Publications
296 results found
Afoke J, Punjabi PP, 2017, Certainty, in a time of uncertainty: The science of Paradox, PERFUSION-UK, Vol: 32, Pages: 3-3, ISSN: 0267-6591
Sarvananthan S, Lewis FC, Gritti G, et al., 2016, The Distribution and Characteristics of Endogenous Cardiac Stem Cells in All Four Chambers of the Adult Human Heart, Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
Bello SO, Singh C, Jayakumar S, et al., 2016, Role of Cardiomyocyte Regeneration in Mechanical Unloading Induced Reverse Cardiac Remodeling, Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
Petrone G, Theodoropoulos P, Punjabi PP, 2016, Early Results of Rheumatic Mitral Valve Repair., J Heart Valve Dis, Vol: 25, Pages: 691-695, ISSN: 0966-8519
BACKGROUND AND AIM OF THE STUDY: Mitral valve repair (MVr) in rheumatic heart disease (RHD) remains challenging. The present authors' surgical experience of MVr in 56 patients with RHD operated in between January 2011 and September 2014 is reported. METHODS: Among the patients (mean age 32 ± 11 years), 11 were in NYHA functional class II, 32 in class III, and seven in class IV. An adequate or oversized autologous pericardial patch was sutured to extend the coaptating edge of both the anterior leaflet (in 18 patients) and the posterior leaflet (in 30 patients). Neochordae were implanted as needed (n = 43), and leaflet thinning (n = 13), commissurotomy (n = 15) and chordal splitting (n = 9) were also performed. A rigid annuloplasty ring was implanted in 32 patients, and in 24 patients a complete flexible annuloplasty ring made from pericardium, 4 mm Gore-Tex tube graft or a Dacron patch was constructed. Repair was not attempted in 16 patients, with replacement using a mechanical bileaflet prosthesis being considered the only option. RESULTS: Intraoperative post-repair transesophageal echocardiography demonstrated competency, with trivial mitral regurgitation (MR) up to grade I in all patients and a minimum coaptation depth ≥5 mm. There were no intraoperative or in-hospital deaths. Clinical and echocardiographic evaluations were performed up to six weeks after surgery, at which time 51 patients were in NYHA classes I-II and five were in class III. Residual mild MR up to grade I was identified in six patients. No recurrence of MR was observed in any of the patients, and no patients were reoperated on. CONCLUSIONS: The lack of adequate access to anticoagulation medication and monitoring, in addition to religious/cultural bias to the type of prosthetic valve used in low-income countries, necessitates an increase in the numbers of rheumatic MVr.
Punjabi PP, 2016, Back to the Future: surgery and percutaneous devices, PERFUSION-UK, Vol: 31, Pages: 624-624, ISSN: 0267-6591
Tan MKH, Jarral OA, Thong EHE, et al., 2016, Quality of life after mitral valve intervention, Interactive Cardiovascular and Thoracic Surgery, Vol: 24, Pages: 265-272, ISSN: 1569-9293
Advancements in surgical technique and understanding of the pathophysiology of mitral valve (MV) dysfunction have led to improved outcomes. Seen as a development beyond measures of morbidity and mortality, health-related quality-of-life (HRQOL) outcome measures are becoming increasingly popular. These measures are important because complications following routine (i.e. low-risk) operations on the MV are uncommon and further markers of outcome are needed. Surgeons are increasingly operating earlier on asymptomatic patients and will need to prove that HRQOL is not impacted. Novel minimally invasive and transcatheter technologies will also need to demonstrate satisfactory HRQOL outcomes prior to widespread use. This systematic review provides an overview of all available literature detailing HRQOL in patients receiving MV interventions. In the 43 studies included, 6865 patients underwent procedures ranging from open replacement to percutaneous repair using devices such as the Mitraclip Clip Delivery System (MitraClip) (Abbott Vascular, Santa Clara, CA, USA). Most studies performed baseline HRQOL assessment, allowing postinterventional comparison. While the underlying literature had deficiencies, most studies report acceptable postintervention HRQOL that was comparable to that of matched general populations. Patient-specific (e.g. female gender, renal dysfunction) and surgical-specific factors (e.g. replacement instead of repair, elevated transmitral gradient) were identified that predispose patients to poorer long-term HRQOL outcomes. These factors are important for clinicians developing strategies to maximize their HRQOL outcomes. Future randomized studies would benefit from HRQOL measurements at specific time points to allow large-scale comparisons. Establishing a common HRQOL instrument for use in MV intervention studies may support detailed comparisons between specific techniques. Physical activity monitors, physiological biomarkers and radiological markers could a
Ahmad Y, Punjabi PP, 2016, Book Review: Textbook of Interventional Cardiology by Eric J Topol, Paul S Teirstein., Perfusion, Vol: 31, Pages: 619-619
Eisen A, Bhatt DL, Steg PG, et al., 2016, Angina and Future Cardiovascular Events in Stable Patients With Coronary Artery Disease: Insights From the Reduction of Atherothrombosis for Continued Health (REACH) Registry, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 5, ISSN: 2047-9980
Shah SH, Punjabi PP, 2016, Book Review: Clinical Lipidology. A Companion to Braunwald's Heart Disease by Christie M. Ballantyne., Perfusion, Vol: 31
Sanchez-Alonso JL, Bhargava A, O'Hara T, et al., 2016, Microdomain-specific modulation of L-type calcium channels leads to triggered ventricular arrhythmia in heart failure, Circulation Research, Vol: 119, Pages: 944-955, ISSN: 1524-4571
RATIONALE: Disruption in subcellular targeting of Ca(2+) signaling complexes secondary to changes in cardiac myocyte structure may contribute to the pathophysiology of a variety of cardiac diseases, including heart failure (HF) and certain arrhythmias. OBJECTIVE: To explore microdomain-targeted remodeling of ventricular L-type Ca(2+) channels (LTCCs) in HF. METHODS AND RESULTS: Super-resolution scanning patch-clamp, confocal and fluorescence microscopy were used to explore distribution of single LTCCs in different membrane microdomains of non-failing and failing human and rat ventricular myocytes. Disruption of membrane structure in both species led to re-distribution of functional LTCCs from their canonical location in transversal tubules (T-tubules) to the non-native crest of the sarcolemma, where their open probability (Po) was dramatically increased (0.034±0.011 vs 0.154±0.027, P<0.001). High Po was linked to enhanced calcium-calmodulin kinase II (CaMKII)-mediated phosphorylation in non-native microdomains and resulted in an elevated ICa,L window current which contributed to the development of early afterdepolarizations (EADs). A novel model of LTCC function in HF was developed; following its validation with experimental data, the model was used to ascertain how HF-induced T-tubule loss led to altered LTCC function and EADs. The HF myocyte model was then implemented in a 3D left ventricle model, demonstrating that such EADs can propagate and initiate reentrant arrhythmias. CONCLUSIONS: Microdomain-targeted remodeling of LTCC properties is an important event in pathways that may contribute to ventricular arrhythmogenesis in the settings of HF-associated remodeling. This extends beyond the classical concept of electrical remodelling in HF and adds a new dimension to cardiovascular disease.
Soylu E, Harling L, Ashrafian H, et al., 2016, A systematic review of the safety and efficacy of distal coronary artery anastomotic devices in MIDCAB and TECAB surgery., Perfusion, Vol: 31, Pages: 537-543, ISSN: 0267-6591
BACKGROUND: Minimally invasive direct coronary artery bypass (MIDCAB) and totally endoscopic coronary artery bypass (TECAB) techniques may improve recovery and reduce hospital stay following coronary artery bypass surgery (CABG). However, working in a limited space with indirect visualisation would greatly benefit from a simple, high-quality and reproducible automated distal anastomotic method. Several devices have been developed; however, their uptake has been limited due to uncertainty around their impact on patient outcomes. METHODS: A systematic review of the literature identified six studies, incorporating 139 subjects undergoing MIDCAB or TECAB surgery using a distal anastomotic device. RESULTS: The overall 30-day mortality was 0.7% (1/137). No cardiac specific mortality was observed. For each outcome of perioperative myocardial infarction (MI), postoperative stroke and haemorrhage, only a single event was observed for each (n=1/136, 1/138 and 1/136, respectively). The overall device failure rates were low, with the use of additional sutures only reported in a single case with the Magnetic Vascular Port (MVP) device. Anastomotic time ranged from a mean of 3.32 minutes with the MVP device to 20 minutes with the C-Port device. CONCLUSIONS: These results demonstrate the overall acceptable early outcomes of distal anastomotic devices for use in minimally invasive coronary bypass surgery. Future research should focus on designing adequately powered, comparative, randomised trials, focusing on major adverse cardiac and cerebrovascular events (MACCE) outcomes in both the short and long-term, with clear case-by-case reasons for device failure and a comparison of anastomotic times. In this way, we may determine whether such devices will facilitate the minimal access and robotic coronary procedures of the future.
Athanasopoulos LV, Moscarelli M, Speziale G, et al., 2016, Are adjunct subvalvular techniques more effective than isolated restrictive annuloplasty for treating ischemic mitral regurgitation?, Perfusion, Vol: 32, Pages: 92-96, ISSN: 0267-6591
This review focused on whether subvalvular techniques are more effective than isolated restrictive annuloplasty in addressing ischemic mitral regurgitation (MR). Searching identified 445 papers and, following a selection process, we ended up with 10 articles. Two were propensity-matched studies, four retrospective and four prospective, non-randomized studies. The end points of interest were late recurrence of MR, other early echocardiographic outcomes of mitral function and early mortality. All studies focusing on echocardiographic measurements showed improved results in the groups where subvalvular repair techniques were used. In almost all studies, the recurrence of MR postoperatively was less when subvalvular techniques were used. No difference in early or in-hospital mortality was demonstrated in all four studies that included comparisons. We conclude that subvalvular techniques in combination with annuloplasty are safe and may better address ischemic MR than the use of annuloplasty ring alone.
Prakash P, Patne SCU, Singh AK, et al., 2016, PCR and Genotyping for HPV in Cervical Cancer Patients, JOURNAL OF GLOBAL INFECTIOUS DISEASES, Vol: 8, Pages: 100-107, ISSN: 0974-777X
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- Citations: 8
Punjabi PP, 2016, Shakespeare's understanding of human afflictions, PERFUSION-UK, Vol: 31, Pages: 357-357, ISSN: 0267-6591
Ahmad Y, Punjabi PP, 2016, Book review: Textbook of Interventional Cardiology by Eric J Topol, Paul S Teirstein., Perfusion
Shah SH, Punjabi PP, 2016, Book review: Clinical Lipidology. A Companion to Braunwald's Heart Disease by Christie M. Ballantyne., Perfusion
Ng FS, Ariff B, Punjabi PP, et al., 2016, Pyopneumopericardium Secondary to Pericardioesophageal Fistula After Radiofrequency Ablation of Atrial Fibrillation, JACC: Clinical Electrophysiology, Vol: 2, Pages: 397-399, ISSN: 2405-500X
Habib G, Lancellotti P, Antunes MJ, et al., 2016, ESC 2015 guidelines for the treatment of infective endocarditis Task Force for the Treatment of Infective Endocarditis of the European Society of Cardiology (ESC) under the patronage of the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM), GIORNALE ITALIANO DI CARDIOLOGIA, Vol: 17, Pages: 277-319, ISSN: 1827-6806
Punjabi PP, 2016, Scientific Phishing: Fact or Fiction?, PERFUSION-UK, Vol: 31, Pages: 181-181, ISSN: 0267-6591
Anastasiadis K, Murkin J, Antonitsis P, et al., 2016, Use of minimal invasive extracorporeal circulation in cardiac surgery: principles, definitions and potential benefits. A position paper from the Minimal invasive Extra-Corporeal Technologies international Society (MiECTiS)., Interactive Cardiovascular and Thoracic Surgery, Vol: 22, Pages: 647-662, ISSN: 1569-9293
Minimal invasive extracorporeal circulation (MiECC) systems have initiated important efforts within science and technology to further improve the biocompatibility of cardiopulmonary bypass components to minimize the adverse effects and improve end-organ protection. The Minimal invasive Extra-Corporeal Technologies international Society was founded to create an international forum for the exchange of ideas on clinical application and research of minimal invasive extracorporeal circulation technology. The present work is a consensus document developed to standardize the terminology and the definition of minimal invasive extracorporeal circulation technology as well as to provide recommendations for the clinical practice. The goal of this manuscript is to promote the use of MiECC systems into clinical practice as a multidisciplinary strategy involving cardiac surgeons, anaesthesiologists and perfusionists.
De Bonis M, Al-Attar N, Antunes M, et al., 2016, Surgical and interventional management of mitral valve regurgitation: a position statement from the European Society of Cardiology Working Groups on Cardiovascular Surgery and Valvular Heart Disease, EUROPEAN HEART JOURNAL, Vol: 37, Pages: 133-139B, ISSN: 0195-668X
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- Citations: 52
Habib G, Lancellotti P, Antunes MJ, et al., 2015, Guía ESC 2015 sobre el tratamiento de la endocarditis infecciosa, Revista Espanola de Cardiologia, Vol: 69, Pages: 69e1-69e49, ISSN: 1579-2242
Glukhov AV, Balycheva M, Sanchez-Alonso JL, et al., 2015, Direct evidence for microdomain-specific localization and remodeling of functional L-type calcium channels in rat and human atrial myocytes, Circulation, Vol: 132, Pages: 2372-2384, ISSN: 0009-7322
Background—Distinct subpopulations of L-type calcium channels (LTCCs) with different functional properties exist in cardiomyocytes. Disruption of cellular structure may affect LTCC in a microdomain-specific manner and contribute to the pathophysiology of cardiac diseases, especially in cells lacking organized transverse tubules (T-tubules) such as atrial myocytes (AMs).Methods and Results—Isolated rat and human AMs were characterized by scanning ion conductance, confocal, and electron microscopy. Half of AMs possessed T-tubules and structured topography, proportional to cell width. A bigger proportion of myocytes in the left atrium had organized T-tubules and topography than in the right atrium. Super-resolution scanning patch clamp showed that LTCCs distribute equally in T-tubules and crest areas of the sarcolemma, whereas, in ventricular myocytes, LTCCs primarily cluster in T-tubules. Rat, but not human, T-tubule LTCCs had open probability similar to crest LTCCs, but exhibited ≈40% greater current. Optical mapping of Ca2+ transients revealed that rat AMs presented ≈3-fold as many spontaneous Ca2+ release events as ventricular myocytes. Occurrence of crest LTCCs and spontaneous Ca2+ transients were eliminated by either a caveolae-targeted LTCC antagonist or disrupting caveolae with methyl-β-cyclodextrin, with an associated ≈30% whole-cell ICa,L reduction. Heart failure (16 weeks post–myocardial infarction) in rats resulted in a T-tubule degradation (by ≈40%) and significant elevation of spontaneous Ca2+ release events. Although heart failure did not affect LTCC occurrence, it led to ≈25% decrease in T-tubule LTCC amplitude.Conclusions—We provide the first direct evidence for the existence of 2 distinct subpopulations of functional LTCCs in rat and human AMs, with their biophysical properties modulated in heart failure in a microdomain-specific manner.
, 2015, The 2015 ESC Guidelines for the management of infective endocarditis., Eur Heart J, Vol: 36, Pages: 3036-3037
Take-home message of the full 2015 ESC Guidelines, also endorsed by the European Association for Cardio-Thoracic Surgery, European Association of Nuclear Medicine, and European Society of Clinical Microbiology and Infectious Diseases.
Habib G, Lancellotti P, Antunes MJ, et al., 2015, Zatwierdzone przez: <i>European Association for Cardio</i>-<i>Thoracic Surgery</i> (EACTS) oraz <i>European Association of Nuclear Medicine</i> (EANM), KARDIOLOGIA POLSKA, Vol: 73, Pages: 963-1027, ISSN: 0022-9032
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- Citations: 18
Sanchez-Alonso JL, Poulet CE, Schobesberger S, et al., 2015, L-type Calcium Channels Localization and Function are Affected by Microdomain Remodelling in Human Failing Cardiomyocytes, Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association (AHA), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
Punjabi PP, 2015, Revisiting the Hippocratic Oath, PERFUSION-UK, Vol: 30, Pages: 610-610, ISSN: 0267-6591
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- Citations: 1
Hausenloy DJ, Candilio L, Evans R, et al., 2015, Remote Ischemic Preconditioning and Outcomes of Cardiac Surgery, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 373, Pages: 1408-1417, ISSN: 0028-4793
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- Citations: 503
Rana BS, Calvert PA, Punjabi PP, et al., 2015, Role of percutaneous mitral valve repair in the contemporary management of mitral regurgitation, HEART, Vol: 101, Pages: 1531-1539, ISSN: 1355-6037
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- Citations: 2
Moscarelli M, Angelini GD, Suleiman S, et al., 2015, Remote ischaemic preconditioning: is it a flag on the field?, PERFUSION-UK, Vol: 30, Pages: 438-447, ISSN: 0267-6591
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- Citations: 6
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