Imperial College London

Peter Openshaw - Professor of Experimental Medicine

Faculty of MedicineNational Heart & Lung Institute

Senior Consul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

326 results found

Openshaw PJM, 2008, Susan Elizabeth Openshaw (nee Scott Stokes) - Obituary, BRITISH MEDICAL JOURNAL, Vol: 336, Pages: 621-621, ISSN: 0959-8146

Journal article

Helson R, Olszewska W, Singh M, Megede JZ, Melero JA, Hagan DO, Openshaw PJMet al., 2008, Polylactide-co-glycolide (PLG) microparticles modify the immune response to DNA vaccination, VACCINE, Vol: 26, Pages: 753-761, ISSN: 0264-410X

Journal article

Harker J, Bukreyev A, Collins PL, Wang B, Openshaw PJM, Tregoning JSet al., 2007, Virally delivered Cytokines alter the immune response to future lung infections, JOURNAL OF VIROLOGY, Vol: 81, Pages: 13105-13111, ISSN: 0022-538X

Journal article

Samarasinghe SR, Nawroly N, Karlsson H, Openshaw P, Vitteta E, Veys P, Amrolia Pet al., 2007, Functional characterisaition of alloreactive T-Cells identifies CD25 and CD71 as the optimal targets for allodepletion strategies, 49th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 649A-649A, ISSN: 0006-4971

Conference paper

Dodd JS, Clark D, O'Brien D, Korpis C, Openshaw PJMet al., 2007, IL-21 depletion exacerbates augmented respiratory syncytial virus (RSV) disease by deregulating control of dendritic cell: CD4 T cell stimulation, Annual Congress of the British-Society-of-Immunology, Publisher: BLACKWELL PUBLISHING, Pages: 14-14, ISSN: 0019-2805

Conference paper

Wythe SE, Dodd JS, Openshaw PJ, Schwarze Jet al., 2007, Differential expression of CD40, OX40L & PDL2 on lung dendritic cells in polarised immune responses to Respiratory Syncytial Virus (RSV), Annual Congress of the British-Society-of-Immunology, Publisher: BLACKWELL PUBLISHING, Pages: 15-15, ISSN: 0019-2805

Conference paper

Samarasinghe S, Karlsson H, Nawroly N, Openshaw P, Veys P, Amrolia Pet al., 2007, Enhanced depletion of alloreactive T cells using combined CD25/71 immunomagnetic selection, Tandem BMT Meeting 2007, Publisher: ELSEVIER SCIENCE INC, Pages: 21-21, ISSN: 1083-8791

Conference paper

Moghaddam A, Olszewska W, Wang B, Tregoning JS, Helson R, Sattentau QJ, Openshaw PJMet al., 2006, A potential molecular mechanism for hypersensitivity caused by formalin- inactivated vaccines, NATURE MEDICINE, Vol: 12, Pages: 905-907, ISSN: 1078-8956

Journal article

Culley FJ, Pennycook AAJ, Tregoning JS, Dodd JS, Walzl G, Wells TN, Hussell T, Openshaw PJMet al., 2006, Role of CCL5 (RANTES) in viral lung disease, JOURNAL OF VIROLOGY, Vol: 80, Pages: 8151-8157, ISSN: 0022-538X

Journal article

Smyth RL, Openshaw PJM, 2006, Bronchiolitis, LANCET, Vol: 368, Pages: 312-322, ISSN: 0140-6736

Journal article

Openshaw P, 2006, T cells take the inside track, NATURE MEDICINE, Vol: 12, Pages: 614-615, ISSN: 1078-8956

Journal article

Culley FJ, Pennycook AMJ, Tregoning JS, Hussell T, Openshaw PJMet al., 2006, Differential chemokine expression following respiratory virus infection reflects Th1-or Th2-based immunopathology, Journal of Virology, Vol: 80, Pages: 4521-4527, ISSN: 1098-5514

Journal article

Wilkinson TM, Donaldson GC, Johnston SL, Openshaw PJ, Wedzicha JAet al., 2006, Respiratory syncytial virus, airway inflammation, and FEV1 decline in patients with chronic obstructive pulmonary disease, American Journal of Respiratory and Critical Care Medicine, Vol: 173, Pages: 871-876, ISSN: 1073-449X

Journal article

Dodd JS, Korpis C, Openshaw PJM, 2005, IL-21 reduces immunopathology in respiratory viral disease in a T cell-dependent manner, IMMUNOLOGY, Vol: 116, Pages: 84-84, ISSN: 0019-2805

Journal article

Tourdot S, Hussell T, Openshaw PJM, Edwards L, Lloyd CMet al., 2005, RSV infection provokes airway remodelling in non-sensitised allergen challenged mice, IMMUNOLOGY, Vol: 116, Pages: 53-53, ISSN: 0019-2805

Journal article

Harker J, Tregoning JS, Bukreyev A, Yamaguchi Y, Mihm D, Collins P, Openshaw PJMet al., 2005, Contrasting effects of virally expressed IFN-gamma and IL-4 in neonatal and adult mice, IMMUNOLOGY, Vol: 116, Pages: 25-25, ISSN: 0019-2805

Journal article

Godkin A, Openshaw P, Thomas HC, 2005, Immune tolerance to hepatitis C virus acquired during engraftment of bone marrow transplant, JOURNAL OF VIRAL HEPATITIS, Vol: 12, Pages: 604-608, ISSN: 1352-0504

Journal article

Beyer M, Wang HW, Peters N, Doths S, Koerner-Rettberg C, Openshaw PJ, Schwarze Jet al., 2005, The beta2 integrin CDIIc distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo, RESPIRATORY RESEARCH, Vol: 6, ISSN: 1465-9921

Journal article

Openshaw PJM, Tregoning JS, 2005, Immune responses and disease enhancement during respiratory syncytial virus infection, CLINICAL MICROBIOLOGY REVIEWS, Vol: 18, Pages: 541-+, ISSN: 0893-8512

Journal article

, 2005, Methods of modifying an antigen to modify the Th2-type bias of the Th1/Th2-type immune response of an animalInternational (PCT) patent with Publication Number (, UK patent 0326439 (7WO2005/049074)

Patent

Matthews SP, Tregoning JS, Coyle AJ, Hussell T, Openshaw PJMet al., 2005, Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection, JOURNAL OF VIROLOGY, Vol: 79, Pages: 2050-2057, ISSN: 0022-538X

Journal article

Openshaw PJM, Tregoning J, Harker J, 2005, RSV 2005: Global impact, changing concepts, and new challenges., Viral Immunol, Vol: 18, Pages: 749-751, ISSN: 0882-8245

Journal article

Openshaw PJM, 2005, Antiviral immune responses and lung inflammation after respiratory syncytial virus infection., Proc Am Thorac Soc, Vol: 2, Pages: 121-125, ISSN: 1546-3222

Respiratory syncytial virus (RSV) is one of the commonest and most troublesome viruses of infancy. It causes most cases of bronchiolitis, which is associated with wheezing in later childhood. In primary infection, the peak of disease coincides not with the peak of viral replication but with the development of specific T and B cell responses. This immune response is apparently responsible for much of the disease. Animal models clearly show that a range of immune responses can enhance disease severity, particularly after vaccination with formalin-inactivated RSV. Prior immune sensitization leads to exuberant chemokine production, an excessive cellular influx, and an overabundance of cytokines during RSV challenge. The inflammatory host response to viral infection may be relevant not only to childhood bronchiolitis, but also to obstructive lung diseases in adults.

Journal article

Openshaw PJM, Yamaguchi Y, Tregoning JS, 2004, Childhood infections, the developing immune system, and the origins of asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 114, Pages: 1275-1277, ISSN: 0091-6749

Journal article

Olszewska W, Suezer Y, Sutter G, Openshaw PJMet al., 2004, Protective and disease-enhancing immune responses induced by recombinant modified vaccinia Ankara (MVA) expressing respiratory syncytial virus proteins, VACCINE, Vol: 23, Pages: 215-221, ISSN: 0264-410X

Journal article

Schmidt AC, Johnson TR, Openshaw PJM, Braciale TJ, Falsey AR, Anderson LJ, Wertz GW, Groothuis JR, Prince GA, Melero JA, Graham BSet al., 2004, Respiratory syncytial virus and other pneumoviruses: a review of the international symposium-RSV 2003, VIRUS RESEARCH, Vol: 106, Pages: 1-13, ISSN: 0168-1702

Journal article

Maher CF, Hussell T, Blair E, Ring CJA, Openshaw PJMet al., 2004, Recombinant respiratory syncytial virus lacking secreted glycoprotein G is attenuated, non-pathogenic but induces protective immunity, MICROBES AND INFECTION, Vol: 6, Pages: 1049-1055, ISSN: 1286-4579

Journal article

Bartholdy C, Olszewska W, Stryhn A, Thomsen AR, Openshaw PJMet al., 2004, Gene-gun DNA vaccination aggravates respiratory syncytial virus-induced pneumonitis, JOURNAL OF GENERAL VIROLOGY, Vol: 85, Pages: 3017-3026, ISSN: 0022-1317

Journal article

Regner M, Culley F, Fontannaz P, Hu KF, Morein B, Lambert PH, Openshaw P, Siegrist CAet al., 2004, Safety and efficacy of immune-stimulating complex-based antigen delivery systems for neonatal immunisation against respiratory syncytial virus infection, MICROBES AND INFECTION, Vol: 6, Pages: 666-675, ISSN: 1286-4579

Journal article

Olszewska W, Helson R, Openshaw PJM, 2004, Vaccines for the prevention of respiratory viral infections: problems and current status, EXPERT OPINION ON INVESTIGATIONAL DRUGS, Vol: 13, Pages: 681-689, ISSN: 1354-3784

Journal article

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