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@article{Docherty:2020:10.1136/bmj.m1985,
author = {Docherty, AB and Harrison, EM and Green, CA and Hardwick, HE and Pius, R and Norman, L and Holden, KA and Read, JM and Dondelinger, F and Carson, G and Merson, L and Lee, J and Plotkin, D and Sigfrid, L and Halpin, S and Jackson, C and Gamble, C and Horby, PW and Nguyen-Van-Tam, JS and Ho, A and Russell, CD and Dunning, J and Openshaw, PJM and Baillie, JK and Semple, MG},
doi = {10.1136/bmj.m1985},
journal = {BMJ},
pages = {1--12},
title = {Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study},
url = {http://dx.doi.org/10.1136/bmj.m1985},
volume = {369},
year = {2020}
}

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TY  - JOUR
AB  - Objective To characterise the clinical features of patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United Kingdom during the growth phase of the first wave of this outbreak who were enrolled in the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK) study, and to explore risk factors associated with mortality in hospital.Design Prospective observational cohort study with rapid data gathering and near real time analysis.Setting 208 acute care hospitals in England, Wales, and Scotland between 6 February and 19 April 2020. A case report form developed by ISARIC and WHO was used to collect clinical data. A minimal follow-up time of two weeks (to 3 May 2020) allowed most patients to complete their hospital admission.Participants 20 133 hospital inpatients with covid-19.Main outcome measures Admission to critical care (high dependency unit or intensive care unit) and mortality in hospital.Results The median age of patients admitted to hospital with covid-19, or with a diagnosis of covid-19 made in hospital, was 73 years (interquartile range 58-82, range 0-104). More men were admitted than women (men 60%, n=12 068; women 40%, n=8065). The median duration of symptoms before admission was 4 days (interquartile range 1-8). The commonest comorbidities were chronic cardiac disease (31%, 5469/17 702), uncomplicated diabetes (21%, 3650/17 599), non-asthmatic chronic pulmonary disease (18%, 3128/17 634), and chronic kidney disease (16%, 2830/17 506); 23% (4161/18 525) had no reported major comorbidity. Overall, 41% (8199/20 133) of patients were discharged alive, 26% (5165/20 133) died, and 34% (6769/20 133) continued to receive care at the reporting date. 17% (3001/18 183) required admission to high dependency or intensive care units; of these, 28% (826/3001) were discharged alive, 32% (958/3001) died, and 41% (1217/3001) continued to receive
AU  - Docherty,AB
AU  - Harrison,EM
AU  - Green,CA
AU  - Hardwick,HE
AU  - Pius,R
AU  - Norman,L
AU  - Holden,KA
AU  - Read,JM
AU  - Dondelinger,F
AU  - Carson,G
AU  - Merson,L
AU  - Lee,J
AU  - Plotkin,D
AU  - Sigfrid,L
AU  - Halpin,S
AU  - Jackson,C
AU  - Gamble,C
AU  - Horby,PW
AU  - Nguyen-Van-Tam,JS
AU  - Ho,A
AU  - Russell,CD
AU  - Dunning,J
AU  - Openshaw,PJM
AU  - Baillie,JK
AU  - Semple,MG
DO  - 10.1136/bmj.m1985
EP  - 12
PY  - 2020///
SN  - 1759-2151
SP  - 1
TI  - Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study
T2  - BMJ
UR  - http://dx.doi.org/10.1136/bmj.m1985
UR  - https://www.bmj.com/content/369/bmj.m1985
UR  - http://hdl.handle.net/10044/1/79468
VL  - 369
ER  -

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Peter Openshaw - Professor of Experimental Medicine

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