Imperial College London

Peter Openshaw - Professor of Experimental Medicine

Faculty of MedicineNational Heart & Lung Institute

Senior Consul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

326 results found

Yamaguchi Y, Harker JA, Wang B, Openshaw PJ, Tregoning JS, Culley FJet al., 2012, Preexposure to CpG Protects against the Delayed Effects of Neonatal Respiratory Syncytial Virus Infection, JOURNAL OF VIROLOGY, Vol: 86, Pages: 10456-10461, ISSN: 0022-538X

Journal article

Dolan GP, Myles PR, Brett SJ, Enstone JE, Read RC, Openshaw PJM, Semple MG, Lim WS, Taylor BL, McMenamin J, Nicholson KG, Bannister B, Nguyen-Van-Tam JSet al., 2012, The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection, PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Myles PR, Semple MG, Lim WS, Openshaw PJM, Gadd EM, Read RC, Taylor BL, Brett SJ, McMenamin J, Enstone JE, Armstrong C, Bannister B, Nicholson KG, Nguyen-Van-Tam JSet al., 2012, Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK, THORAX, Vol: 67, Pages: 709-717, ISSN: 0040-6376

Journal article

Edwards MR, Bartlett NW, Hussell T, Openshaw P, Johnston SLet al., 2012, The microbiology of asthma, NATURE REVIEWS MICROBIOLOGY, Vol: 10, Pages: 459-471, ISSN: 1740-1526

Journal article

Everitt A, Clare S, Pertel T, John S, Wash R, Smith S, Chin C, Feeley E, Simms J, Adams D, Wise H, Kane L, Goulding D, Digard P, Anttila V, Baillie K, Walsh T, Hume D, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon S, Smyth RS, Openshaw P, Dougan G, Brass A, Kellam Pet al., 2012, IFITM3 restricts the morbidity and mortality associated with influenza, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, Vol: 16, Pages: E79-E79, ISSN: 1201-9712

Journal article

Durant L, Schnoeller C, Loebbermann J, Johansson C, Thornton H, Sweeney NP, Schuijs M, O'Garra A, Openshaw PJMet al., 2012, Roles for IL-10 in respiratory syncytial virus infection, 1st Biennial Symposium on Regulatory T Cells and T Helper Cells, Publisher: WILEY-BLACKWELL, Pages: 4-4, ISSN: 0019-2805

Conference paper

Dunning J, Openshaw P, 2012, Severe Influenza: Clinical Features and Treatment Options (accepted for publication 04 April 2012), Current Respiratory Medicine Reviews, Vol: 8, Pages: 208-227

Journal article

Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, GenISIS Investigators, MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam Pet al., 2012, IFITM3 restricts the morbidity and mortality associated with influenza., Nature, Vol: 484, Pages: 519-523

The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus can spread and the ability of a generally mild infection to induce severe morbidity and mortality in a subset of the population. Recent in vitro studies show that the interferon-inducible transmembrane (IFITM) protein family members potently restrict the replication of multiple pathogenic viruses1, 2, 3, 4, 5, 6, 7. Both the magnitude and breadth of the IFITM proteins’ in vitro effects suggest that they are critical for intrinsic resistance to such viruses, including influenza viruses. Using a knockout mouse model8, we now test this hypothesis directly and find that IFITM3 is essential for defending the host against influenza A virus in vivo. Mice lacking Ifitm3 display fulminant viral pneumonia when challenged with a normally low-pathogenicity influenza virus, mirroring the destruction inflicted by the highly pathogenic 1918 ‘Spanish’ influenza9, 10. Similar increased viral replication is seen in vitro, with protection rescued by the re-introduction of Ifitm3. To test the role of IFITM3 in human influenza virus infection, we assessed the IFITM3 alleles of individuals hospitalized with seasonal or pandemic influenza H1N1/09 viruses. We find that a statistically significant number of hospitalized subjects show enrichment for a minor IFITM3 allele (SNP rs12252-C) that alters a splice acceptor site, and functional assays show the minor CC genotype IFITM3 has reduced influenza virus restriction in vitro. Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans.

Journal article

Myles PR, Nguyen-Van-Tam JS, Lim WS, Nicholson KG, Brett SJ, Enstone JE, McMenamin J, Openshaw PJM, Read RC, Taylor BL, Bannister B, Semple MGet al., 2012, Comparison of CATs, CURB-65 and PMEWS as Triage Tools in Pandemic Influenza Admissions to UK Hospitals: Case Control Analysis Using Retrospective Data, PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Loebbermann J, Thornton H, Durant L, Sparwasser T, Webster KE, Sprent J, Culley FJ, Johansson C, Openshaw PJet al., 2012, Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection, MUCOSAL IMMUNOLOGY, Vol: 5, Pages: 161-172, ISSN: 1933-0219

Journal article

Loebbermann J, Schnoeller C, Thornton H, Durant L, Sweeney NP, Schuijs M, O'Garra A, Johansson C, Openshaw PJet al., 2012, IL-10 Regulates Viral Lung Immunopathology during Acute Respiratory Syncytial Virus Infection in Mice, PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Wythe SE, Dodd JS, Openshaw PJ, Schwarze Jet al., 2012, OX40 Ligand and Programmed Cell Death 1 Ligand 2 Expression on Inflammatory Dendritic Cells Regulates CD4 T Cell Cytokine Production in the Lung during Viral Disease, JOURNAL OF IMMUNOLOGY, Vol: 188, Pages: 1647-1655, ISSN: 0022-1767

Journal article

Sridhar S, Begom S, Bermingham A, Ziegler T, Roberts KL, Barclay WS, Openshaw P, Lalvani Aet al., 2012, Predominance of heterosubtypic IFN-gamma-only-secreting effector memory T cells in pandemic H1N1 naive adults, Pages: 2913-2924, ISSN: 1521-4141

The 2009/10 pandemic (pH1N1) highlighted the need for vaccines conferring heterosubtypic immunity against antigenically shifted influenza strains. Although cross-reactive T cells are strong candidates for mediating heterosubtypic immunity, little is known about the population-level prevalence, frequency, and cytokine-secretion profile of heterosubtypic T cells to pH1N1. To assess this, pH1N1 sero-negative adults were recruited. Single-cell IFN-gamma and IL-2 cytokine-secretion profiles to internal proteins of pH1N1 or live virus were enumerated and characterised. Heterosubtypic T cells recognising pH1N1 core proteins were widely prevalent, being detected in 90% (30 of 33) of pH1N1-naive individuals. Although the last exposure to influenza was greater than 6 months ago, the frequency and proportion of the IFN-gamma-only-secreting T-cell subset was significantly higher than the IL-2-only-secreting subset. CD8(+) IFN-gamma-only-secreting heterosubtypic T cells were predominantly CCR7(-) CD45RA(-) effector-memory phenotype, expressing the tissue-homing receptor CXCR3 and degranulation marker CD107. Receipt of the 2008-09 influenza vaccine did not alter the frequency of these heterosubtypic T cells, highlighting the inability of current vaccines to maintain this heterosubtypic T-cell pool. The surprisingly high prevalence of pre-existing circulating pH1N1-specific CD8(+) IFN-gamma-only-secreting effector memory T cells with cytotoxic and lung-homing potential in pH1N1-seronegative adults may partly explain the low case fatality rate despite high rates of infection of the pandemic in young adults.

Conference paper

Loebbermann J, Thornton H, Sparwasser T, Webster K, Sprent J, Culley F, Johansson C, Openshaw Pet al., 2011, Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 181-181, ISSN: 0019-2805

Conference paper

Dodd J, Muir R, Affendi S, Nickson E, Openshaw Pet al., 2011, Lung NKT cells modulate NK and T cell activity to drive Th2 responses during respiratory viral infection, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 98-98, ISSN: 0019-2805

Conference paper

Dodd J, Clark D, Muir R, Korpis C, Openshaw Pet al., 2011, Endogenous IL-21 regulates pathogenic CD4 T cell responses during respiratory viral infection, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 164-164, ISSN: 0019-2805

Conference paper

Dodd J, Nickson E, Openshaw P, 2011, IL-7 drives an early Th17 environment upon respiratory viral challenge, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 123-123, ISSN: 0019-2805

Conference paper

Schuijs M, Hartmann S, Openshaw P, Schnoeller Cet al., 2011, Helminth-derived immunomodulator AvCystatin blocks Th2 driven lung eosinophillia in mice infected with respiratory syncytial virus, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 185-185, ISSN: 0019-2805

Conference paper

Habibi MS, Durant L, Paras A, Thornton H, Openshaw PJMet al., 2011, Human protective and regulatory T cell responses during experimental respiratory syncytial virus infection, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 199-199, ISSN: 0019-2805

Conference paper

Schnoeller C, Loebbermann J, Durant L, Johansson C, Thornton H, O'Garra A, Openshaw Pet al., 2011, Roles for IL-10 in RSV infection, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 199-199, ISSN: 0019-2805

Conference paper

Lim WS, Bewick T, Myles P, Greenwood S, Nguyen-Van-Tam JS, Brett S, Semple MG, Openshaw PJ, Bannister B, Read RC, Taylor B, McMenamin J, Enstone JE, Nicholson KGet al., 2011, The increasing importance of innate antimicrobials response, THORAX, Vol: 66, Pages: 1091-1091, ISSN: 0040-6376

Journal article

Dunning J, Nguyen-Van-Tam J, Nicholson K, Openshaw Pet al., 2011, Doctors accepting flu vaccination is the sensible and responsible choice, BMJ: British Medical Journal

Journal article

Wack A, Openshaw P, O'Garra A, 2011, Contribution of cytokines to pathology and protection in virus infection, CURRENT OPINION IN VIROLOGY, Vol: 1, Pages: 184-195, ISSN: 1879-6257

Journal article

Olszewska W, Ispas G, Schnoeller C, Sawant D, Van de Casteele T, Nauwelaers D, Van Kerckhove B, Roymans D, De Meulder M, Rouan MC, Van Remoortere P, Bonfanti JF, Van Velsen F, Koul A, Vanstockem M, Andries K, Sowinski P, Wang B, Openshaw P, Verloes Ret al., 2011, Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model, EUROPEAN RESPIRATORY JOURNAL, Vol: 38, Pages: 401-408, ISSN: 0903-1936

Journal article

Brett SJ, Myles P, Lim WS, Enstone JE, Bannister B, Semple MG, Read RC, Taylor BL, McMenamin J, Nicholson KG, Nguyen-Van-Tam JS, Openshaw PJMet al., 2011, Pre-Admission Statin Use and In-Hospital Severity of 2009 Pandemic Influenza A(H1N1) Disease, PLOS ONE, Vol: 6, ISSN: 1932-6203

Journal article

Enstone JE, Myles PR, Openshaw PJM, Gadd EM, Lim WS, Semple MG, Read RC, Taylor BL, McMenamin J, Armstrong C, Bannister B, Nicholson KG, Nguyen-Van-Tam JSet al., 2011, Nosocomial Pandemic (H1N1) 2009, United Kingdom, 2009-2010, EMERGING INFECTIOUS DISEASES, Vol: 17, Pages: 592-598, ISSN: 1080-6040

Journal article

Loebbermann J, Thornton H, Sparwasser T, Johansson C, Openshaw Pet al., 2011, Regulation of immunity during viral lung infection, JOURNAL OF IMMUNOLOGY, Vol: 186, ISSN: 0022-1767

Journal article

Bewick T, Myles P, Greenwood S, Nguyen-Van-Tam JS, Brett SJ, Semple MG, Openshaw PJ, Bannister B, Read RC, Taylor BL, McMenamin J, Enstone JE, Nicholson KG, Lim WSet al., 2011, Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults, THORAX, Vol: 66, Pages: 247-252, ISSN: 0040-6376

Journal article

Habibi MS, Patel S, Openshaw P, 2011, Hot topics in the prevention of respiratory syncytial virus disease., Expert Rev Vaccines, Vol: 10, Pages: 291-293

The 7th International Respiratory Syncytial Virus Symposium took place in Hotel Blijdorp, Rotterdam, The Netherlands. The series has been running since 1996; this meeting took place after a 3-year gap, and was attended by approximately 200 clinicians, scientists and industry representatives from all over the world. The conference covered all aspects of respiratory syncytial virus disease, including virology, cell biology, pathogenesis, clinical presentation, diagnosis, immunology, vaccines, antivirals and other therapeutic approaches. Reviews by invited keynote speakers were accompanied by oral and poster presentations, with ample opportunity for discussion of unpublished work. This article summarizes a small selection of hot topics from the meeting, focused on pathogenesis, therapeutics and vaccine development.

Journal article

Telcian AG, Laza-Stanca V, Edwards MR, Harker JA, Wang H, Bartlett NW, Mallia P, Zdrenghea MT, Kebadze T, Coyle AJ, Openshaw PJM, Stanciu LA, Johnston SLet al., 2011, RSV-Induced Bronchial Epithelial Cell PD-L1 Expression Inhibits CD8(+) T Cell Nonspecific Antiviral Activity, JOURNAL OF INFECTIOUS DISEASES, Vol: 203, Pages: 85-94, ISSN: 0022-1899

Journal article

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