Imperial College London
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Professor Philip J. Parsons

Faculty of Natural Sciences, Department of Chemistry

Senior Research Investigator
 
 
 
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Contact

 

p.parsons

 
 
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Location

 

110EMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Almond-Thynne:2017:10.1021/acsomega.7b00482,
author = {Almond-Thynne, J and White, AJP and Polyzos, A and Rzepa, H and Parsons, P and Barrett, AGM},
doi = {10.1021/acsomega.7b00482},
journal = {ACS Omega},
pages = {3241--3249},
title = {Synthesis and reactions of benzannulated spiroaminals: tetrahydrospirobiquinolines},
url = {http://dx.doi.org/10.1021/acsomega.7b00482},
volume = {2},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - An efficient two-step synthesis of symmetrical and unsymmetrical tetrahydrospirobiquinolines from o-azidobenzaldehydes is reported. A novel series of tetrahydrospirobiquinolines was prepared by sequential double-aldol condensation with acetone, cyclopentanone, and cyclohexanone to form the corresponding o,o′-diazido-dibenzylidene-acetone, -cyclopentanone, and -cyclohexanone derivatives, respectively, and hydrogenation–spirocyclization. The spirodiamines were further derivatized by electrophilic aromatic bromination, Suzuki coupling, and N-alkylation, all of which proceeded with preservation of the spirocyclic core.
AU  - Almond-Thynne,J
AU  - White,AJP
AU  - Polyzos,A
AU  - Rzepa,H
AU  - Parsons,P
AU  - Barrett,AGM
DO  - 10.1021/acsomega.7b00482
EP  - 3249
PY  - 2017///
SN  - 2470-1343
SP  - 3241
TI  - Synthesis and reactions of benzannulated spiroaminals: tetrahydrospirobiquinolines
T2  - ACS Omega
UR  - http://dx.doi.org/10.1021/acsomega.7b00482
UR  - http://hdl.handle.net/10044/1/48747
VL  - 2
ER  -
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