Imperial College London
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DrPablo NoelPerez Guzman

Faculty of Medicine, School of Public Health

Research Postgraduate
 
 
 
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Contact

 

p.perez-guzman Website

 
 
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Location

 

G31Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Davis:2021:10.1186/s12916-021-01978-7,
author = {Davis, K and Perez, Guzman P and Hoyer, A and Brinks, R and Gregg, E and Althoff, KN and Justice, AC and Reiss, P and Gregson, S and Smit, M},
doi = {10.1186/s12916-021-01978-7},
journal = {BMC Medicine},
title = {Association between HIV infection and hypertension: a global systematic review and meta-analysis of cross-sectional studies},
url = {http://dx.doi.org/10.1186/s12916-021-01978-7},
volume = {19},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:Improved access to effective antiretroviral therapy has meant that people living with HIV (PLHIV) are surviving to older ages. However, PLHIV may be ageing differently to HIV-negative individuals, with dissimilar burdens of non-communicable diseases, such as hypertension. While some observational studies have reported a higher risk of prevalent hypertension among PLHIV compared to HIV-negative individuals, others have found a reduced burden. To clarify the relationship between HIV and hypertension, we identified observational studies and pooled their results to assess whether there is a difference in hypertension risk by HIV status.Methods:We performed a global systematic review and meta-analysis of published cross-sectional studies that examined hypertension risk by HIV status among adults aged > 15 (PROSPERO: CRD42019151359). We searched MEDLINE, EMBASE, Global Health and Cochrane CENTRAL to August 23, 2020, and checked reference lists of included articles. Our main outcome was the risk ratio for prevalent hypertension in PLHIV compared to HIV-negative individuals. Summary estimates were pooled with a random effects model and meta-regression explored whether any difference was associated with study-level factors.Results:Of 21,527 identified studies, 59 were eligible (11,101,581 participants). Crude global hypertension risk was lower among PLHIV than HIV-negative individuals (risk ratio 0.90, 95% CI 0.85–0.96), although heterogeneity between studies was high (I2 = 97%, p < 0.0001). The relationship varied by continent, with risk higher among PLHIV in North America (1.12, 1.02–1.23) and lower among PLHIV in Africa (0.75, 0.68–0.83) and Asia (0.77, 0.63–0.95). Meta-regression revealed strong evidence of a difference in risk ratios when comparing North American and European studies to African ones (North America 1.45, 1.21–1.74; Europe 1.20, 1.03–1.40).Conclusions:Our findings suggest that the r
AU  - Davis,K
AU  - Perez,Guzman P
AU  - Hoyer,A
AU  - Brinks,R
AU  - Gregg,E
AU  - Althoff,KN
AU  - Justice,AC
AU  - Reiss,P
AU  - Gregson,S
AU  - Smit,M
DO  - 10.1186/s12916-021-01978-7
PY  - 2021///
SN  - 1741-7015
TI  - Association between HIV infection and hypertension: a global systematic review and meta-analysis of cross-sectional studies
T2  - BMC Medicine
UR  - http://dx.doi.org/10.1186/s12916-021-01978-7
UR  - http://hdl.handle.net/10044/1/89236
VL  - 19
ER  -
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