Publications
62 results found
van de Kant KDG, Paredi P, Meah S, et al., 2015, The effect of body weight on distal airway function and airway inflammation, Obesity Research and Clinical Practice, Vol: 10, Pages: 564-573, ISSN: 1871-403X
Background/Objectives:Obesity is a global health problem that adversely influences the respiratory system. We assessed the effects of body mass index (BMI) on distal airway function and airway inflammation.Subjects/Methods:Impulse oscillometry (IOS) as a measure of distal airway function, together with spirometry, were assessed in adults with a range of different BMIs. Airway inflammation was assessed with the fraction of exhaled nitric oxide (FeNO) and participants exhaled at various exhalation flows to determine alveolar and bronchial NO.Results:In total 34 subjects were enrolled in the study; 19 subjects had a normal BMI (18.50–24.99), whilst 15 subjects were overweight (BMI 25.00–29.99), or obese (BMI ≥30). All subjects had normal spirometry. However, IOS measures of airway resistance (R) at 5 Hz, 20 Hz and frequency dependence (R5–20) were elevated in overweight/obese individuals, compared to subjects with a normal BMI (median (interquartile range)); 5 Hz: 0.41 (0.37, 0.45) vs. 0.32 (0.30, 0.37) kPa/l/s; 20 Hz: 0.34 (0.30, 0.37) vs. 0.30 (0.26, 0.33) kPa/l/s; R5–20: 0.06 (0.04, 0.11) vs. 0.03 (0.01, 0.05) kPa/l/s; p < 0.05), whereas airway reactance at 20 Hz was decreased in overweight/obese individuals (20 Hz: 0.07 (0.03, 0.09) vs. 0.10 (0.07, 0.13) kPa/l/s, p = 0.009; 5 Hz: −0.12 (−0.15, −0.10) vs. −0.10 (−0.13, −0.09) kPa/l/s, p = 0.07). In contrast, within-breath IOS measures (a sign of expiratory flow limitation) and FeNO inflammatory measures, did not differ between groups (p > 0.05).Conclusions: Being overweight has significant effects on distal and central airway function as determined by IOS, which is not detected by spirometry. Obesity does not influence airway inflammation as measured by FeNO. IOS is a reliable technique to identify airway abnormalities in the presence of normal spirometry in overweight people.
Bikov A, Pride NB, Goldman MD, et al., 2015, Glottal Aperture and Buccal Airflow Leaks Critically Affect Forced Oscillometry Measurements, CHEST, Vol: 148, Pages: 731-738, ISSN: 0012-3692
Paredi P, Kharitonov SA, Meah S, et al., 2014, A Novel Approach to Partition Central and Peripheral Airway Nitric Oxide, CHEST, Vol: 145, Pages: 113-119, ISSN: 0012-3692
Paredi, Kharitonov, Meah, et al., 2013, A novel approach to partition central and peripheral airway nitric oxide, Chest
Bikov A, Paschalaki K, Logan-Sinclair R, et al., 2013, Standardised exhaled breath collection for the measurement of exhaled volatile organic compounds by proton transfer reaction mass spectrometry, BMC Pulmonary Medicine, Vol: 13, Pages: 1-7, ISSN: 1471-2466
BackgroundExhaled breath volatile organic compound (VOC) analysis for airway disease monitoring is promising. However, contrary to nitric oxide the method for exhaled breath collection has not yet been standardized and the effects of expiratory flow and breath-hold have not been sufficiently studied. These manoeuvres may also reveal the origin of exhaled compounds.Methods15 healthy volunteers (34 ± 7 years) participated in the study. Subjects inhaled through their nose and exhaled immediately at two different flows (5 L/min and 10 L/min) into methylated polyethylene bags. In addition, the effect of a 20 s breath-hold following inhalation to total lung capacity was studied. The samples were analyzed for ethanol and acetone levels immediately using proton-transfer-reaction mass-spectrometer (PTR-MS, Logan Research, UK).ResultsEthanol levels were negatively affected by expiratory flow rate (232.70 ± 33.50 ppb vs. 202.30 ± 27.28 ppb at 5 L/min and 10 L/min, respectively, p < 0.05), but remained unchanged following the breath hold (242.50 ± 34.53 vs. 237.90 ± 35.86 ppb, without and with breath hold, respectively, p = 0.11). On the contrary, acetone levels were increased following breath hold (1.50 ± 0.18 ppm) compared to the baseline levels (1.38 ± 0.15 ppm), but were not affected by expiratory flow (1.40 ± 0.14 ppm vs. 1.49 ± 0.14 ppm, 5 L/min vs. 10 L/min, respectively, p = 0.14). The diet had no significant effects on the gasses levels which showed good inter and intra session reproducibility.ConclusionsExhalation parameters such as expiratory flow and breath-hold may affect VOC levels significantly; therefore standardisation of exhaled VOC measurements is mandatory. Our preliminary results suggest a different origin in the respiratory tr
Paredi P, Barnes PJ, 2013, A breath of hot air?, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 17, Pages: 855-855, ISSN: 1027-3719
- Author Web Link
- Cite
- Citations: 1
Caramori G, Paredi P, 2013, Global Lung Function Standardisation: Finally Making Our Dream a Reality?, RESPIRATION, Vol: 86, Pages: 179-180, ISSN: 0025-7931
- Author Web Link
- Cite
- Citations: 1
Hurt K, Paredi P, Kalsi H, et al., 2011, WHOLE BREATH AND INSPIRATORY - EXPIRATORY ANALYSIS OF REACTANCE AT 5HZ IN ADULT CYSTIC FIBROSIS, PEDIATRIC PULMONOLOGY, Pages: 345-345, ISSN: 8755-6863
Paredi P, Paschalaki K, 2011, Exhaled Nitric Oxide, Technical Considerations, Non-Invasive assessment of airways inflammation in asthma and COPD, Editors: Loukides, Kostikas, Barnes, Athens, Publisher: Paschalidis Medical Pubblications, Pages: 23-37, ISBN: 9789604891047
Paredi P, Paschalaki K, 2011, Other Exhaled Biomarkers, Non-invasive assessment of airway inflammation in asthma and COPD, Editors: Loukides, Kostikas, Barnes, Athens, Publisher: Paschalidis Medical Pubblications, Pages: 261-279
Paredi P, Usmani OS, Kharitonov SA, et al., 2010, In memoriam Michael Goldman (1936-2010), EUROPEAN RESPIRATORY JOURNAL, Vol: 36, Pages: 977-978, ISSN: 0903-1936
Carbone R, Bottino G, Paredi P, et al., 2010, Predictors of survival in idiopathic interstitial pneumonia, EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, Vol: 14, Pages: 695-704, ISSN: 1128-3602
- Author Web Link
- Cite
- Citations: 4
Paredi P, Goldman M, Alamen A, et al., 2010, Comparison of inspiratory and expiratory resistance and reactance in patients with asthma and chronic obstructive pulmonary disease, THORAX, Vol: 65, Pages: 263-267, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 102
Carbone RG, Balbi M, Paredi P, et al., 2010, PROGNOSTIC SIGNIFICANCE OF BRAIN NATRIURETIC PEPTIDE IN IDIOPATIC PULMONARY FIBROSIS, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 181, ISSN: 1073-449X
Paredi P, Barnes PJ, 2009, The airway vasculature: recent advances and clinical implications, THORAX, Vol: 64, Pages: 444-450, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 59
Paredi P, Goldman M, Pride NP, et al., 2009, Greater Reactance with Abnormal Small Airway Compliance Measured by Impulse Oscillometry in COPD Compared to Asthmatic Patients., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
Paredi P, Ward S, Cramer D, et al., 2007, Normal bronchial blood flow in COPD is unaffected by inhaled corticosteroids and correlates with exhaled nitric oxide, CHEST, Vol: 131, Pages: 1075-1081, ISSN: 0012-3692
- Author Web Link
- Cite
- Citations: 17
Paredi P, 2007, How much smoke do we need in order to assume that there is a fire?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 175, Pages: 629-629, ISSN: 1073-449X
Invernizzi G, Ruprecht A, De Marco C, et al., 2007, Residual tobacco smoke: measurement of its washout time in the lung and of its contribution to environmental tobacco smoke, TOBACCO CONTROL, Vol: 16, Pages: 29-33, ISSN: 0964-4563
- Author Web Link
- Cite
- Citations: 34
Invernizzi G, Boffi R, Ruprecht AA, et al., 2006, Real-time measurement of particulate matter deposition in the lung, BIOMARKERS, Vol: 11, Pages: 221-232, ISSN: 1354-750X
- Author Web Link
- Cite
- Citations: 14
Paredi P, Kharitonov SA, Barnes PJ, 2005, Correlation of exhaled breath temperature with bronchial blood flow in asthma, RESPIRATORY RESEARCH, Vol: 6
- Author Web Link
- Cite
- Citations: 71
Paredi P, Kharitonov SA, Barnes PJ, 2003, Exhaled breath temperature in airways disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 22, Pages: 394-395, ISSN: 0903-1936
- Author Web Link
- Cite
- Citations: 2
Paredi P, Caramori G, Cramer D, et al., 2003, Slower rise of exhaled breath temperature, in chronic obstructive pulmonary disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 21, Pages: 439-443, ISSN: 0903-1936
- Author Web Link
- Cite
- Citations: 21
Paredi P, Kharitonov SA, Barnes PJ, 2003, Exhaled carbon monoxide in lung disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 21, Pages: 197-197, ISSN: 0903-1936
- Author Web Link
- Cite
- Citations: 4
Paredi P, Kharitonov SA, Barnes PJ, 2003, Exhaled breath temperature in asthma., Eur Respir J, Vol: 21, ISSN: 0903-1936
Paredi P, Kharitonov SA, Barnes PJ, 2003, Exhaled carbon monoxide in lung disease., Eur Respir J, Vol: 21, ISSN: 0903-1936
Paredi P, Kharitonov SA, Barnes PJ, 2003, Exhaled breath temperature in asthma, ERJ, Vol: 21, Pages: 195-196
Paredi P, Kharitonov SA, Barnes PJ, 2003, Exhaled carbon monoxide in lung disease, ERJ, Vol: 21, Pages: 197-198
Paredi P, Kharitonov SA, Barnes PJ, 2003, Reduced exhaled breath temperature in COPD, ERJ, Vol: 21, Pages: 439-443
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.