Publications
296 results found
Dexter F, 2015, Statistical Analysis of PACU Fast-Tracking Bypass, JOURNAL OF PERIANESTHESIA NURSING, Vol: 30, Pages: 268-268, ISSN: 1089-9472
Dexter F, 2015, Statistical Analysis of PACU Fast-Tracking Bypass., J Perianesth Nurs, Vol: 30
Zipes DP, Jalife J, Petrone G, et al., 2015, Cardiac Electrophysiology: From Cell to Bedside, 6th edition, PERFUSION-UK, Vol: 30, Pages: 431-432, ISSN: 0267-6591
Chambers JC, Loh M, Lehne B, et al., 2015, Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study, The Lancet Diabetes & Endocrinology, Vol: 3, Pages: 526-534, ISSN: 2213-8587
BackgroundIndian Asians, who make up a quarter of the world's population, are at high risk of developing type 2 diabetes. We investigated whether DNA methylation is associated with future type 2 diabetes incidence in Indian Asians and whether differences in methylation patterns between Indian Asians and Europeans are associated with, and could be used to predict, differences in the magnitude of risk of developing type 2 diabetes.MethodsWe did a nested case-control study of DNA methylation in Indian Asians and Europeans with incident type 2 diabetes who were identified from the 8-year follow-up of 25 372 participants in the London Life Sciences Prospective Population (LOLIPOP) study. Patients were recruited between May 1, 2002, and Sept 12, 2008. We did epigenome-wide association analysis using samples from Indian Asians with incident type 2 diabetes and age-matched and sex-matched Indian Asian controls, followed by replication testing of top-ranking signals in Europeans. For both discovery and replication, DNA methylation was measured in the baseline blood sample, which was collected before the onset of type 2 diabetes. Epigenome-wide significance was set at p<1 × 10−7. We compared methylation levels between Indian Asian and European controls without type 2 diabetes at baseline to estimate the potential contribution of DNA methylation to increased risk of future type 2 diabetes incidence among Indian Asians.Findings1608 (11·9%) of 13 535 Indian Asians and 306 (4·3%) of 7066 Europeans developed type 2 diabetes over a mean of 8·5 years (SD 1·8) of follow-up. The age-adjusted and sex-adjusted incidence of type 2 diabetes was 3·1 times (95% CI 2·8–3·6; p<0·0001) higher among Indian Asians than among Europeans, and remained 2·5 times (2·1–2·9; p<0·0001) higher after adjustment for adiposity, physical activity, family history of type 2 diabetes, and baselin
Fiorentino F, Angelini GD, Suleiman M-S, et al., 2015, Investigating the effect of remote ischaemic preconditioning on biomarkers of stress and injury-related signalling in patients having isolated coronary artery bypass grafting or aortic valve replacement using cardiopulmonary bypass: study protocol for a randomized controlled trial, Trials, Vol: 16, ISSN: 1745-6215
Background: Ischaemia-reperfusion injury occurs during heart surgery that uses cardiopulmonary bypass (CPB) andcardioplegic arrest. It is hypothesised that remote ischaemic preconditioning (RIPC) protects the heart against suchinjury. Despite the numerous studies investigating the protective effects of RIPC, there is still uncertainty about theinterpretation of the findings as well as conflicting results between studies. The objective of this trial is toinvestigate the cardioprotective effect of RIPC in patients having coronary artery bypass grafting (CABG) or aorticvalve replacement surgery. This will be achieved by estimating the effect of the intervention in the two groups ofpathologies and by investigating the signalling mechanisms that may underpin the cardioprotective effect.Methods/Design: A two-centre randomised controlled trial will be used to investigate the effects of RIPC in twopathologies: patients having isolated CABG and those having aortic valve replacement surgery (AVR) with CPB.Participants will be randomised to RIPC or control (sham RIPC), stratified by surgical stratum. The interventionwill be delivered by a research nurse. Data will be collected by a research nurse blinded to the intervention.The patient and the theatre staff are also blinded to the allocation. Markers of myocardial injury and inflammationwill be measured in myocardial biopsies and in blood samples at different times.Discussion: This trial is designed to investigate whether RIPC will reduce myocardial injury and inflammationfollowing heart surgery and whether there is a difference in effect between participants having CABG or AVR.This trial is a unique opportunity to study the mechanisms associated with RIPC using human myocardial tissueand blood, and to relate these to the extent of myocardial injury/protection.Trial registration: Current Controlled Trials ISRCTN33084113 (25 March 2013).
Chan KMJ, Jarral OA, Jarral RA, et al., 2015, Avoiding tension in left internal mammary artery to left anterior descending coronary artery anastomosis during coronary artery bypass graft surgery, Annals of the Royal College of Surgeons of England, Vol: 95, Pages: 73-73, ISSN: 1478-7083
Punjabi PP, 2015, The power of negative thinking - The glass is half full, PERFUSION-UK, Vol: 30, Pages: 92-92, ISSN: 0267-6591
Baig K, Punjabi P, 2015, Heart valve surgery, Surgery (United Kingdom), Vol: 33, Pages: 67-72, ISSN: 0263-9319
With an ageing population, the incidence of degenerative valve disease is increasing and subsequently more patients are being diagnosed and being referred for intervention. Improvements in diagnostic imaging techniques have facilitated earlier diagnosis and strategic planning of intervention. Decision making can be complex and challenging, hence valvular heart disease is now managed through a multidisciplinary 'heart team' approach and guidelines have been developed that have a strong evidence base. Advances in perioperative management and operative techniques have resulted in reductions in morbidity and mortality associated with surgery. Surgical therapy for valvular heart disease is associated with excellent symptomatic improvements and long-term outcomes. The advent of transcatheter valves has revolutionized the management of aortic valve disease, especially in high risk patients that were previously deemed inoperable.
Punjabi PP, 2015, Surgeon-specific mortality data: bury your head in the sand, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 47, Pages: 346-347, ISSN: 1010-7940
Moscarelli M, Punjabi PP, Miroslav GI, et al., 2015, Myocardial conditioning techniques in off-pump coronary artery bypass grafting, JOURNAL OF CARDIOTHORACIC SURGERY, Vol: 10, ISSN: 1749-8090
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- Citations: 2
Moscarelli M, Punjabi PP, 2015, Predictors of recurrent chronic ischemic mitral regurgitation after mitral valve repair surgery, Secondary Mitral Valve Regurgitation, Pages: 185-191, ISBN: 9781447164876
Chronic ischemic mitral regurgitation rises from a multifactorial and dynamic etiology, thereby achieving a durable repair remains still a challenge. Recurrences in some series range from 10 to 30 % (McGee et al., J Thorac Cardiovasc Surg 128(6):916–924, 2004; Hung et al., Circulation 110(11 Suppl 1):II85–II90, 2004), besides there are reports of recrudescence even at 5 years from surgery (Gelsomino et al., Eur Heart J 29(2):231–240, 2008). It plays a crucial momentum the understanding of the predictors of repair and durability and some of them are already codifi ed in the literature (Joint Task Force on the Management of Valvular Heart Disease of the European Society of C, European Association for Cardio-Thoracic S et al. Eur Heart J 33(19):2451–2496, 2012) as: left ventricular volume, tenting area, coaptation depth, interpapillary muscles distance, tethering angles, plus others ancillary. However these echocardiographic variables have been ’tested’ mainly on patients undergoing restrictive annuloplasty alone, which although is the most performed repair technique, cannot address all the types of ischemic mitral regurgitation. New surgical strategies have been recently proposed (Boyd, Circ J 77(8):1952–1956, 2013) and adopted and, in the near future they might be considered as ’game changing’ techniques, and depending on their result the predictors of failure of repair could be restructured.
Grapsa J, Cabrita IZ, Jakaj G, et al., 2015, Strain balance of papillary muscles as a prerequisite for successful mitral valve repair in patients with mitral valve prolapse due to fibroelastic deficiency, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol: 16, Pages: 53-61, ISSN: 2047-2404
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- Citations: 3
Habib G, Lancellotti P, Antunes MJ, et al., 2015, [2015 ESC Guidelines for the management of infective endocarditis]., Kardiol Pol, Vol: 73, Pages: 963-1027
Baig K, Punjabi P, 2015, Heart valve surgery, Surgery (United Kingdom), ISSN: 0263-9319
With an ageing population, the incidence of degenerative valve disease is increasing and subsequently more patients are being diagnosed and being referred for intervention. Improvements in diagnostic imaging techniques have facilitated earlier diagnosis and strategic planning of intervention. Decision making can be complex and challenging, hence valvular heart disease is now managed through a multidisciplinary 'heart team' approach and guidelines have been developed that have a strong evidence base. Advances in perioperative management and operative techniques have resulted in reductions in morbidity and mortality associated with surgery. Surgical therapy for valvular heart disease is associated with excellent symptomatic improvements and long-term outcomes. The advent of transcatheter valves has revolutionized the management of aortic valve disease, especially in high risk patients that were previously deemed inoperable.
Balycheva M, Glukhov A, Schobesberger S, et al., 2014, Increased Open Probability of L-type Calcium Channels Localized in T-tubules in Patients With Chronic Atrial Fibrillation: Role of Channel Subunits, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
Punjabi PP, 2014, Essentials of Operative Cardiac Surgery, Publisher: Springer, ISBN: 9783319099064
This book will aid surgeons in mastering the essential skills necessary in the ever expanding field of cardiac surgery.
Bhakri KP, Mulholland J, Punjabi PP, 2014, Understanding innovations in the evolving practice of blood and crystalloid cardioplegia, PERFUSION-UK, Vol: 29, Pages: 505-510, ISSN: 0267-6591
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- Citations: 7
Punjabi PP, 2014, Perfusion - the rise of the Impact Factor, PERFUSION-UK, Vol: 29, Pages: 482-482, ISSN: 0267-6591
Kanaganayagam GS, Moscarelli M, Punjabi PP, et al., 2014, Feeling dizzy? A giant incidental finding, EUROPEAN HEART JOURNAL, Vol: 35, Pages: 2343-2343, ISSN: 0195-668X
Attaran S, Harling L, Ashrafian H, et al., 2014, Off-pump versus on-pump revascularization in females: a meta-analysis of observational studies, PERFUSION-UK, Vol: 29, Pages: 385-396, ISSN: 0267-6591
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- Citations: 9
Sarvananthan S, Punjabi PP, 2014, In atrial fibrillation, dabigatran had similar efficacy to warfarin but caused less bleeding in higher GFR, Annals of Internal Medicine, Vol: 161, ISSN: 1539-3704
Punjabi PP, 2014, Collective Excellence: The "Heart" MDT, PERFUSION-UK, Vol: 29, Pages: 284-284, ISSN: 0267-6591
Ordiene R, Sarvananthan S, Punjabi PP, 2014, Book Review: "150 ECG Problems" (Fourth edition)., Perfusion, Vol: 29
Hing JX, Macys A, Elshiekh MA, et al., 2014, Haemolysis: the harbinger of recurrent mitral regurgitation after mitral valve repair, PERFUSION-UK, Vol: 29, Pages: 184-186, ISSN: 0267-6591
Punjabi PP, 2014, The Science of Politics and The Politicization of Science, PERFUSION-UK, Vol: 29, Pages: 101-101, ISSN: 0267-6591
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- Citations: 1
Punjabi PP, Taylor KM, 2014, The science and practice of cardiopulmonary bypass: From cross circulation to ECMO and SIRS., Global Cardiology Science & Practice, Vol: 32, Pages: 249-260, ISSN: 2305-7823
Punjabi PP, 2013, Indispensible? No, not really, but nearly, PERFUSION-UK, Vol: 28, Pages: 470-471, ISSN: 0267-6591
Treede H, Dr M, Thiis JJ, et al., 2013, Clinical outcomes through 12 months in patients with degenerative mitral regurgitation treated with the MitraClip® device in the ACCESS-EUrope Phase I trial CONFERENCE DISCUSSION, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 44, Pages: E288-E288, ISSN: 1010-7940
Koertzen M, Punjabi PP, Lockwood GG, 2013, Pre-operative serum albumin concentration as a predictor of mortality and morbidity following cardiac surgery, PERFUSION-UK, Vol: 28, Pages: 390-394, ISSN: 0267-6591
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- Citations: 22
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