Imperial College London
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Professor Philip J. Parsons

Faculty of Natural Sciences, Department of Chemistry

Senior Research Investigator
 
 
 
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Contact

 

p.parsons

 
 
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Location

 

110EMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Almond-Thynne:2018:10.1021/acs.joc.8b00794,
author = {Almond-Thynne, J and Han, J and White, AJP and Polyzos, A and Parsons, PJ and Barrett, AGM},
doi = {10.1021/acs.joc.8b00794},
journal = {Journal of Organic Chemistry},
pages = {6783--6787},
title = {Bidirectional synthesis of di-t-butyl (2S,6S,8S)- and (2R,6R,8R)-1,7-diazaspiro[5.5]undecane-2,8-dicarboxylate and related spirodiamines},
url = {http://dx.doi.org/10.1021/acs.joc.8b00794},
volume = {83},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Efficient syntheses of both enantiomers of a spirodiamine diester from (L)- and (D)-aspartic acid are described. The key transformation was the conversion of Boc-protected t-butyl aspartate into the derived aldehyde, two directional Horner Emmons olefination, hydrogenation and selective acid-catalyzed Boc-deprotection and spirocyclization. An alternative, two-directional approaches to derivatives of 1,7-diazaspiro[5.5]undecane is described.
AU  - Almond-Thynne,J
AU  - Han,J
AU  - White,AJP
AU  - Polyzos,A
AU  - Parsons,PJ
AU  - Barrett,AGM
DO  - 10.1021/acs.joc.8b00794
EP  - 6787
PY  - 2018///
SN  - 0022-3263
SP  - 6783
TI  - Bidirectional synthesis of di-t-butyl (2S,6S,8S)- and (2R,6R,8R)-1,7-diazaspiro[5.5]undecane-2,8-dicarboxylate and related spirodiamines
T2  - Journal of Organic Chemistry
UR  - http://dx.doi.org/10.1021/acs.joc.8b00794
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29792022
UR  - http://hdl.handle.net/10044/1/60330
VL  - 83
ER  -
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