Imperial College London

Dr Paolo Paredi MD, PhD

Faculty of MedicineNational Heart & Lung Institute

Clinical Research Fellow
 
 
 
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Contact

 

+44 (0)20 7351 8051p.paredi

 
 
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Location

 

Thoracic MedicineGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

62 results found

van de Kant KDG, Paredi P, Meah S, Kalsi HS, Barnes PJ, Usmani OSet al., 2015, The effect of body weight on distal airway function and airway inflammation, Obesity Research and Clinical Practice, Vol: 10, Pages: 564-573, ISSN: 1871-403X

Background/Objectives:Obesity is a global health problem that adversely influences the respiratory system. We assessed the effects of body mass index (BMI) on distal airway function and airway inflammation.Subjects/Methods:Impulse oscillometry (IOS) as a measure of distal airway function, together with spirometry, were assessed in adults with a range of different BMIs. Airway inflammation was assessed with the fraction of exhaled nitric oxide (FeNO) and participants exhaled at various exhalation flows to determine alveolar and bronchial NO.Results:In total 34 subjects were enrolled in the study; 19 subjects had a normal BMI (18.50–24.99), whilst 15 subjects were overweight (BMI 25.00–29.99), or obese (BMI ≥30). All subjects had normal spirometry. However, IOS measures of airway resistance (R) at 5 Hz, 20 Hz and frequency dependence (R5–20) were elevated in overweight/obese individuals, compared to subjects with a normal BMI (median (interquartile range)); 5 Hz: 0.41 (0.37, 0.45) vs. 0.32 (0.30, 0.37) kPa/l/s; 20 Hz: 0.34 (0.30, 0.37) vs. 0.30 (0.26, 0.33) kPa/l/s; R5–20: 0.06 (0.04, 0.11) vs. 0.03 (0.01, 0.05) kPa/l/s; p < 0.05), whereas airway reactance at 20 Hz was decreased in overweight/obese individuals (20 Hz: 0.07 (0.03, 0.09) vs. 0.10 (0.07, 0.13) kPa/l/s, p = 0.009; 5 Hz: −0.12 (−0.15, −0.10) vs. −0.10 (−0.13, −0.09) kPa/l/s, p = 0.07). In contrast, within-breath IOS measures (a sign of expiratory flow limitation) and FeNO inflammatory measures, did not differ between groups (p > 0.05).Conclusions: Being overweight has significant effects on distal and central airway function as determined by IOS, which is not detected by spirometry. Obesity does not influence airway inflammation as measured by FeNO. IOS is a reliable technique to identify airway abnormalities in the presence of normal spirometry in overweight people.

Journal article

Bikov A, Pride NB, Goldman MD, Hull JH, Horvath I, Barnes PJ, Usmani OS, Paredi Pet al., 2015, Glottal Aperture and Buccal Airflow Leaks Critically Affect Forced Oscillometry Measurements, CHEST, Vol: 148, Pages: 731-738, ISSN: 0012-3692

Journal article

Paredi P, Kharitonov SA, Meah S, Barnes PJ, Usmani OSet al., 2014, A Novel Approach to Partition Central and Peripheral Airway Nitric Oxide, CHEST, Vol: 145, Pages: 113-119, ISSN: 0012-3692

Journal article

Paredi, Kharitonov, Meah, Barnes, Usmaniet al., 2013, A novel approach to partition central and peripheral airway nitric oxide, Chest

Journal article

Bikov A, Paschalaki K, Logan-Sinclair R, Horvath I, Kharitonov SA, Barnes PJ, Usmani OS, Paredi Pet al., 2013, Standardised exhaled breath collection for the measurement of exhaled volatile organic compounds by proton transfer reaction mass spectrometry, BMC Pulmonary Medicine, Vol: 13, Pages: 1-7, ISSN: 1471-2466

BackgroundExhaled breath volatile organic compound (VOC) analysis for airway disease monitoring is promising. However, contrary to nitric oxide the method for exhaled breath collection has not yet been standardized and the effects of expiratory flow and breath-hold have not been sufficiently studied. These manoeuvres may also reveal the origin of exhaled compounds.Methods15 healthy volunteers (34 ± 7 years) participated in the study. Subjects inhaled through their nose and exhaled immediately at two different flows (5 L/min and 10 L/min) into methylated polyethylene bags. In addition, the effect of a 20 s breath-hold following inhalation to total lung capacity was studied. The samples were analyzed for ethanol and acetone levels immediately using proton-transfer-reaction mass-spectrometer (PTR-MS, Logan Research, UK).ResultsEthanol levels were negatively affected by expiratory flow rate (232.70 ± 33.50 ppb vs. 202.30 ± 27.28 ppb at 5 L/min and 10 L/min, respectively, p < 0.05), but remained unchanged following the breath hold (242.50 ± 34.53 vs. 237.90 ± 35.86 ppb, without and with breath hold, respectively, p = 0.11). On the contrary, acetone levels were increased following breath hold (1.50 ± 0.18 ppm) compared to the baseline levels (1.38 ± 0.15 ppm), but were not affected by expiratory flow (1.40 ± 0.14 ppm vs. 1.49 ± 0.14 ppm, 5 L/min vs. 10 L/min, respectively, p = 0.14). The diet had no significant effects on the gasses levels which showed good inter and intra session reproducibility.ConclusionsExhalation parameters such as expiratory flow and breath-hold may affect VOC levels significantly; therefore standardisation of exhaled VOC measurements is mandatory. Our preliminary results suggest a different origin in the respiratory tr

Journal article

Paredi P, Barnes PJ, 2013, A breath of hot air?, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 17, Pages: 855-855, ISSN: 1027-3719

Journal article

Caramori G, Paredi P, 2013, Global Lung Function Standardisation: Finally Making Our Dream a Reality?, RESPIRATION, Vol: 86, Pages: 179-180, ISSN: 0025-7931

Journal article

Hurt K, Paredi P, Kalsi H, Hodson M, Usmani O, Bilton Det al., 2011, WHOLE BREATH AND INSPIRATORY - EXPIRATORY ANALYSIS OF REACTANCE AT 5HZ IN ADULT CYSTIC FIBROSIS, PEDIATRIC PULMONOLOGY, Pages: 345-345, ISSN: 8755-6863

Journal article

Paredi P, Paschalaki K, 2011, Exhaled Nitric Oxide, Technical Considerations, Non-Invasive assessment of airways inflammation in asthma and COPD, Editors: Loukides, Kostikas, Barnes, Athens, Publisher: Paschalidis Medical Pubblications, Pages: 23-37, ISBN: 9789604891047

Book chapter

Paredi P, Paschalaki K, 2011, Other Exhaled Biomarkers, Non-invasive assessment of airway inflammation in asthma and COPD, Editors: Loukides, Kostikas, Barnes, Athens, Publisher: Paschalidis Medical Pubblications, Pages: 261-279

Book chapter

Paredi P, Usmani OS, Kharitonov SA, Siafakas NM, Pride NB, Barnes PJet al., 2010, In memoriam Michael Goldman (1936-2010), EUROPEAN RESPIRATORY JOURNAL, Vol: 36, Pages: 977-978, ISSN: 0903-1936

Journal article

Carbone R, Bottino G, Paredi P, Shah P, Meyer KCet al., 2010, Predictors of survival in idiopathic interstitial pneumonia, EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, Vol: 14, Pages: 695-704, ISSN: 1128-3602

Journal article

Paredi P, Goldman M, Alamen A, Ausin P, Usmani OS, Pride NB, Barnes PJet al., 2010, Comparison of inspiratory and expiratory resistance and reactance in patients with asthma and chronic obstructive pulmonary disease, THORAX, Vol: 65, Pages: 263-267, ISSN: 0040-6376

Journal article

Carbone RG, Balbi M, Paredi P, Veronese Met al., 2010, PROGNOSTIC SIGNIFICANCE OF BRAIN NATRIURETIC PEPTIDE IN IDIOPATIC PULMONARY FIBROSIS, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 181, ISSN: 1073-449X

Journal article

Paredi P, Barnes PJ, 2009, The airway vasculature: recent advances and clinical implications, THORAX, Vol: 64, Pages: 444-450, ISSN: 0040-6376

Journal article

Paredi P, Goldman M, Pride NP, Usmani OS, Alamen A, Barnes PJet al., 2009, Greater Reactance with Abnormal Small Airway Compliance Measured by Impulse Oscillometry in COPD Compared to Asthmatic Patients., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X

Journal article

Paredi P, Ward S, Cramer D, Barnes PJ, Kharitonov SAet al., 2007, Normal bronchial blood flow in COPD is unaffected by inhaled corticosteroids and correlates with exhaled nitric oxide, CHEST, Vol: 131, Pages: 1075-1081, ISSN: 0012-3692

Journal article

Paredi P, 2007, How much smoke do we need in order to assume that there is a fire?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 175, Pages: 629-629, ISSN: 1073-449X

Journal article

Invernizzi G, Ruprecht A, De Marco C, Paredi P, Boffi Ret al., 2007, Residual tobacco smoke: measurement of its washout time in the lung and of its contribution to environmental tobacco smoke, TOBACCO CONTROL, Vol: 16, Pages: 29-33, ISSN: 0964-4563

Journal article

Invernizzi G, Boffi R, Ruprecht AA, Barnes PJ, Kharitonov SA, Paredi Pet al., 2006, Real-time measurement of particulate matter deposition in the lung, BIOMARKERS, Vol: 11, Pages: 221-232, ISSN: 1354-750X

Journal article

Paredi P, Kharitonov SA, Barnes PJ, 2005, Correlation of exhaled breath temperature with bronchial blood flow in asthma, RESPIRATORY RESEARCH, Vol: 6

Journal article

Paredi P, Kharitonov SA, Barnes PJ, 2003, Exhaled breath temperature in airways disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 22, Pages: 394-395, ISSN: 0903-1936

Journal article

Paredi P, Caramori G, Cramer D, Ward S, Ciaccia A, Papi A, Kharitonov SA, Barnes PJet al., 2003, Slower rise of exhaled breath temperature, in chronic obstructive pulmonary disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 21, Pages: 439-443, ISSN: 0903-1936

Journal article

Paredi P, Kharitonov SA, Barnes PJ, 2003, Exhaled carbon monoxide in lung disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 21, Pages: 197-197, ISSN: 0903-1936

Journal article

Paredi P, Kharitonov SA, Barnes PJ, 2003, Exhaled breath temperature in asthma., Eur Respir J, Vol: 21, ISSN: 0903-1936

Journal article

Paredi P, Kharitonov SA, Barnes PJ, 2003, Exhaled carbon monoxide in lung disease., Eur Respir J, Vol: 21, ISSN: 0903-1936

Journal article

Paredi P, Kharitonov SA, Barnes PJ, 2003, Exhaled breath temperature in asthma, ERJ, Vol: 21, Pages: 195-196

Journal article

Paredi P, Kharitonov SA, Barnes PJ, 2003, Exhaled carbon monoxide in lung disease, ERJ, Vol: 21, Pages: 197-198

Journal article

Paredi P, Kharitonov SA, Barnes PJ, 2003, Reduced exhaled breath temperature in COPD, ERJ, Vol: 21, Pages: 439-443

Journal article

Invernizzi G, Ruprecht A, Mazza R, Majno E, Rossetti E, Paredi P, Boffi Ret al., 2002, Real-time measurement of indoor particulate matter originating from environmental tobacco smoke: a pilot study, Epidemiol Prev, Vol: 26, Pages: 30-34

Journal article

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