Publications
447 results found
Tregoning JS, Yamaguchi Y, Harker J, et al., 2008, The role of T cells in the enhancement of respiratory syncytial virus infection severity during adult reinfection of neonatally sensitized mice, JOURNAL OF VIROLOGY, Vol: 82, Pages: 4115-4124, ISSN: 0022-538X
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- Citations: 96
Openshaw PJM, 2008, Susan Elizabeth Openshaw (nee Scott Stokes) - Obituary, BRITISH MEDICAL JOURNAL, Vol: 336, Pages: 621-621, ISSN: 0959-8146
Helson R, Olszewska W, Singh M, et al., 2008, Polylactide-co-glycolide (PLG) microparticles modify the immune response to DNA vaccination, VACCINE, Vol: 26, Pages: 753-761, ISSN: 0264-410X
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- Citations: 20
Harker J, Bukreyev A, Collins PL, et al., 2007, Virally delivered Cytokines alter the immune response to future lung infections, JOURNAL OF VIROLOGY, Vol: 81, Pages: 13105-13111, ISSN: 0022-538X
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- Citations: 25
Samarasinghe SR, Nawroly N, Karlsson H, et al., 2007, Functional characterisaition of alloreactive T-Cells identifies CD25 and CD71 as the optimal targets for allodepletion strategies, 49th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 649A-649A, ISSN: 0006-4971
Dodd JS, Clark D, O'Brien D, et al., 2007, IL-21 depletion exacerbates augmented respiratory syncytial virus (RSV) disease by deregulating control of dendritic cell: CD4 T cell stimulation, Annual Congress of the British-Society-of-Immunology, Publisher: BLACKWELL PUBLISHING, Pages: 14-14, ISSN: 0019-2805
Wythe SE, Dodd JS, Openshaw PJ, et al., 2007, Differential expression of CD40, OX40L & PDL2 on lung dendritic cells in polarised immune responses to Respiratory Syncytial Virus (RSV), Annual Congress of the British-Society-of-Immunology, Publisher: BLACKWELL PUBLISHING, Pages: 15-15, ISSN: 0019-2805
Samarasinghe S, Karlsson H, Nawroly N, et al., 2007, Enhanced depletion of alloreactive T cells using combined CD25/71 immunomagnetic selection, Tandem BMT Meeting 2007, Publisher: ELSEVIER SCIENCE INC, Pages: 21-21, ISSN: 1083-8791
Moghaddam A, Olszewska W, Wang B, et al., 2006, A potential molecular mechanism for hypersensitivity caused by formalin- inactivated vaccines, NATURE MEDICINE, Vol: 12, Pages: 905-907, ISSN: 1078-8956
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- Citations: 170
Culley FJ, Pennycook AAJ, Tregoning JS, et al., 2006, Role of CCL5 (RANTES) in viral lung disease, JOURNAL OF VIROLOGY, Vol: 80, Pages: 8151-8157, ISSN: 0022-538X
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- Citations: 95
Smyth RL, Openshaw PJM, 2006, Bronchiolitis, LANCET, Vol: 368, Pages: 312-322, ISSN: 0140-6736
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- Citations: 314
Openshaw P, 2006, T cells take the inside track, NATURE MEDICINE, Vol: 12, Pages: 614-615, ISSN: 1078-8956
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- Citations: 1
Culley FJ, Pennycook AMJ, Tregoning JS, et al., 2006, Differential chemokine expression following respiratory virus infection reflects Th1-or Th2-based immunopathology, Journal of Virology, Vol: 80, Pages: 4521-4527, ISSN: 1098-5514
Wilkinson TM, Donaldson GC, Johnston SL, et al., 2006, Respiratory syncytial virus, airway inflammation, and FEV1 decline in patients with chronic obstructive pulmonary disease, American Journal of Respiratory and Critical Care Medicine, Vol: 173, Pages: 871-876, ISSN: 1073-449X
Dodd JS, Korpis C, Openshaw PJM, 2005, IL-21 reduces immunopathology in respiratory viral disease in a T cell-dependent manner, IMMUNOLOGY, Vol: 116, Pages: 84-84, ISSN: 0019-2805
Harker J, Tregoning JS, Bukreyev A, et al., 2005, Contrasting effects of virally expressed IFN-γ and IL-4 in neonatal and adult mice, IMMUNOLOGY, Vol: 116, Pages: 25-25, ISSN: 0019-2805
Tourdot S, Hussell T, Openshaw PJM, et al., 2005, RSV infection provokes airway remodelling in non-sensitised allergen challenged mice, IMMUNOLOGY, Vol: 116, Pages: 53-53, ISSN: 0019-2805
Godkin A, Openshaw P, Thomas HC, 2005, Immune tolerance to hepatitis C virus acquired during engraftment of bone marrow transplant, JOURNAL OF VIRAL HEPATITIS, Vol: 12, Pages: 604-608, ISSN: 1352-0504
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- Citations: 2
Beyer M, Wang HW, Peters N, et al., 2005, The beta2 integrin CDIIc distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo, RESPIRATORY RESEARCH, Vol: 6, ISSN: 1465-9921
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- Citations: 43
Openshaw PJM, Tregoning JS, 2005, Immune responses and disease enhancement during respiratory syncytial virus infection, CLINICAL MICROBIOLOGY REVIEWS, Vol: 18, Pages: 541-+, ISSN: 0893-8512
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- Citations: 229
, 2005, Methods of modifying an antigen to modify the Th2-type bias of the Th1/Th2-type immune response of an animalInternational (PCT) patent with Publication Number (, UK patent 0326439 (7WO2005/049074)
Matthews SP, Tregoning JS, Coyle AJ, et al., 2005, Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection, JOURNAL OF VIROLOGY, Vol: 79, Pages: 2050-2057, ISSN: 0022-538X
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- Citations: 46
Openshaw PJM, 2005, Antiviral immune responses and lung inflammation after respiratory syncytial virus infection., Proc Am Thorac Soc, Vol: 2, Pages: 121-125, ISSN: 1546-3222
Respiratory syncytial virus (RSV) is one of the commonest and most troublesome viruses of infancy. It causes most cases of bronchiolitis, which is associated with wheezing in later childhood. In primary infection, the peak of disease coincides not with the peak of viral replication but with the development of specific T and B cell responses. This immune response is apparently responsible for much of the disease. Animal models clearly show that a range of immune responses can enhance disease severity, particularly after vaccination with formalin-inactivated RSV. Prior immune sensitization leads to exuberant chemokine production, an excessive cellular influx, and an overabundance of cytokines during RSV challenge. The inflammatory host response to viral infection may be relevant not only to childhood bronchiolitis, but also to obstructive lung diseases in adults.
Openshaw PJM, Tregoning J, Harker J, 2005, RSV 2005: Global impact, changing concepts, and new challenges., Viral Immunol, Vol: 18, Pages: 749-751, ISSN: 0882-8245
Openshaw PJM, Yamaguchi Y, Tregoning JS, 2004, Childhood infections, the developing immune system, and the origins of asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 114, Pages: 1275-1277, ISSN: 0091-6749
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- Citations: 38
Olszewska W, Suezer Y, Sutter G, et al., 2004, Protective and disease-enhancing immune responses induced by recombinant modified vaccinia Ankara (MVA) expressing respiratory syncytial virus proteins, VACCINE, Vol: 23, Pages: 215-221, ISSN: 0264-410X
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- Citations: 35
Schmidt AC, Johnson TR, Openshaw PJM, et al., 2004, Respiratory syncytial virus and other pneumoviruses: a review of the international symposium-RSV 2003, VIRUS RESEARCH, Vol: 106, Pages: 1-13, ISSN: 0168-1702
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- Citations: 19
Bartholdy C, Olszewska W, Stryhn A, et al., 2004, Gene-gun DNA vaccination aggravates respiratory syncytial virus-induced pneumonitis, JOURNAL OF GENERAL VIROLOGY, Vol: 85, Pages: 3017-3026, ISSN: 0022-1317
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- Citations: 15
Maher CF, Hussell T, Blair E, et al., 2004, Recombinant respiratory syncytial virus lacking secreted glycoprotein G is attenuated, non-pathogenic but induces protective immunity, MICROBES AND INFECTION, Vol: 6, Pages: 1049-1055, ISSN: 1286-4579
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- Citations: 27
Ison MG, Johnston SL, Openshaw P, et al., 2004, Current research on respiratory viral infections: Fifth International Symposium., Antiviral Res, Vol: 62, Pages: 75-110, ISSN: 0166-3542
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