faculty of MedicineNational Heart & Lung Institute

Senior Consul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

326 results found

Goritzka M, Makris S, Kausar F, Durant L, Pereira C, Kumagai Y, Culley F, Mack M, Openshaw P, Akira S, Johansson Cet al., 2014, Alveolar macrophages modulate innate immune responses to Respiratory Syncytial Virus (RSV) infection through MAVS signalling and type I interferons, 9th European-Mucosal-Immunology-Group Meeting, Publisher: WILEY-BLACKWELL, Pages: 7-8, ISSN: 0019-2805

Conference paper

Openshaw P, 2014, Protective and inflammatory responses in respiratory virus infections, 9th European-Mucosal-Immunology-Group Meeting, Publisher: WILEY-BLACKWELL, Pages: 8-8, ISSN: 0019-2805

Conference paper

Lambert L, Sagfors AM, Openshaw PJM, Culley FJet al., 2014, Immunity to RSV in early-life, FRONTIERS IN IMMUNOLOGY, Vol: 5, ISSN: 1664-3224

Journal article

Nguyen-Van-Tam JS, Openshaw PJM, Nicholson KG, 2014, Antivirals for influenza: where now for clinical practice and pandemic preparedness?, LANCET, Vol: 384, Pages: 386-387, ISSN: 0140-6736

Journal article

Schiavoni I, Fedele G, Quattrini A, Bianco M, Schnoeller C, Openshaw PJ, Locht C, Ausiello CMet al., 2014, Live Attenuated B. pertussis BPZE1 Rescues the Immune Functions of Respiratory Syncytial Virus Infected Human Dendritic Cells by Promoting Th1/Th17 Responses, PLOS ONE, Vol: 9, ISSN: 1932-6203

Journal article

Goritzka M, Durant LR, Pereira C, Salek-Ardakani S, Openshaw PJM, Johansson Cet al., 2014, Alpha/Beta Interferon Receptor Signaling Amplifies Early Proinflammatory Cytokine Production in the Lung during Respiratory Syncytial Virus Infection, JOURNAL OF VIROLOGY, Vol: 88, Pages: 6128-6136, ISSN: 0022-538X

Journal article

Goritzka M, Durant LR, Pereira C, Salek-Ardakani S, Openshaw P, Johansson Cet al., 2014, Interferon-a/b receptor signalling is amplifying early proinflammatory cytokine production in the lung during Respiratory Syncytial Virus (RSV) infection, Annual Congress of the British-Society-for-Immunology, Publisher: Wiley, Pages: 6128-6136, ISSN: 0019-2805

Type I interferons (IFNs) are produced early upon virus infection and signal through the alpha/beta interferon (IFN-/) receptor(IFNAR) to induce genes that encode proteins important for limiting viral replication and directing immune responses. Toinvestigate the extent to which type I IFNs play a role in the local regulation of inflammation in the airways, we examined theirimportance in early lung responses to infection with respiratory syncytial virus (RSV). IFNAR1-deficient (IFNAR1 / ) mice displayedincreased lung viral load and weight loss during RSV infection. As expected, expression of IFN-inducible genes was markedlyreduced in the lungs of IFNAR1 / mice. Surprisingly, we found that the levels of proinflammatory cytokines and chemokinesin the lungs of RSV-infected mice were also greatly reduced in the absence of IFNAR signaling. Furthermore, low levels ofproinflammatory cytokines were also detected in the lungs of IFNAR1 / mice challenged with noninfectious innate immunestimuli such as selected Toll-like receptor (TLR) agonists. Finally, recombinant IFN- was sufficient to potentiate the productionof inflammatory mediators in the lungs of wild-type mice challenged with innate immune stimuli. Thus, in addition to itswell-known role in antiviral resistance, type I IFN receptor signaling acts as a central driver of early proinflammatory responsesin the lung. Inhibiting the effects of type I IFNs may therefore be useful in dampening inflammation in lung diseases characterizedby enhanced inflammatory cytokine production.

Conference paper

Guvenel AK, Chiu C, Openshaw PJM, 2014, Current concepts and progress in RSV vaccine development, EXPERT REVIEW OF VACCINES, Vol: 13, Pages: 333-344, ISSN: 1476-0584

Journal article

Schnoeller C, Roux X, Sawant D, Raze D, Olszewska W, Locht C, Openshaw PJet al., 2014, Attenuated Bordetella pertussis Vaccine Protects against Respiratory Syncytial Virus Disease via an IL-17-Dependent Mechanism, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, Pages: 194-202, ISSN: 1073-449X

Journal article

Harker JA, Yamaguchi Y, Culley FJ, Tregoning JS, Openshaw PJMet al., 2014, Delayed sequelae of neonatal RSV infection are dependent on cells of the innate immune system, Journal of Virology, ISSN: 0022-538X

Infection with respiratory syncytial virus (RSV) in neonatal mice leads to exacerbated disease if mice are re-infected with the same virus as adults. Both T cells and host MHC genotype contribute to this phenomenon, but the part played by innate immunity has not been defined. Since macrophages and natural killer (NK) cells play key roles in regulating inflammation during RSV infection of adult mice, we studied the role of these cells in exacerbated inflammation following neonatal RSV sensitization/adult re-infection. Compared to those undergoing primary adult infection, neonatally sensitized mice showed enhanced airway fluid levels of interleukin-6 (IL-6), interferon alpha (IFNα), CXCL1 (KC) and tumor necrosis factor alpha (TNFα) at 12-24h, and IL-4, IL-5, IFNγ and CCL11 (eotaxin) at day 4 after re-infection. Weight loss during re-infection was accompanied by an initial influx of NK cells and granulocytes into the airways and lungs, followed by T cells. NK depletion during re-infection attenuated weight loss, but did not alter T cell responses. Depleting alveolar macrophages with inhaled clodronate liposomes reduced both NK and T cell numbers and attenuated weight loss. These findings indicate a hitherto unappreciated role for the innate immune response in governing the pathogenic recall responses to RSV infection.

Journal article

Dunning JW, Merson L, Rohde GGU, Gao Z, Semple MG, Tran D, Gordon A, Olliaro PL, Khoo SH, Bruzzone R, Horby P, Cobb JP, Longuere K, Kellam P, Nichol A, Brett S, Everett D, Walsh TS, Hien T, Yu H, Zambon M, Ruiz-Palacios G, Lang T, Akhvlediani T, Hayden FG, Marshall J, Webb S, Angus DC, Shindo N, van der Werf S, Openshaw PJM, Farrar J, Carson G, Baillie JKet al., 2014, Open source clinical science for emerging infections, The Lancet Infectious Diseases, Vol: 14, Pages: 8-9, ISSN: 1473-3099

Journal article

Guvenel A, Jozwik A, Paras A, Chiu C, Openshaw Pet al., 2013, CD4 Virus + T cell subsets in experimental human infection with respiratory syncytial, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 123-124, ISSN: 0019-2805

Conference paper

Tregoning JS, Wang B, McDonald JU, Yamaguchi Y, Harker JA, Goritzka M, Johansson C, Bukreyev A, Collins PL, Openshaw PJet al., 2013, Respiratory syncytial virus (RSV) infection during early life suppresses antibody responses by the induction of interferon gamma, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 104-104, ISSN: 0019-2805

Conference paper

Guvenal A, Jozwik A, Paras A, Openshaw P, Chiu Cet al., 2013, CD4+ T cell subsets in experimental human infection with Respiratory Syncytial Virus, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 123-123, ISSN: 0019-2805

Conference paper

Farhadi N, Lambert L, Triulzi C, Openshaw PJM, Guerra N, Culley FJet al., 2013, Natural Killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation, Journal of Allergy and Clinical Immunology

BackgroundThe diverse roles of innate immune cells in the pathogenesis of asthma remain to be fully defined. Natural killer (NK) cells are innate lymphocytes which can regulate adaptive immune responses. NK cells are activated in asthma; however, their role in allergic airway inflammation is not fully understood.ObjectiveWe investigated the importance of NK cells in house dust mite (HDM) triggered allergic pulmonary inflammation. Specifically, we aimed to determine the role of the major NK cell activating receptor NKG2D and NK cell effector functions mediated by granzyme B.MethodsAllergic airway inflammation was induced in the airways of mice by repeated intranasal HDM extract administration and responses in wild type and NKG2D deficient mice were compared. Adoptive transfer studies were used to identify the cells and mechanisms involved.ResultsMice lacking NKG2D were resistant to the induction of allergic inflammation and showed little pulmonary eosinophilia, few airway Th2 cells and no rise in serum IgE after multiple HDM allergen exposures. However, NKG2D was not required for pulmonary inflammation after a single inoculation of allergen. NKG2D deficient mice showed no alteration in responses to respiratory virus infection. Transfer of wild type NK cells (but not CD3+ cells) into NKG2D deficient mice restored allergic inflammatory responses only if the NK cells expressed granzyme B. ConclusionThese studies establish a pivotal role for NK cell NKG2D and granzyme B in the pathogenesis of HDM induced allergic lung disease, and identify novel therapeutic targets for the prevention and treatment of asthma.

Journal article

Openshaw PJM, 2013, A Gene Expression Signature for RSV: Clinical Implications and Limitations, PLOS MEDICINE, Vol: 10, ISSN: 1549-1277

Journal article

Durant LR, Makris S, Voorburg CM, Loebbermann J, Johansson C, Openshaw PJMet al., 2013, Regulatory T Cells Prevent Th2 Immune Responses and Pulmonary Eosinophilia during Respiratory Syncytial Virus Infection in Mice, JOURNAL OF VIROLOGY, Vol: 87, Pages: 10946-10954, ISSN: 0022-538X

Journal article

Semple MG, Myles PR, Nicholson KG, Lim WS, Read RC, Taylor BL, Brett SJ, Openshaw PJM, Enstone JE, McMenamin J, Bannister B, Nguyen-Van-Tam JSet al., 2013, An Evaluation of Community Assessment Tools (CATs) in Predicting Use of Clinical Interventions and Severe Outcomes during the A(H1N1)pdm09 Pandemic, PLOS ONE, Vol: 8, ISSN: 1932-6203

Journal article

Openshaw PJ, Chiu C, 2013, Protective and dysregulated T cell immunity in RSV infection, CURRENT OPINION IN VIROLOGY, Vol: 3, Pages: 468-474, ISSN: 1879-6257

Journal article

Dodd JS, Clark D, Muir R, Korpis C, Openshaw PJMet al., 2013, Endogenous IL-21 regulates pathogenic mucosal CD4 T-cell responses during enhanced RSV disease in mice, MUCOSAL IMMUNOLOGY, Vol: 6, Pages: 704-717, ISSN: 1933-0219

Journal article

Tregoning JS, Wang BL, McDonald JU, Yamaguchi Y, Harker JA, Goritzka M, Johansson C, Bukreyev A, Collins PL, Openshaw PJet al., 2013, Neonatal antibody responses are attenuated by interferon-gamma produced by NK and T cells during RSV infection, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 5576-5581, ISSN: 0027-8424

Journal article

Myles P, Nguyen-Van-Tam JS, Semple MG, Brett SJ, Bannister B, Read RC, Taylor BL, McMenamin J, Enstone JE, Nicholson KG, Openshaw PJ, Lim WSet al., 2013, Differences between asthmatics and nonasthmatics hospitalised with influenza A infection, EUROPEAN RESPIRATORY JOURNAL, Vol: 41, Pages: 824-831, ISSN: 0903-1936

Journal article

Openshaw P, 2013, Dr Brigitte Askonas (1923-2012), EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 43, Pages: 865-866, ISSN: 0014-2980

Journal article

Hansel TT, Johnston SL, Openshaw PJ, 2013, Microbes and mucosal immune responses in asthma, LANCET, Vol: 381, Pages: 861-873, ISSN: 0140-6736

Journal article

Loebbermann J, Durant L, Thornton H, Johansson C, Openshaw PJet al., 2013, Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 2987-2992, ISSN: 0027-8424

Journal article

Openshaw PJ, 2013, The Mouse Model of Respiratory Syncytial Virus Disease, CHALLENGES AND OPPORTUNITIES FOR RESPIRATORY SYNCYTIAL VIRUS VACCINES, Vol: 372, Pages: 359-369, ISSN: 0070-217X

Journal article

Farhadi N, Guerra N, Openshaw PJ, Culley FJet al., 2013, The Role Of Nk Cells In Allergic Inflammation Of The Lung, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X

Journal article

Pollard AJ, Savulescu J, Oxford J, Hill AVS, Levine MM, Lewis DJM, Read RC, Graham DY, Sun W, Openshaw P, Gordon SBet al., 2012, Human microbial challenge: the ultimate animal model, LANCET INFECTIOUS DISEASES, Vol: 12, Pages: 903-905, ISSN: 1473-3099

Journal article

Habibi MS, Openshaw PJM, 2012, Benefit and harm from immunity to respiratory syncytial virus: implications for treatment, CURRENT OPINION IN INFECTIOUS DISEASES, Vol: 25, Pages: 687-694, ISSN: 0951-7375

Journal article

Sridhar S, Begom S, Bermingham A, Ziegler T, Roberts KL, Barclay WS, Openshaw P, Lalvani Aet al., 2012, Predominance of heterosubtypic IFN-?-only-secreting effector memory T cells in pandemic H1N1 naive adults, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 42, Pages: 2913-2924, ISSN: 0014-2980

Journal article

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