I am a Clinical Reader in Paediatric Critical Care in the Department of Surgery and Cancer at Imperial College, Honorary Consultant in Paediatric Intensive Care at St Mary's Hospital, and Deputy Director of the Imperial Centre for Paediatrics and Child Health (PaeCH).
My main research interests are focused on pragmatic clinical trials (particularly related to paediatric ventilation), critical care epidemiology and the use of artificial intelligence (AI) to improve decision-making in critically ill children.
I graduated with an MBBS from JIPMER, Pondicherry University, India in 1995 and moved to the UK for postgraduate medical training. Following my MRCP (UK) degree, London in 1997, I completed postgraduate training in the North Thames Deanery from 1998-2005, obtaining a CCST in Paediatrics (Paediatric Intensive Care Medicine). My dual passion for research and information technology led me to take time out from clinical training between 2001 and 2004 to complete an MD(Res) in Medical Informatics Applications (University of London), during which I conducted a series of studies examining the accuracy and clinical utility of a computerised diagnostic decision support system called Isabel.
I continued doing clinical research while in a full-time NHS clinical post at Great Ormond Street Hospital (Children's Acute Transport Service) between 2005 and 2021, and established an internationally recognised track record of funded clinical research in paediatric critical care and emergency transport. I joined Imperial College as a clinical-academic in October 2021, working in Prof Anthony Gordon's (adult critical care) research group.
I am currently the Chair of the Paediatric Critical Care Society Study Group (PCCS-SG), a multidisciplinary group of UK paediatric critical care researchers.
In 2023, I was appointed Deputy Director of the Imperial Centre for Paediatrics and Child Health.
I have led several national studies funded by the National Institute of Health and Care Research (NIHR):
- DEPICT (mixed methods study of the impact of timely access to intensive care for children): DEPICT was the largest ever study conducted in paediatric critical care transport. Findings influenced national quality standards for the care of critically ill children.
- FIRST-ABC master protocol (noninvasive respiratory support in critically ill children): The two FIRST ABC clinical trials were the largest clinical trials ever conducted in paediatric noninvasive respiratory support, and influenced international guidelines.
I have co-led other impactful clinical trials in paediatric critical care:
- CATCH (comparison of impregnated central venous catheters with standard catheters)
- Oxy-PICU (conservative versus liberal oxygen saturation targets)
- PRESSURE (permissive blood pressure target versus standard care).
I am currently:
- Chief Investigator for BACHb, a two-stratum NIHR-funded clinical trial of respiratory support in infants with bronchiolitis
- Co-investigator for REMAP-CAP Influenza, UK national platform trial evaluating treatments for patients hospitalised due to influenza
- Co-investigator for Rosetrees Trust funded study of extending the AI Clinician to children with sepsis
et al., 2023, Association of Extubation Failure Rates With High-Flow Nasal Cannula, Continuous Positive Airway Pressure, and Bilevel Positive Airway Pressure vs Conventional Oxygen Therapy in Infants and Young Children A Systematic Review and Network Meta-Analysis, Jama Pediatrics, Vol:177, ISSN:2168-6203, Pages:774-781
et al., 2023, Hospital admissions linked to SARS-CoV-2 infection in children and adolescents: cohort study of 3.2 million first ascertained infections in England, Bmj-british Medical Journal, Vol:382, ISSN:0959-535X
et al., 2023, Emergency Inter-Hospital Transfer of Children to PICUs in the United Kingdom: Qualitative Exploration of Parents' Experiences of Retrieval Teams., Pediatr Crit Care Med, ISSN:1529-7535
et al., 2023, Operational Definitions Related to Pediatric Ventilator Liberation, Chest, Vol:163, ISSN:0012-3692, Pages:1130-1143
et al., 2023, Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study, The Lancet Rheumatology, Vol:5, ISSN:2665-9913, Pages:e184-e199