Imperial College London
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Professor Philip J. Parsons

Faculty of Natural Sciences, Department of Chemistry

Senior Research Investigator
 
 
 
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Contact

 

p.parsons

 
 
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Location

 

110EMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mies:2021:10.1021/acs.joc.0c02638,
author = {Mies, T and White, AJP and Parsons, PJ and Barrett, AGM},
doi = {10.1021/acs.joc.0c02638},
journal = {Journal of Organic Chemistry},
pages = {1802--1817},
title = {Biomimetic syntheses of analogs of hongoquercin A and B by late-stage derivatization},
url = {http://dx.doi.org/10.1021/acs.joc.0c02638},
volume = {86},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The hongoquercins are tetracyclic meroterpenoid natural products with the trans–transoid decalin-dihydrobenzopyran ring system, which display a range of different bioactivities. In this study, the syntheses of a range of hongoquercins using gold-catalyzed enyne cyclization reactions and further derivatization are described. The parent enyne resorcylate precursors were synthesized biomimetically from the corresponding dioxinone keto ester via regioselective acylation, Tsuji-Trost allylic decarboxylative rearrangement, and aromatization. The dioxinone keto ester 12 was prepared in 6 steps from geraniol using allylic functionalization and alkyne synthesis.
AU  - Mies,T
AU  - White,AJP
AU  - Parsons,PJ
AU  - Barrett,AGM
DO  - 10.1021/acs.joc.0c02638
EP  - 1817
PY  - 2021///
SN  - 0022-3263
SP  - 1802
TI  - Biomimetic syntheses of analogs of hongoquercin A and B by late-stage derivatization
T2  - Journal of Organic Chemistry
UR  - http://dx.doi.org/10.1021/acs.joc.0c02638
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000643595200043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.acs.org/doi/10.1021/acs.joc.0c02638
UR  - http://hdl.handle.net/10044/1/90523
VL  - 86
ER  -
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