Imperial College London
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Professor Philip J. Parsons

Faculty of Natural Sciences, Department of Chemistry

Senior Research Investigator
 
 
 
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Contact

 

p.parsons

 
 
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Location

 

110EMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Natho:2019:10.1021/acs.joc.9b01290,
author = {Natho, P and Allen, LAT and White, AJP and Parsons, PJ},
doi = {10.1021/acs.joc.9b01290},
journal = {The Journal of Organic Chemistry},
pages = {9611--9626},
title = {A transition-metal-free access to heteroaromatic-fused 4-tetralones by the oxidative ring expansion of the cyclobutanol moiety},
url = {http://dx.doi.org/10.1021/acs.joc.9b01290},
volume = {84},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Advances in the transition-metal-free cyclobutanol ring expansion to 4-tetralones under N-bromosuccinimide mediation are described. We have expanded the scope of this ring expansion methodology and investigated the effect substituents on the aromatic ring, and the cyclobutanol moiety, have on the outcome of the reaction. Limitations with certain substituents on the cyclobutanol moiety are also described. Further experimental evidence to support our mechanistic understanding is disclosed, and we now preclude the suggested involvement of a primary radical for this transformation.
AU  - Natho,P
AU  - Allen,LAT
AU  - White,AJP
AU  - Parsons,PJ
DO  - 10.1021/acs.joc.9b01290
EP  - 9626
PY  - 2019///
SN  - 0022-3263
SP  - 9611
TI  - A transition-metal-free access to heteroaromatic-fused 4-tetralones by the oxidative ring expansion of the cyclobutanol moiety
T2  - The Journal of Organic Chemistry
UR  - http://dx.doi.org/10.1021/acs.joc.9b01290
UR  - https://pubs.acs.org/doi/10.1021/acs.joc.9b01290
UR  - http://hdl.handle.net/10044/1/71782
VL  - 84
ER  -
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