Imperial College London
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Professor Philip J. Parsons

Faculty of Natural Sciences, Department of Chemistry

Senior Research Investigator
 
 
 
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Contact

 

p.parsons

 
 
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Location

 

110EMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Folgueiras-Amador:2022:10.1002/anie.202203694,
author = {Folgueiras-Amador, AA and Teuten, AE and Salam-Perez, M and Pearce, JE and Denuault, G and Pletcher, D and Parsons, PJ and Harrowven, DC and Brown, RCD},
doi = {10.1002/anie.202203694},
journal = {Angewandte Chemie International Edition},
title = {Cathodic radical cyclisation of aryl halides using a strongly-reducing catalytic mediator in flow},
url = {http://dx.doi.org/10.1002/anie.202203694},
volume = {61},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Electro-reductive radical cyclisation of aryl halides affords the corresponding hetero- and carbo-cycles in an undivided flow reactor equipped with steel and carbon electrodes using an organic mediator. A dissolving metal anode is not needed, and the mediator can be employed in a sub-stoichiometric amount (0.05equiv), increasing the practical utility of cathodic radical cyclisation. The methodology is applied to O-, N-, and C-tethers, yielding tricyclic fused and spiro systems. In the absence of mediator, the major pathway is hydrogenolysis of the C−X bond, a 2 e− process occurring at the cathode. Predominance of the radical pathway in presence of a strongly reducing mediator (M) is consistent with homogeneous electron-transfer in a reaction layer detached from the cathode surface, where the flux of M.− leaving the electrode is such that little aryl halide reaches the cathode.
AU  - Folgueiras-Amador,AA
AU  - Teuten,AE
AU  - Salam-Perez,M
AU  - Pearce,JE
AU  - Denuault,G
AU  - Pletcher,D
AU  - Parsons,PJ
AU  - Harrowven,DC
AU  - Brown,RCD
DO  - 10.1002/anie.202203694
PY  - 2022///
SN  - 1433-7851
TI  - Cathodic radical cyclisation of aryl halides using a strongly-reducing catalytic mediator in flow
T2  - Angewandte Chemie International Edition
UR  - http://dx.doi.org/10.1002/anie.202203694
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000826548500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1002/anie.202203694
UR  - http://hdl.handle.net/10044/1/98509
VL  - 61
ER  -
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