Summary
Dr Periklis (Laki) Pantazis is a Reader in Advanced Optical Precision Imaging (equiv. Associate Professor) at the Department of Bioengineering at Imperial College London and the Director of the Imperial College London and LEICA Microsystems Imaging Hub, a strategic collaboration in the field of optical imaging and its uses in research and innovation between Imperial College London and Leica Microsystems.
He studied Biochemistry at the Leibniz University of Hannover, Hannover/Germany followed by a PhD in Biology and Bioengineering at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden./Germany.
He pursued then postdoctoral studies at the California Institute of Technology/Pasadena/CA/USA before joining as an Assistant Professor the ETH Zurich Department of Biosystems Science and Engineering in Basel/Switzerland.
In 2018/2019, he was appointed a Royal Society Wolfson Research Merit Award holder and established his Laboratory of Advanced Optical Precision Imaging at Imperial College London. The aim of his research activity is to develop advanced imaging technologies (nanoprobes (Sonay et al., ACS Nano 2021) (press release), imaging modality (Dempsey and Georgieva et al., Nat Meth 2015) (press release), and activity sensors (Yaganoglu and Kalyviotis et al., Nat Comm 2023) (press release) to establish an effective acquisition and interpretation workflow i) for the mechanistic analysis of biological systems in animal models such as mouse and zebrafish and ii) for the use in novel diagnostic and therapeutic strategies. His team fosters interdisciplinary projects in the fields of Developmental and Stem Cell Biology, Engineering, Chemistry and Optics and has secured 14 active/11 pending patents.
More information can be found on Pantazis’ Lab webpage.
Selected Publications
Journal Articles
Pantazis P, Pantazis P, Yaganoglu S, et al., 2023, Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi, Nature Communications, Vol:14, ISSN:2041-1723, Pages:1-16
Sonay AY, Kalyviotis K, Yaganoglu S, et al., 2021, Biodegradable harmonophores for targeted high-resolution in vivo tumor imaging, ACS Nano, Vol:15, ISSN:1936-0851, Pages:4144-4154
Welling M, Mohr MA, Ponti A, et al., 2019, Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins, Elife, Vol:8, ISSN:2050-084X, Pages:1-13
Sugiyama N, Sonay AY, Tussiwand R, et al., 2018, Effective Labeling of Primary Somatic Stem Cells with BaTiO3 Nanocrystals for Second Harmonic Generation Imaging, Small, Vol:14, ISSN:1613-6810, Pages:1-9
Mohr MA, Kobitski AY, Sabater LR, et al., 2017, Rational Engineering of Photoconvertible Fluorescent Proteins for Dual-Color Fluorescence Nanoscopy Enabled by a Triplet-State Mechanism of Primed Conversion, Angewandte Chemie - International Edition, Vol:56, ISSN:1433-7851, Pages:11628-11633
Zhang W, Lohman AW, Zhuravlova Y, et al., 2017, Optogenetic control with a photocleavable protein, PhoCl, Nature Methods, Vol:14, ISSN:1548-7091, Pages:391-394
Dempsey WP, Georgieva L, Helbling PM, et al., 2015, In vivo single-cell labeling by confined primed conversion, Nature Methods, Vol:12, ISSN:1548-7091, Pages:645-648
Pantazis P, Supatto W, 2014, Advances in whole-embryo imaging: a quantitative transition is underway, Nature Reviews Molecular Cell Biology, Vol:15, ISSN:1471-0072, Pages:327-339
Plachta N, Bollenbach T, Pease S, et al., 2011, Oct4 kinetics predict cell lineage patterning in the early mammalian embryo, Nature Cell Biology, Vol:13, ISSN:1465-7392, Pages:117-U24
Pantazis P, Maloney J, Wu D, et al., 2010, Second harmonic generating (SHG) nanoprobes for in vivo imaging, Proceedings of the National Academy of Sciences of the United States of America, Vol:107, ISSN:0027-8424, Pages:14535-14540
Kicheva A, Pantazis P, Bollenbach T, et al., 2007, Kinetics of morphogen gradient formation, Science, Vol:315, ISSN:0036-8075, Pages:521-525