Imperial College London

Peter Openshaw - Professor of Experimental Medicine

Faculty of MedicineNational Heart & Lung Institute

Senior Consul, Professor of Experimental Medicine



+44 (0)20 7594 3854p.openshaw Website CV




Ms Gale Lewis +44 (0)20 7594 0944




353Norfolk PlaceSt Mary's Campus






BibTex format

author = {Shi, T and Denouel, A and Tietjen, AK and Lee, JW and Falsey, AR and Demont, C and Nyawanda, BO and Cai, B and Fuentes, R and Stoszek, SK and Openshaw, P and Campbell, H and Nair, H and RESCEU, Investigators},
doi = {infdis/jiz053},
journal = {Journal of Infectious Diseases},
pages = {S570--S576},
title = {Global and regional burden of hospital admissions for pneumonia in older adults: A systematic review and meta-analysis},
url = {},
volume = {222},
year = {2020}

RIS format (EndNote, RefMan)

AB - Pneumonia constitutes a substantial disease burden among adults overall and those who are elderly. We aimed to identify all studies investigating the disease burden among older adults (age, ≥65 years) admitted to the hospital with pneumonia. We estimated the hospital admission rate and in-hospital case-fatality ratio (CFR) of pneumonia in older adults, stratified by age and economic status (industrialized vs developing), with data from a systematic review of studies published from 1996 through 2017 and from 8 unpublished population-based studies. We applied these rate estimates to population estimates for 2015 to calculate the global and regional burden in older adults who would have been admitted to the hospital with pneumonia that year. We estimated the number of in-hospital pneumonia deaths by combining in-hospital CFRs with hospital admission estimates from hospital-based studies. We identified 109 eligible studies; 73 used clinical pneumonia as the case definition, and 36 used radiologically confirmed pneumonia as the case definition. We estimated that, in 2015, 6.8 million episodes (uncertainty range [UR], 5.8-8.0 episodes) of clinical pneumonia resulted in hospital admissions of older adults worldwide. The hospital admission rate increased with advancing age and was higher in men. The total disease burden was likely underestimated when using the definition of radiologically confirmed pneumonia. Based on data from 52 hospital studies reporting data on pneumonia mortality, we estimated that about 1.1 million in-hospital deaths (UR, 0.9-1.4 in-hospital deaths) occurred among older adults. The burden of pneumonia requiring hospitalization among older adults is substantial. Appropriate prevention and management strategies should be developed to reduce its impact.
AU - Shi,T
AU - Denouel,A
AU - Tietjen,AK
AU - Lee,JW
AU - Falsey,AR
AU - Demont,C
AU - Nyawanda,BO
AU - Cai,B
AU - Fuentes,R
AU - Stoszek,SK
AU - Openshaw,P
AU - Campbell,H
AU - Nair,H
AU - RESCEU,Investigators
DO - infdis/jiz053
EP - 576
PY - 2020///
SN - 0022-1899
SP - 570
TI - Global and regional burden of hospital admissions for pneumonia in older adults: A systematic review and meta-analysis
T2 - Journal of Infectious Diseases
UR -
UR -
UR -
VL - 222
ER -