Imperial College London

Peter Openshaw - Professor of Experimental Medicine

Faculty of MedicineNational Heart & Lung Institute

Senior Consul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pollard:2020:10.1016/j.biologicals.2020.04.004,
author = {Pollard, AJ and Sauerwein, R and Baay, M and Neels, P and HCT3, speakers and session chairs},
doi = {10.1016/j.biologicals.2020.04.004},
journal = {Biologicals},
pages = {41--52},
title = {Third human challenge trial conference, Oxford, United Kingdom, February 6-7, 2020, a meeting report.},
url = {http://dx.doi.org/10.1016/j.biologicals.2020.04.004},
volume = {66},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The third Human Challenge Trial Meeting brought together a broad range of international stakeholders, including academia, regulators, funders and industry, with a considerable delegation from Low- and Middle-Income Countries. Controlled human infection models (CHIMs) can be helpful to study pathogenesis and for the development of vaccines. As challenge agents are used to infect healthy volunteers, ethical considerations include that the challenge studies need to be safe and results should be meaningful. The meeting provided a state-of-the-art overview on a wide range of CHIMs, including viral, bacterial and parasitic challenge agents. Recommendations included globally aligned guidance documents for CHIM studies; further definition of a CHIM, based on the challenge agent used; standardization of methodology and study endpoints; capacity building in Low- and Middle-Income Countries, in performance as well as regulation of CHIM studies; guidance on compensation for participation in CHIM studies; and preparation of CHIM studies, with strong engagement with stakeholders.
AU - Pollard,AJ
AU - Sauerwein,R
AU - Baay,M
AU - Neels,P
AU - HCT3,speakers and session chairs
DO - 10.1016/j.biologicals.2020.04.004
EP - 52
PY - 2020///
SP - 41
TI - Third human challenge trial conference, Oxford, United Kingdom, February 6-7, 2020, a meeting report.
T2 - Biologicals
UR - http://dx.doi.org/10.1016/j.biologicals.2020.04.004
UR - https://www.ncbi.nlm.nih.gov/pubmed/32505512
VL - 66
ER -