Imperial College London
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Dr Periklis (Laki) Pantazis

Faculty of Engineering, Department of Bioengineering

Reader in Advanced Optical Precision Imaging
 
 
 
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Contact

 

+44 (0)20 7594 6367p.pantazis Website CV

 
 
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Location

 

3.14Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sonay:2021:10.1021/acsnano.0c10634,
author = {Sonay, AY and Kalyviotis, K and Yaganoglu, S and Unsal, A and Konantz, M and Teulon, C and Lieberwirth, I and Sieber, S and Jiang, S and Behzadi, S and Crespy, D and Landfester, K and Roke, S and Lengerke, C and Pantazis, P},
doi = {10.1021/acsnano.0c10634},
journal = {ACS Nano},
pages = {4144--4154},
title = {Biodegradable harmonophores for targeted high-resolution in vivo tumor imaging},
url = {http://dx.doi.org/10.1021/acsnano.0c10634},
volume = {15},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Optical imaging probes have played a major role in detecting and monitoring a variety of diseases. In particular, nonlinear optical imaging probes, such as second harmonic generating (SHG) nanoprobes, hold great promise as clinical contrast agents, as they can be imaged with little background signal and unmatched long-term photostability. As their chemical composition often includes transition metals, the use of inorganic SHG nanoprobes can raise long-term health concerns. Ideally, contrast agents for biomedical applications should be degraded in vivo without any long-term toxicological consequences to the organism. Here, we developed biodegradable harmonophores (bioharmonophores) that consist of polymer-encapsulated, self-assembling peptides that generate a strong SHG signal. When functionalized with tumor cell surface markers, these reporters can target single cancer cells with high detection sensitivity in zebrafish embryos in vivo. Thus, bioharmonophores will enable an innovative approach to cancer treatment using targeted high-resolution optical imaging for diagnostics and therapy.
AU  - Sonay,AY
AU  - Kalyviotis,K
AU  - Yaganoglu,S
AU  - Unsal,A
AU  - Konantz,M
AU  - Teulon,C
AU  - Lieberwirth,I
AU  - Sieber,S
AU  - Jiang,S
AU  - Behzadi,S
AU  - Crespy,D
AU  - Landfester,K
AU  - Roke,S
AU  - Lengerke,C
AU  - Pantazis,P
DO  - 10.1021/acsnano.0c10634
EP  - 4154
PY  - 2021///
SN  - 1936-0851
SP  - 4144
TI  - Biodegradable harmonophores for targeted high-resolution in vivo tumor imaging
T2  - ACS Nano
UR  - http://dx.doi.org/10.1021/acsnano.0c10634
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33630589
UR  - http://hdl.handle.net/10044/1/89794
VL  - 15
ER  -
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