Dr Padmanabhan Ramnarayan (Ram)

Faculty of Medicine, Department of Surgery & Cancer

Reader in Paediatric Critical Care

Contact

Location

508Medical SchoolSt Mary's Campus

Summary

I am a Clinical Reader in Paediatric Critical Care in the Department of Surgery and Cancer at Imperial College, Honorary Consultant in Paediatric Intensive Care at St Mary's Hospital, and Deputy Director of the Imperial Centre for Paediatrics and Child Health (PaeCH).

My main research interests are focused on pragmatic clinical trials (particularly related to paediatric ventilation), critical care epidemiology and the use of artificial intelligence (AI) to improve decision-making in critically ill children.

I graduated with an MBBS from JIPMER, Pondicherry University, India in 1995 and moved to the UK for postgraduate medical training. Following my MRCP (UK) degree, London in 1997, I completed postgraduate training in the North Thames Deanery from 1998-2005, obtaining a CCST in Paediatrics (Paediatric Intensive Care Medicine). My dual passion for research and information technology led me to take time out from clinical training between 2001 and 2004 to complete an MD(Res) in Medical Informatics Applications (University of London), during which I conducted a series of studies examining the accuracy and clinical utility of a computerised diagnostic decision support system called Isabel.

I continued doing clinical research while in a full-time NHS clinical post at Great Ormond Street Hospital (Children's Acute Transport Service) between 2005 and 2021, and established an internationally recognised track record of funded clinical research in paediatric critical care and emergency transport. I joined Imperial College as a clinical-academic in October 2021, working in Prof Anthony Gordon's (adult critical care) research group.

I am currently the Chair of the Paediatric Critical Care Society Study Group (PCCS-SG), a multidisciplinary group of UK paediatric critical care researchers.

In 2023, I was appointed Deputy Director of the Imperial Centre for Paediatrics and Child Health.

Research achievements

I have led several national studies funded by the National Institute of Health and Care Research (NIHR):

DEPICT (mixed methods study of the impact of timely access to intensive care for children): DEPICT was the largest ever study conducted in paediatric critical care transport. Findings influenced national quality standards for the care of critically ill children.
FIRST-ABC master protocol (noninvasive respiratory support in critically ill children): The two FIRST ABC clinical trials were the largest clinical trials ever conducted in paediatric noninvasive respiratory support, and influenced international guidelines.

I have co-led other impactful clinical trials in paediatric critical care:

CATCH (comparison of impregnated central venous catheters with standard catheters)
Oxy-PICU (conservative versus liberal oxygen saturation targets)
PRESSURE (permissive blood pressure target versus standard care).

I am currently:

Chief Investigator for BACHb, a two-stratum NIHR-funded clinical trial of respiratory support in infants with bronchiolitis
Co-investigator for REMAP-CAP Influenza, UK national platform trial evaluating treatments for patients hospitalised due to influenza
Co-investigator for Rosetrees Trust funded study of extending the AI Clinician to children with sepsis

Publications

Journals

Iyer NP, Rotta AT, Essouri S, et al.Iyer NP, Rotta AT, Essouri S, Fioretto JR, Craven HJ, Whipple EC, Ramnarayan P, Abu-Sultaneh S, Khemani RG close, 2023, Association of Extubation Failure Rates With High-Flow Nasal Cannula, Continuous Positive Airway Pressure, and Bilevel Positive Airway Pressure vs Conventional Oxygen Therapy in Infants and Young Children A Systematic Review and Network Meta-Analysis, Jama Pediatrics, Vol:177, ISSN:2168-6203, Pages:774-781

Wilde H, Tomlinson C, Mateen BA, et al.Wilde H, Tomlinson C, Mateen BA, Selby D, Kanthimathinathan HK, Ramnarayan P, Du Pre P, Johnson M, Pathan N, Gonzalez-Izquierdo A, Lai AG, Gurdasani D, Pagel C, Denaxas S, Vollmer S, Brown K close, 2023, Hospital admissions linked to SARS-CoV-2 infection in children and adolescents: cohort study of 3.2 million first ascertained infections in England, Bmj-british Medical Journal, Vol:382, ISSN:0959-535X

Evans REC, Barber V, Ramnarayan P, et al.Evans REC, Barber V, Ramnarayan P, Davies P, Wray J, DEPICT Study group close, 2023, Emergency Inter-Hospital Transfer of Children to PICUs in the United Kingdom: Qualitative Exploration of Parents' Experiences of Retrieval Teams., Pediatr Crit Care Med, ISSN:1529-7535

Abu-Sultaneh S, Iyer NP, Fernandez A, et al.Abu-Sultaneh S, Iyer NP, Fernandez A, Gaies M, Gonzalez-Dambrauskas S, Hotz JC, Kneyber MCJ, Lopez-Fernandez YM, Rotta AT, Werho DK, Baranwal AK, Blackwood B, Craven HJ, Curley MAQ, Essouri S, Fioretto JR, Hartmann SMM, Jouvet P, Korang SK, Rafferty GF, Ramnarayan P, Rose L, Tume LN, Whipple EC, Wong JJM, Emeriaud G, Mastropietro CW, Napolitano N, Newth CJL, Khemani RG close, 2023, Operational Definitions Related to Pediatric Ventilator Liberation, Chest, Vol:163, ISSN:0012-3692, Pages:1130-1143

Channon-Wells S, Vito O, McArdle AJ, et al.Channon-Wells S, Vito O, McArdle AJ, Seaby EG, Patel H, Shah P, Pazukhina E, Wilson C, Broderick C, D'Souza G, Keren I, Nijman RG, Tremoulet A, Munblit D, Ulloa-Gutierrez R, Carter MJ, Ramnarayan P, De T, Hoggart C, Whittaker E, Herberg JA, Kaforou M, Cunnington AJ, Blyuss O, Levin M, Chouli M, Hamadouche N, Ladj MS, Agrimbau Vázquez J, Carmona R, Collia AG, Ellis A, Natta D, Pérez L, Rubiños M, Veliz N, Yori S, Britton PN, Burgner DP, Carey E, Crawford NW, Giuliano H, McMinn A, Wong S, Wood N, Holter W, Krainz M, Ulreich R, Zurl C, Dehoorne J, Haerynck F, Hoste L, Schelstraete P, Vandekerckhove K, Willems J, Almeida Farias CG, Almeida FJ, Alves Leal I, Araujo da Silva AR, Araujo e Silva AE, Barreiro STA, Bomfim Prado da Silva DG, Cervi MC, dos Santos Naja Cardoso MV, Henriques Teixeira C, Jarovsky D, Martins Araujo J, Naaman Berezin E, Palazzi Sáfadi MA, Paternina-de la Ossa RA, Souza Vieira C, Dimitrova A, Ganeva M, Stefanov S, Telcharova-Mihaylovska A, Biggs CM, Lopez A, Scuccimarri R, Tan R, Wasserman S, Withington D, Ampuero C, Aravena J, Bustos B R, Casanova D, Cruces P, Diaz F, García-Salum T, Godoy L, Medina RA, Valenzuela Galaz G, Camacho-Moreno G, Avila-Aguero ML, Brenes-Chacón H, Camacho-Badilla K, Ivankovich-Escoto G, Naranjo-Zuniga G, Soriano-Fallas A, Ulloa-Gutierrez R, Yock-Corrales A, Amer MA, Abdelmeguid Y, Ahmed YHHZ, Badib A, Badreldin K, Elkhashab Y, Heshmat H, Hussein A, Mohamed Hussein AH, Ibrahim S, Shoman W, Yakout RM, Heinonen S, Angoulvant F, Belot A, Ouldali N, Beske F, Heep A, Masjosthusmann K, Reiter K, van den Heuvel I, von Both U, Agrafiotou A, Antachopoulos C, Charisi K, Eleftheriou I, Farmaki E, Fotis L, Kafetzis D, Koletsi P, Kourtesi K, Lampidi S, Liakopoulou T, Maritsi D, Michailidou E, Milioudi M, Mparmpounaki I, Papadimitriou E, Papaevangelou V, Roilides E, Tsiatsiou O, Tsolas G, Tsolia M, Vantsi P, Banegas Pineda LY, Borjas Aguilar KL, Cantillano Quintero EM, Ip P, Kwan MYW, Kwok J, Lau YL, To K, Wong JSC, David M, Farkas D, Ka close, 2023, Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study, The Lancet Rheumatology, Vol:5, ISSN:2665-9913, Pages:e184-e199

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