Imperial College London

Peter Openshaw - Professor of Experimental Medicine

Faculty of MedicineNational Heart & Lung Institute

Senior Consul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wiseman:2020:infdis/jiaa063,
author = {Wiseman, DJ and Thwaites, RS and Drysdale, SB and Janet, S and Donaldson, GC and Wedzicha, JA and Openshaw, PJ and RESCEU, Investigators},
doi = {infdis/jiaa063},
journal = {Journal of Infectious Diseases},
pages = {S584--S591},
title = {Immunological and inflammatory biomarkers of susceptibility and severity in adult respiratory syncytial virus infections},
url = {http://dx.doi.org/10.1093/infdis/jiaa063},
volume = {222},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BACKGROUND: . Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in young infants. However, it is also a significant pathogen in older adults. Validated biomarkers of RSV disease severity would benefit diagnostics, treatment decisions, and prophylactic interventions. This review summarizes knowledge of biomarkers for RSV disease in adults. METHODS: A literature review was performed using Ovid Medline, Embase, Global health, Scopus, and Web of Science for articles published 1946-October 2016. Nine articles were identified plus 9 from other sources. RESULTS: From observational studies of natural infection and challenge studies in volunteers, biomarkers of RSV susceptibility or disease severity in adults were: (1) lower anti-RSV neutralizing antibodies, where neutralizing antibody (and local IgA) may be a correlate of susceptibility/severity; (2) RSV-specific CD8+ T cells in bronchoalveolar lavage fluid preinfection (subjects with higher levels had less severe illness); and (3) elevated interleukin-6 (IL-6), IL-8, and myeloperoxidase levels in the airway are indicative of severe infection. CONCLUSIONS: Factors determining susceptibility to and severity of RSV disease in adults have not been well defined. Respiratory mucosal antibodies and CD8+T cells appear to contribute to preventing infection and modulation of disease severity. Studies of RSV pathogenesis in at-risk populations are needed.
AU - Wiseman,DJ
AU - Thwaites,RS
AU - Drysdale,SB
AU - Janet,S
AU - Donaldson,GC
AU - Wedzicha,JA
AU - Openshaw,PJ
AU - RESCEU,Investigators
DO - infdis/jiaa063
EP - 591
PY - 2020///
SN - 0022-1899
SP - 584
TI - Immunological and inflammatory biomarkers of susceptibility and severity in adult respiratory syncytial virus infections
T2 - Journal of Infectious Diseases
UR - http://dx.doi.org/10.1093/infdis/jiaa063
UR - https://www.ncbi.nlm.nih.gov/pubmed/32227102
UR - https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiaa063/5813536
UR - http://hdl.handle.net/10044/1/77886
VL - 222
ER -