Publications
449 results found
Hussell T, Spender LC, Georgiou A, et al., 1996, Th1 and Th2 cytokine induction in pulmonary T cells during infection with respiratory syncytial virus, JOURNAL OF GENERAL VIROLOGY, Vol: 77, Pages: 2447-2455, ISSN: 0022-1317
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- Citations: 136
Hussell T, Openshaw PJM, 1996, Immunological determinants of disease caused by respiratory syncytial virus, TRENDS IN MICROBIOLOGY, Vol: 4, Pages: 299-300, ISSN: 0966-842X
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- Citations: 1
MireSluis AR, Das RG, Thorpe R, et al., 1996, Implications for the assay and biological activity of interleukin-4 - Results of a WHO international collaborative study, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 194, Pages: 13-25, ISSN: 0022-1759
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- Citations: 6
MireSluis AR, Das RG, Thorpe R, et al., 1996, Implications for the assay and biological properties of interleukin-3 - Results of a WHO international collaborative study, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 194, Pages: 1-12, ISSN: 0022-1759
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- Citations: 5
Vicari AP, Mocci S, Openshaw P, et al., 1996, Mouse gamma delta TCR(+)NK1.1(+) thymocytes specifically produce interleukin-4, are major histocompatibility complex class I independent, and are developmentally related to alpha beta TCR(+)NK1.1(+) thymocytes, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 26, Pages: 1424-1429, ISSN: 0014-2980
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- Citations: 64
Murphy E, Shibuya K, Hosken N, et al., 1996, Reversibility of T helper 1 and 2 populations is lost after long-term stimulation, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 183, Pages: 901-913, ISSN: 0022-1007
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- Citations: 380
Openshaw PJM, Spender LC, Hussell T, 1996, Beneficial and harmful immune responses in the respiratory tract, 8th International Congress of Mucosal Immunology, Publisher: ACADEMIC PRESS INC, Pages: 449-457
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- Citations: 2
OPENSHAW P, MURPHY EE, HOSKEN NA, et al., 1995, HETEROGENEITY OF INTRACELLULAR CYTOKINE SYNTHESIS AT THE SINGLE-CELL LEVEL IN POLARIZED T-HELPER-1 AND T-HELPER-2 POPULATIONS, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 182, Pages: 1357-1367, ISSN: 0022-1007
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- Citations: 504
OPENSHAW PJM, 1995, IMMUNITY AND IMMUNOPATHOLOGY TO RESPIRATORY SYNCYTIAL VIRUS - THE MOUSE MODEL, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 152, Pages: S59-S62, ISSN: 1073-449X
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- Citations: 99
OPENSHAW PJM, 1995, IMMUNOPATHOLOGICAL MECHANISMS IN RESPIRATORY SYNCYTIAL VIRUS-DISEASE, SPRINGER SEMINARS IN IMMUNOPATHOLOGY, Vol: 17, Pages: 187-201, ISSN: 0344-4325
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- Citations: 74
OPENSHAW PJM, 1995, DISEASE ENHANCEMENT BY IMMUNITY TO RESPIRATORY SYNCYTIAL (RS) VIRUS, JOURNAL OF CELLULAR BIOCHEMISTRY, Pages: 275-275, ISSN: 0730-2312
ODONNELL DR, GEORGIOU A, MEE PJ, et al., 1995, NORMAL PATTERNS OF LUNG-DISEASE AND VIRUS CLEARANCE IN RESPIRATORY SYNCYTIAL VIRUS-INFECTED MICE DEFICIENT OF IL-3, JOURNAL OF CELLULAR BIOCHEMISTRY, Pages: 284-284, ISSN: 0730-2312
OPENSHAW PJM, ODONNELL DR, 1994, ASTHMA AND THE COMMON COLD - CAN VIRUSES IMITATE WORMS, THORAX, Vol: 49, Pages: 101-103, ISSN: 0040-6376
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- Citations: 26
ALWAN WH, KOZLOWSKA WJ, OPENSHAW PJM, 1994, DISTINCT TYPES OF LUNG-DISEASE CAUSED BY FUNCTIONAL SUBSETS OF ANTIVIRAL T-CELLS, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 179, Pages: 81-89, ISSN: 0022-1007
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- Citations: 262
ALWAN WH, RECORD FM, OPENSHAW PJM, 1993, PHENOTYPIC AND FUNCTIONAL-CHARACTERIZATION OF T-CELL LINES SPECIFIC FOR INDIVIDUAL RESPIRATORY SYNCYTIAL VIRUS PROTEINS, JOURNAL OF IMMUNOLOGY, Vol: 150, Pages: 5211-5218, ISSN: 0022-1767
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- Citations: 106
OPENSHAW PJM, KOZLOWSKA W, ALWAN WH, 1993, T-CELLS SPECIFIC TO SINGLE VIRAL-PROTEINS CAUSE DISTINCT PATTERNS OF PROTECTION AND DISEASE, JOURNAL OF CELLULAR BIOCHEMISTRY, Pages: 68-68, ISSN: 0730-2312
RAPECKI S, MCILROY D, OPENSHAW P, 1993, T-LYMPHOCYTE SUBSETS IN LUNG INFECTIONS - GAMMA-DELTA T-CELLS ARE INDUCED BY NONVIRAL PATHOGENS, JOURNAL OF CELLULAR BIOCHEMISTRY, Pages: 53-53, ISSN: 0730-2312
ALWAN WH, OPENSHAW PJM, 1993, DISTINCT PATTERNS OF T-CELL AND B-CELL IMMUNITY TO RESPIRATORY SYNCYTIAL VIRUS-INDUCED BY INDIVIDUAL VIRAL-PROTEINS, VACCINE, Vol: 11, Pages: 431-437, ISSN: 0264-410X
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- Citations: 70
OPENSHAW P, 1992, BARCELONAS ASTHMA EPIDEMICS, THORAX, Vol: 47, Pages: 668-668, ISSN: 0040-6376
Openshaw P, 1992, Barcelona's asthma epidemics., Thorax, Vol: 47, ISSN: 0040-6376
Alwan WH, Record FM, Openshaw PJ, 1992, CD4+ T cells clear virus but augment disease in mice infected with respiratory syncytial virus. Comparison with the effects of CD8+ T cells., Clinical and experimental immunology, Vol: 88, Pages: 527-536, ISSN: 0009-9104
Respiratory syncytial (RS) virus-specific T cell lines were derived from the spleens of BALB/c mice primed by intranasal infection with RS virus. The lines were expanded by repeated antigenic stimulation in vitro, and separated into CD4+ and CD8+ T cell-enriched fractions by immunomagnetic adhesion. The effects of passive transfer of these fractions into RS virus infected mice were observed. The most severe immunopathological changes were seen in mice receiving CD4+ cells. Transfer of CD4+, CD8+ or both cell fractions caused RS virus-infected mice to become ill and lose weight. Both cell lines caused an increase in the severity of lung pathology (as monitored by bronchoalveolar lavage) with the appearance of lung haemorrhage and polymorphonuclear cell efflux. In addition, recipients of CD4+ cells developed striking pulmonary eosinophilia. In CD4+ cell recipients, 5 x 10(5) cells were sufficient to decrease lung virus titre, whereas 2 x 10(6) CD8+ cells were needed to produce a similar effect. The unseparated T cell line and the CD4+ cell fraction secreted significant amounts of IL-3, IL-4 and IL-5 (P less than 0.001). High levels of IL-2 were produced only by the unseparated T cell line. The CD8+ cell fraction secreted IL-3 only. The results show that, cell-for-cell, CD4+ cells are more anti-viral and more immunopathogenic than CD8+ cells in RS virus infected mice. Such effects may have contributed to the augmented disease seen in some infants vaccinated against RS virus.
CHERRIE AH, ANDERSON K, WERTZ GW, et al., 1992, HUMAN CYTOTOXIC T-CELLS STIMULATED BY ANTIGEN ON DENDRITIC CELLS RECOGNIZE THE N, SH, F, M, 22K, AND 1B PROTEINS OF RESPIRATORY SYNCYTIAL VIRUS, JOURNAL OF VIROLOGY, Vol: 66, Pages: 2102-2110, ISSN: 0022-538X
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- Citations: 108
OPENSHAW PJM, CLARKE SL, RECORD FM, 1992, PULMONARY EOSINOPHILIC RESPONSE TO RESPIRATORY SYNCYTIAL VIRUS-INFECTION IN MICE SENSITIZED TO THE MAJOR SURFACE GLYCOPROTEIN-G, INTERNATIONAL IMMUNOLOGY, Vol: 4, Pages: 493-500, ISSN: 0953-8178
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- Citations: 197
OPENSHAW PJM, RECORD FM, 1992, EPITHELIAL GAMMA-DELTA T-CELLS IN LUNG INFECTIONS, THORAX, Vol: 47, Pages: P253-P253, ISSN: 0040-6376
OPENSHAW PJM, 1991, WHEN WE SNEEZE, DOES THE IMMUNE-SYSTEM CATCH A COLD, BRITISH MEDICAL JOURNAL, Vol: 303, Pages: 935-936, ISSN: 0959-8138
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- Citations: 12
Openshaw PJ, Alwan WH, Cherrie AH, et al., 1991, Accidental infection of laboratory worker with recombinant vaccinia virus., Lancet, Vol: 338, ISSN: 0140-6736
OPENSHAW PJM, ALWAN WH, CHERRIE AH, et al., 1991, ACCIDENTAL INFECTION OF LABORATORY WORKER WITH RECOMBINANT VACCINIA VIRUS, LANCET, Vol: 338, Pages: 459-459, ISSN: 0140-6736
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- Citations: 27
OPENSHAW PJM, 1991, PULMONARY EPITHELIAL T-CELLS INDUCED BY VIRAL-INFECTION EXPRESS T-CELL RECEPTORS-ALPHA-BETA, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 21, Pages: 803-806, ISSN: 0014-2980
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- Citations: 24
OPENSHAW PJM, ANDERSON K, WERTZ GW, et al., 1990, THE 22,000-KILODALTON PROTEIN OF RESPIRATORY SYNCYTIAL VIRUS IS A MAJOR TARGET FOR KD-RESTRICTED CYTOTOXIC LYMPHOCYTES-T FROM MICE PRIMED BY INFECTION, JOURNAL OF VIROLOGY, Vol: 64, Pages: 1683-1689, ISSN: 0022-538X
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- Citations: 93
ASKONAS BA, OPENSHAW PJM, 1989, MHC AND ANTIGEN PRESENTATION, IMMUNOLOGY TODAY, Vol: 10, Pages: 396-397, ISSN: 0167-5699
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- Citations: 5
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