Imperial College London

Peter Openshaw - Professor of Experimental Medicine

Faculty of MedicineNational Heart & Lung Institute

Senior Consul, Professor of Experimental Medicine
 
 
 
//

Contact

 

+44 (0)20 7594 3854p.openshaw Website CV

 
 
//

Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
//

Location

 

353Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Drake:2020:10.1164/rccm.202007-2794OC,
author = {Drake, TM and Docherty, AB and Harrison, EM and Quint, JK and Adamali, H and Agnew, S and Babu, S and Barber, CM and Barratt, S and Bendstrup, E and Bianchi, S and Castillo, Villegas D and Chaudhuri, N and Chua, F and Coker, R and Chang, W and Crawshaw, A and Crowley, LE and Dosanjh, D and Fiddler, CA and Forrest, IA and George, PM and Gibbons, MA and Groom, K and Haney, S and Hart, SP and Heiden, E and Henry, M and Ho, L-P and Hoyles, RK and Hutchinson, J and Hurley, K and Jones, MG and Jones, S and Kokosi, M and Kreuter, M and Mackay, LS and Mahendran, S and Margaritopoulos, G and Molina-Molina, M and Molyneaux, PL and O'Brien, A and O'Reilly, K and Packham, A and Parfrey, H and Poletti, V and Porter, JC and Renzoni, E and Rivera-Ortega, P and Russell, A-M and Saini, G and Spencer, LG and Stella, GM and Stone, H and Sturney, S and Thickett, D and Thillai, M and Wallis, T and Ward, K and Wells, AU and West, A and Wickremasinghe, M and Woodhead, F and Hearson, G and Howard, L and Baill},
doi = {10.1164/rccm.202007-2794OC},
journal = {American Journal of Respiratory and Critical Care Medicine},
title = {Outcome of hospitalization for COVID-19 in patients with interstitial lung disease: an international multicenter study.},
url = {http://dx.doi.org/10.1164/rccm.202007-2794OC},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - RATIONALE: The impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established. OBJECTIVES: To assess outcomes in patients with ILD hospitalized for COVID-19 versus those without ILD in a contemporaneous age, sex and comorbidity matched population. METHODS: An international multicenter audit of patients with a prior diagnosis of ILD admitted to hospital with COVID-19 between 1 March and 1 May 2020 was undertaken and compared with patients, without ILD obtained from the ISARIC 4C cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished IPF from non-IPF ILD and used lung function to determine the greatest risks of death. MEASUREMENTS AND MAIN RESULTS: Data from 349 patients with ILD across Europe were included, of whom 161 were admitted to hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity-score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching ILD patients with COVID-19 had higher mortality (HR 1.60, Confidence Intervals 1.17-2.18 p=0.003) compared with age, sex and co-morbidity matched controls without ILD. Patients with a Forced Vital Capacity (FVC) of <80% had an increased risk of death versus patients with FVC ≥80% (HR 1.72, 1.05-2.83). Furthermore, obese patients with ILD had an elevated risk of death (HR 2.27, 1.39-3.71). CONCLUSIONS: Patients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity. Stringent precautions should be taken to avoid COVID-19 in patients with ILD. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
AU - Drake,TM
AU - Docherty,AB
AU - Harrison,EM
AU - Quint,JK
AU - Adamali,H
AU - Agnew,S
AU - Babu,S
AU - Barber,CM
AU - Barratt,S
AU - Bendstrup,E
AU - Bianchi,S
AU - Castillo,Villegas D
AU - Chaudhuri,N
AU - Chua,F
AU - Coker,R
AU - Chang,W
AU - Crawshaw,A
AU - Crowley,LE
AU - Dosanjh,D
AU - Fiddler,CA
AU - Forrest,IA
AU - George,PM
AU - Gibbons,MA
AU - Groom,K
AU - Haney,S
AU - Hart,SP
AU - Heiden,E
AU - Henry,M
AU - Ho,L-P
AU - Hoyles,RK
AU - Hutchinson,J
AU - Hurley,K
AU - Jones,MG
AU - Jones,S
AU - Kokosi,M
AU - Kreuter,M
AU - Mackay,LS
AU - Mahendran,S
AU - Margaritopoulos,G
AU - Molina-Molina,M
AU - Molyneaux,PL
AU - O'Brien,A
AU - O'Reilly,K
AU - Packham,A
AU - Parfrey,H
AU - Poletti,V
AU - Porter,JC
AU - Renzoni,E
AU - Rivera-Ortega,P
AU - Russell,A-M
AU - Saini,G
AU - Spencer,LG
AU - Stella,GM
AU - Stone,H
AU - Sturney,S
AU - Thickett,D
AU - Thillai,M
AU - Wallis,T
AU - Ward,K
AU - Wells,AU
AU - West,A
AU - Wickremasinghe,M
AU - Woodhead,F
AU - Hearson,G
AU - Howard,L
AU - Baillie,JK
AU - Openshaw,PJM
AU - Semple,MG
AU - Stewart,I
AU - Jenkins,RG
AU - ISARIC4C,Investigators
DO - 10.1164/rccm.202007-2794OC
PY - 2020///
SN - 1073-449X
TI - Outcome of hospitalization for COVID-19 in patients with interstitial lung disease: an international multicenter study.
T2 - American Journal of Respiratory and Critical Care Medicine
UR - http://dx.doi.org/10.1164/rccm.202007-2794OC
UR - https://www.ncbi.nlm.nih.gov/pubmed/33007173
UR - https://www.atsjournals.org/doi/10.1164/rccm.202007-2794OC
UR - http://hdl.handle.net/10044/1/83038
ER -