Imperial College London

Peter Openshaw - Professor of Experimental Medicine

Faculty of MedicineNational Heart & Lung Institute

Senior Consul, Professor of Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

353Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Peng:2020:10.1038/s41590-020-0782-6,
author = {Peng, Y and Mentzer, AJ and Liu, G and Yao, X and Yin, Z and Dong, D and Dejnirattisai, W and Rostron, T and Supasa, P and Liu, C and López-Camacho, C and Slon-Campos, J and Zhao, Y and Stuart, DI and Paesen, GC and Grimes, JM and Antson, AA and Bayfield, OW and Hawkins, DEDP and Ker, D and Wang, B and Turtle, L and Subramaniam, K and Thomson, P and Zhang, P and Dold, C and Ratcliff, J and Simmonds, P and de, Silva T and Sopp, P and Wellington, D and Rajapaksa, U and Chen, Y and Salio, M and Napolitani, G and Paes, W and Borrow, P and Kessler, BM and Fry, JW and Schwabe, NF and Semple, MG and Baillie, JK and Moore, SC and Openshaw, PJM and Ansari, MA and Dunachie, S and Barnes, E and Frater, J and Kerr, G and Goulder, P and Lockett, T and Levin, R and Zhang, Y and Jing, R and Ho, L and Barnes, E and Dong, D and Dong, T and Dunachie, S and Frater, J and Goulder, P and Kerr, G and Klenerman, P and Liu, G and McMichael, A and Napolitani, G and Ogg, G and Peng, Y and Salio, M and Yao, X an},
doi = {10.1038/s41590-020-0782-6},
journal = {Nature Immunology},
title = {Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19},
url = {http://dx.doi.org/10.1038/s41590-020-0782-6},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-γ-based assays with peptides spanning SARS-CoV-2 except ORF1. The breadth and magnitude of T cell responses were significantly higher in severe as compared with mild cases. Total and spike-specific T cell responses correlated with spike-specific antibody responses. We identified 41 peptides containing CD4+ and/or CD8+ epitopes, including six immunodominant regions. Six optimized CD8+ epitopes were defined, with peptide–MHC pentamer-positive cells displaying the central and effector memory phenotype. In mild cases, higher proportions of SARS-CoV-2-specific CD8+ T cells were observed. The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design.
AU - Peng,Y
AU - Mentzer,AJ
AU - Liu,G
AU - Yao,X
AU - Yin,Z
AU - Dong,D
AU - Dejnirattisai,W
AU - Rostron,T
AU - Supasa,P
AU - Liu,C
AU - López-Camacho,C
AU - Slon-Campos,J
AU - Zhao,Y
AU - Stuart,DI
AU - Paesen,GC
AU - Grimes,JM
AU - Antson,AA
AU - Bayfield,OW
AU - Hawkins,DEDP
AU - Ker,D
AU - Wang,B
AU - Turtle,L
AU - Subramaniam,K
AU - Thomson,P
AU - Zhang,P
AU - Dold,C
AU - Ratcliff,J
AU - Simmonds,P
AU - de,Silva T
AU - Sopp,P
AU - Wellington,D
AU - Rajapaksa,U
AU - Chen,Y
AU - Salio,M
AU - Napolitani,G
AU - Paes,W
AU - Borrow,P
AU - Kessler,BM
AU - Fry,JW
AU - Schwabe,NF
AU - Semple,MG
AU - Baillie,JK
AU - Moore,SC
AU - Openshaw,PJM
AU - Ansari,MA
AU - Dunachie,S
AU - Barnes,E
AU - Frater,J
AU - Kerr,G
AU - Goulder,P
AU - Lockett,T
AU - Levin,R
AU - Zhang,Y
AU - Jing,R
AU - Ho,L
AU - Barnes,E
AU - Dong,D
AU - Dong,T
AU - Dunachie,S
AU - Frater,J
AU - Goulder,P
AU - Kerr,G
AU - Klenerman,P
AU - Liu,G
AU - McMichael,A
AU - Napolitani,G
AU - Ogg,G
AU - Peng,Y
AU - Salio,M
AU - Yao,X
AU - Yin,Z
AU - Kenneth,Baillie J
AU - Klenerman,P
AU - Mentzer,AJ
AU - Moore,SC
AU - Openshaw,PJM
AU - Semple,MG
AU - Stuart,DI
AU - Turtle,L
AU - Cornall,RJ
AU - Conlon,CP
AU - Klenerman,P
AU - Screaton,GR
AU - Mongkolsapaya,J
AU - McMichael,A
AU - Knight,JC
AU - Ogg,G
AU - Dong,T
AU - Oxford,Immunology Network Covid-19 Response T cell Consortium
AU - ISARIC4C,Investigators
DO - 10.1038/s41590-020-0782-6
PY - 2020///
SN - 1529-2916
TI - Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19
T2 - Nature Immunology
UR - http://dx.doi.org/10.1038/s41590-020-0782-6
UR - https://doi.org/10.1038/s41590-020-0782-6
ER -