Imperial College London

Peter Openshaw - Professor of Experimental Medicine

Faculty of MedicineNational Heart & Lung Institute

Senior Consul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Habibi:2020:10.1126/science.aba9301,
author = {Habibi, MS and Thwaites, RS and Chang, M and Jozwik, A and Paras, A and Kirsebom, F and Varese, A and Owen, A and Cuthbertson, L and James, P and Tunstall, T and Nickle, D and Hansel, TT and Moffatt, MF and Johansson, C and Chiu, C and Openshaw, PJM},
doi = {10.1126/science.aba9301},
journal = {Science},
title = {Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection.},
url = {http://dx.doi.org/10.1126/science.aba9301},
volume = {370},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The variable outcome of viral exposure is only partially explained by known factors. We administered respiratory syncytial virus (RSV) to 58 volunteers, of whom 57% became infected. Mucosal neutrophil activation before exposure was highly predictive of symptomatic RSV disease. This was associated with a rapid, presymptomatic decline in mucosal interleukin-17A (IL-17A) and other mediators. Conversely, those who resisted infection showed presymptomatic activation of IL-17- and tumor necrosis factor-related pathways. Vulnerability to infection was not associated with baseline microbiome but was reproduced in mice by preinfection chemokine-driven airway recruitment of neutrophils, which caused enhanced disease mediated by pulmonary CD8+ T cell infiltration. Thus, mucosal neutrophilic inflammation at the time of RSV exposure enhances susceptibility, revealing dynamic, time-dependent local immune responses before symptom onset and explaining the as-yet unpredictable outcomes of pathogen exposure.
AU - Habibi,MS
AU - Thwaites,RS
AU - Chang,M
AU - Jozwik,A
AU - Paras,A
AU - Kirsebom,F
AU - Varese,A
AU - Owen,A
AU - Cuthbertson,L
AU - James,P
AU - Tunstall,T
AU - Nickle,D
AU - Hansel,TT
AU - Moffatt,MF
AU - Johansson,C
AU - Chiu,C
AU - Openshaw,PJM
DO - 10.1126/science.aba9301
PY - 2020///
TI - Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection.
T2 - Science
UR - http://dx.doi.org/10.1126/science.aba9301
UR - https://www.ncbi.nlm.nih.gov/pubmed/33033192
UR - http://hdl.handle.net/10044/1/82442
VL - 370
ER -