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@article{Mehta:2020:10.1016/S2213-2600(20)30267-8,
author = {Mehta, P and Porter, JC and Manson, JJ and Isaacs, JD and Openshaw, PJM and McInnes, IB and Summers, C and Chambers, RC},
doi = {10.1016/S2213-2600(20)30267-8},
journal = {The Lancet Respiratory Medicine},
pages = {822--830},
title = {Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities},
url = {http://dx.doi.org/10.1016/S2213-2600(20)30267-8},
volume = {8},
year = {2020}
}

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TY  - JOUR
AB  - The COVID-19 pandemic is a global public health crisis, with considerable mortality and morbidity exerting pressure on health-care resources, including critical care. An excessive host inflammatory response in a subgroup of patients with severe COVID-19 might contribute to the development of acute respiratory distress syndrome (ARDS) and multiorgan failure. Timely therapeutic intervention with immunomodulation in patients with hyperinflammation could prevent disease progression to ARDS and obviate the need for invasive ventilation. Granulocyte macrophage colony-stimulating factor (GM-CSF) is an immunoregulatory cytokine with a pivotal role in initiation and perpetuation of inflammatory diseases. GM-CSF could link T-cell-driven acute pulmonary inflammation with an autocrine, self-amplifying cytokine loop leading to monocyte and macrophage activation. This axis has been targeted in cytokine storm syndromes and chronic inflammatory disorders. Here, we consider the scientific rationale for therapeutic targeting of GM-CSF in COVID-19-associated hyperinflammation. Since GM-CSF also has a key role in homoeostasis and host defence, we discuss potential risks associated with inhibition of GM-CSF in the context of viral infection and the challenges of doing clinical trials in this setting, highlighting in particular the need for a patient risk-stratification algorithm.
AU  - Mehta,P
AU  - Porter,JC
AU  - Manson,JJ
AU  - Isaacs,JD
AU  - Openshaw,PJM
AU  - McInnes,IB
AU  - Summers,C
AU  - Chambers,RC
DO  - 10.1016/S2213-2600(20)30267-8
EP  - 830
PY  - 2020///
SN  - 2213-2600
SP  - 822
TI  - Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities
T2  - The Lancet Respiratory Medicine
UR  - http://dx.doi.org/10.1016/S2213-2600(20)30267-8
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32559419
UR  - https://www.sciencedirect.com/science/article/pii/S2213260020302678?via%3Dihub
UR  - http://hdl.handle.net/10044/1/80598
VL  - 8
ER  -

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Peter Openshaw - Professor of Experimental Medicine

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