Imperial College London

ProfessorPatrickSerruys

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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p.serruys

 
 
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Location

 

c/o Prof Kim FoxGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

926 results found

Ozaki Y, Katagiri Y, Onuma Y, Amano T, Muramatsu T, Kozuma K, Otsuji S, Ueno T, Shiode N, Kawai K, Tanaka N, Ueda K, Akasaka T, Hanaoka KI, Uemura S, Oda H, Katahira Y, Kadota K, Kyo E, Sato K, Sato T, Shite J, Nakao K, Nishino M, Hikichi Y, Honye J, Matsubara T, Mizuno S, Muramatsu T, Inohara T, Kohsaka S, Michishita I, Yokoi H, Serruys PW, Ikari Y, Nakamura Met al., 2018, CVIT expert consensus document on primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) in 2018, Cardiovascular Intervention and Therapeutics, Vol: 33, Pages: 178-203, ISSN: 1868-4300

While primary percutaneous coronary intervention (PCI) has significantly contributed to improve the mortality in patientswith ST segment elevation myocardial infarction even in cardiogenic shock, primary PCI is a standard of care in most ofJapanese institutions. Whereas there are high numbers of available facilities providing primary PCI in Japan, there are noclear guidelines focusing on procedural aspect of the standardized care. Whilst updated guidelines for the managementof acute myocardial infarction were recently published by European Society of Cardiology, the following major changesare indicated; (1) radial access and drug-eluting stent over bare metal stent were recommended as Class I indication, and(2) complete revascularization before hospital discharge (either immediate or staged) is now considered as Class IIa recommendation.Although the primary PCI is consistently recommended in recent and previous guidelines, the device lagfrom Europe, the frequent usage of coronary imaging modalities in Japan, and the difference in available medical therapyor mechanical support may prevent direct application of European guidelines to Japanese population. The Task Force onPrimary Percutaneous Coronary Intervention of the Japanese Association of Cardiovascular Intervention and Therapeutics(CVIT) has now proposed the expert consensus document for the management of acute myocardial infarction focusing onprocedural aspect of primary PCI.

Journal article

Chiastra C, Iannaccone F, Grundeken MJ, Gijsen FJH, Segers P, De Beule M, Serruys PW, Wykrzykowska JJ, van der Steen AFW, Wentzel JJet al., 2016, Coronary fractional flow reserve measurements of a stenosed side branch: a computational study investigating the influence of the bifurcation angle, Biomedical Engineering Online, Vol: 15, ISSN: 1475-925X

BackgroundCoronary hemodynamics and physiology specific for bifurcation lesions was not well understood. To investigate the influence of the bifurcation angle on the intracoronary hemodynamics of side branch (SB) lesions computational fluid dynamics simulations were performed.MethodsA parametric model representing a left anterior descending—first diagonal coronary bifurcation lesion was created according to the literature. Diameters obeyed fractal branching laws. Proximal and distal main branch (DMB) stenoses were both set at 60 %. We varied the distal bifurcation angles (40°, 55°, and 70°), the flow splits to the DMB and SB (55 %:45 %, 65 %:35 %, and 75 %:25 %), and the SB stenoses (40, 60, and 80 %), resulting in 27 simulations. Fractional flow reserve, defined as the ratio between the mean distal stenosis and mean aortic pressure during maximal hyperemia, was calculated for the DMB and SB (FFRSB) for all simulations.ResultsThe largest differences in FFRSB comparing the largest and smallest bifurcation angles were 0.02 (in cases with 40 % SB stenosis, irrespective of the assumed flow split) and 0.05 (in cases with 60 % SB stenosis, flow split 55 %:45 %). When the SB stenosis was 80 %, the difference in FFRSB between the largest and smallest bifurcation angle was 0.33 (flow split 55 %:45 %). By describing the ΔPSB−QSB relationship using a quadratic curve for cases with 80 % SB stenosis, we found that the curve was steeper (i.e. higher flow resistance) when bifurcation angle increases (ΔP = 0.451*Q + 0.010*Q 2 and ΔP = 0.687*Q + 0.017*Q 2 for 40° and 70° bifurcation angle, respectively). Our analyses revealed complex hemodynamics in all cases with evident counter-rotating helical flow structures. Larger bifurcation angles resulted in more pronounced helical flow structures (i.e. higher helicity intensity), when 60 or 80 % SB stenoses were present. A good correlation (R2 = 0.80) between the SB pressure drop and helici

Journal article

Oemrawsingh RM, Cheng JM, Akkerhuis KM, Kardys I, Degertekin M, van Geuns RJ, Daemen J, Boersma E, Serruys PW, van Domburg RTet al., 2016, High-sensitivity C-reactive protein predicts 10-year cardiovascular outcome after percutaneous coronary intervention, Eurointervention, Vol: 12, Pages: 345-351, ISSN: 1969-6213

AIMS: This study aimed to evaluate the prognostic value of high-sensitivity C-reactive protein (hsCRP) during 10-year follow-up after percutaneous coronary intervention (PCI). METHODS AND RESULTS: Between April and October 2002, hsCRP was measured in 468 all-comer patients who underwent PCI with sirolimus-eluting stent implantation for stable coronary artery disease or acute coronary syndrome. The primary endpoint was the composite of all-cause mortality or myocardial infarction at 10-year follow-up. Kaplan-Meier event curves displayed ongoing divergence of the hsCRP groups (hsCRP <1 mg/L: 14.7% vs. 1-3 mg/L: 31.1% vs. >3 mg/L: 43.1%). After adjustment for established cardiovascular risk factors and clinical presentation in a Cox regression model, higher CRP levels were associated with a higher incidence of the composite endpoint (>3 mg/L vs. <1 mg/L: HR 2.87, 95% CI: 1.69-4.87, p<0.001; 1-3 mg/L vs. <1 mg/L: HR 2.30, 95% CI: 1.31-4.03, p=0.004). Although adding hsCRP to a prediction model containing conventional cardiovascular risk factors did not significantly improve discriminatory power (area under the receiver operating characteristic curve 0.71 to 0.73, p=0.56), hsCRP was able to improve risk classification (net reclassification index=0.40, p=<0.001). CONCLUSIONS: In patients undergoing PCI, higher CRP levels at the time of the procedure are predictive for 10-year mortality and myocardial infarction. High-sensitivity CRP may be a useful biomarker to improve further risk assessment in patients undergoing PCI.

Journal article

Sotomi Y, Tateishi H, Suwannasom P, Dijkstra J, Eggermont J, Liu S, Tenekecioglu E, Zheng Y, Abdelghani M, Cavalcante R, de Winter RJ, Wykrzykowska JJ, Onuma Y, Serruys PW, Kimura Tet al., 2016, Quantitative assessment of the stent/scaffold strut embedment analysis by optical coherence tomography, International Journal of Cardiovascular Imaging, Vol: 32, Pages: 871-883, ISSN: 1875-8312

The degree of stent/scaffold embedment could be a surrogate parameter of the vessel wall-stent/scaffold interaction and could have biological implications in the vascular response. We have developed a new specific software for the quantitative evaluation of embedment of struts by optical coherence tomography (OCT). In the present study, we described the algorithm of the embedment analysis and its reproducibility. The degree of embedment was evaluated as the ratio of the embedded part versus the whole strut height and subdivided into quartiles. The agreement and the inter- and intra-observer reproducibility were evaluated using the kappa and the interclass correlation coefficient (ICC). A total of 4 pullbacks of OCT images in 4 randomly selected coronary lesions with 3.0 × 18 mm devices [2 lesions with Absorb BVS and 2 lesions with XIENCE (both from Abbott Vascular, Santa Clara, CA, USA)] from Absorb Japan trial were evaluated by two investigators with QCU-CMS software version 4.69 (Leiden University Medical Center, Leiden, The Netherlands). Finally, 1481 polymeric struts in 174 cross-sections and 1415 metallic struts in 161 cross-sections were analyzed. Inter- and intra-observer reproducibility of quantitative measurements of embedment ratio and categorical assessment of embedment in Absorb BVS and XIENCE had excellent agreement with ICC ranging from 0.958 to 0.999 and kappa ranging from 0.850 to 0.980. The newly developed embedment software showed excellent reproducibility. Computer-assisted embedment analysis could be a feasible tool to assess the strut penetration into the vessel wall that could be a surrogate of acute injury caused by implantation of devices.

Journal article

Tenekecioglu E, Farooq V, Bourantas CV, Silva RC, Onuma Y, Yilmaz M, Serruys PWet al., 2016, Bioresorbable scaffolds: a new paradigm in percutaneous coronary intervention, BMC Cardiovascular Disorders, Vol: 16, ISSN: 1471-2261

Journal article

Simsek C, Karanasos A, Magro M, Garcia-Garcia HM, Onuma Y, Regar E, Boersma E, Serruys PW, van Geuns RJet al., 2016, Long-term invasive follow-up of the everolimus-eluting bioresorbable vascular scaffold: five-year results of multiple invasive imaging modalities, Eurointervention, Vol: 11, Pages: 996-1003, ISSN: 1969-6213

AIMS: Invasive imaging modalities have shown restoration of vasomotion, prevention of restenosis and, most importantly, increase in lumen area between six months and two years after first-generation everolimus-eluting bioresorbable vascular scaffold (Absorb BVS) implantation. Our aim was to assess whether these positive findings were sustained in the long term. METHODS AND RESULTS: Patients included in the ABSORB cohort A from the Thoraxcenter Rotterdam cohort underwent coronary catheterisation including angiography, intravascular ultrasound (IVUS), virtual histology, optical coherence tomography (OCT) and vasomotion testing at five years. Eight out of 16 patients underwent catheterisation and scaffold assessment with multiple imaging modalities. A trend towards an increase in minimum luminal diameter was observed between two and five years by angiography (1.95±0.37 mm vs. 2.14±0.38 mm; p=0.09). IVUS data showed an increase in mean lumen area at five years (6.96±1.13 mm2) compared to six months (6.17±0.74 mm2; p=0.06) and two years (6.56±1.16 mm2; p=0.12), primarily due to a persistent reduction in plaque area size between six months and five years (9.17±1.86 mm2 vs. 7.57±1.63 mm2; p=0.03). The necrotic core area was reduced at five years compared to post-procedural results. In OCT, an increase in mean and minimal luminal area was observed. Moreover, no scaffold struts could be identified and a smooth endoluminal lining was observed. The scaffolded coronary segment did not show signs of endothelial dysfunction with acetylcholine testing. CONCLUSIONS: At five years, the Absorb BVS is no longer discernible by any invasive imaging method and endothelial function is restored. Late luminal enlargement persists up to five years of follow-up without adaptive vessel remodelling.

Journal article

Brener SJ, Maehara A, Mintz GS, Weisz G, de Bruyne B, Serruys PW, Stone GWet al., 2015, Effect of Prior Aspirin Treatment on Patients With Acute Coronary Syndromes: Insights From the PROSPECT Study, JOURNAL OF INVASIVE CARDIOLOGY, Vol: 27, Pages: 536-541, ISSN: 1042-3931

Journal article

Campos CM, Stanetic BM, Farooq V, Walsh S, Ishibashi Y, Onuma Y, Garcia-Garcia HM, Escaned J, Banning A, Serruys PWet al., 2015, Risk stratification in 3-vessel coronary artery disease: Applying the SYNTAX Score II in the Heart Team Discussion of the SYNTAX II trial, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 86, Pages: E229-E238, ISSN: 1522-1946

Journal article

Chieffo A, Van Mieghem NM, Tchetche D, Dumonteil N, Giustino G, Van der Boon RMA, Pierri A, Marcheix B, Misuraca L, Serruys PW, Millischer D, Carrie D, de Jaegere PPT, Colombo Aet al., 2015, Impact of Mixed Aortic Valve Stenosis on VARC-2 Outcomes and Postprocedural Aortic Regurgitation in Patients Undergoing Transcatheter Aortic Valve Implantation: Results From the International Multicentric Study PRAGMATIC (Pooled Rotterdam-Milan-Toulouse in Collaboration), CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 86, Pages: 875-885, ISSN: 1522-1946

Journal article

Bourantas CV, Serruys PW, Nakatani S, Zhang Y-J, Farooq V, Diletti R, Ligthart J, Sheehy A, van Geuns R-JM, McClean D, Chevalier B, Windecker S, Koolen J, Ormiston J, Whitbourn R, Rapoza R, Veldhof S, Onuma Y, Garcia-Garcia HMet al., 2015, Bioresorbable vascular scaffold treatment induces the formation of neointimal cap that seals the underlying plaque without compromising the luminal dimensions: a concept based on serial optical coherence tomography data, EUROINTERVENTION, Vol: 11, Pages: 746-756, ISSN: 1774-024X

Journal article

van Klaveren D, Vergouwe Y, Farooq V, Serruys PW, Steyerberg EWet al., 2015, Estimates of absolute treatment benefit for individual patients required careful modeling of statistical interactions, JOURNAL OF CLINICAL EPIDEMIOLOGY, Vol: 68, Pages: 1366-1374, ISSN: 0895-4356

Journal article

Byrne RA, Serruys PW, Baumbach A, Escaned J, Fajadet J, James S, Joner M, Oktay S, Jueni P, Kastrati A, Sianos G, Stefanini GG, Wijns W, Windecker Set al., 2015, Report of a European Society of Cardiology-European Association of Percutaneous Cardiovascular Interventions task force on the evaluation of coronary stents in Europe: executive summary, EUROPEAN HEART JOURNAL, Vol: 36, Pages: 2608-2620, ISSN: 0195-668X

Journal article

Campos CM, Fedewa RJ, Garcia-Garcia HM, Vince DG, Margolis MP, Lemos PA, Stone GW, Serruys PW, Nair Aet al., 2015, Ex vivo validation of 45 MHz intravascular ultrasound backscatter tissue characterization, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol: 16, Pages: 1112-1119, ISSN: 2047-2404

Journal article

Kelbaek H, Holmvang L, Richardt G, Eberli FR, Stella P, Buszman PE, Neumann F-J, Serruys PW, Windecker S, Widimsky P, Belardi JA, Silber Set al., 2015, Clinical results with the Resolute zotarolimus-eluting stent in total coronary occlusions, EUROINTERVENTION, Vol: 11, Pages: 650-657, ISSN: 1774-024X

Journal article

Genereux P, Campos CM, Yadav M, Palmerini T, Caixeta A, Xu K, Francese DP, Dangas GD, Mehran R, Leon MB, Serruys PW, Stone GWet al., 2015, Reasonable incomplete revascularisation after percutaneous coronary intervention: the SYNTAX Revascularisation Index, EUROINTERVENTION, Vol: 11, Pages: 634-642, ISSN: 1774-024X

Journal article

Moeckel M, Muller R, Searle J, Slagman A, De Bruyne B, Serruys P, Weisz G, Xu K, Holert F, Mueller C, Maehara A, Stone GWet al., 2015, Usefulness of Beta2-Microglobulin as a Predictor of All-Cause and Nonculprit Lesion-Related Cardiovascular Events in Acute Coronary Syndromes (from the PROSPECT Study), AMERICAN JOURNAL OF CARDIOLOGY, Vol: 116, Pages: 1034-1040, ISSN: 0002-9149

Journal article

Giustino G, Baber U, Stefanini GG, Aquino M, Stone GW, Sartori S, Steg PG, Wijns W, Smits PC, Jeger RV, Leon MB, Windecker S, Serruys PW, Morice M-C, Camenzind E, Weisz G, Kandzari D, Dangas GD, Mastoris I, Von Birgelen C, Galatius S, Kimura T, Mikhail G, Itchhaporia D, Mehta L, Ortega R, Kim H-S, Valgimigli M, Kastrati A, Chieffo A, Mehran Ret al., 2015, Impact of Clinical Presentation (Stable Angina Pectoris vs Unstable Angina Pectoris or Non-ST-Elevation Myocardial Infarction vs ST-Elevation Myocardial Infarction) on Long-Term Outcomes in Women Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 116, Pages: 845-852, ISSN: 0002-9149

Journal article

Onuma Y, Kimura T, Raeber L, Magro M, Girasis C, van Domburg R, Windecker S, Mitsudo K, Serruys PWet al., 2015, Differences in coronary risk factors, procedural characteristics, mortality and stent thrombosis between two all-comers percutaneous coronary intervention registries from Europe and Japan: a patient-level data analysis of the Bern-Rotterdam and j-Cypher registries, EUROINTERVENTION, Vol: 11, Pages: 533-540, ISSN: 1774-024X

Journal article

Muramatsu T, Grundeken MJ, Ishibashi Y, Nakatani S, Girasis C, Campos CM, Morel M-A, Jonker H, de Winter RJ, Wykrzykowska JJ, Garcia-Garcia HM, Leon MB, Serruys PW, Onuma Yet al., 2015, Comparison between two- and three-dimensional quantitative coronary angiography bifurcation analyses for the assessment of bifurcation lesions: A subanalysis of the TRYTON pivotal IDE coronary bifurcation trial, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 86, Pages: E140-E149, ISSN: 1522-1946

Journal article

Chevalier B, Wijns W, Silber S, Garcia E, Serra A, Paunovic D, Serruys Pet al., 2015, Five-year clinical outcome of the Nobori drug-eluting coronary stent system in the treatment of patients with coronary ariery disease: final results of the NOBORI 1 trial, EUROINTERVENTION, Vol: 11, Pages: 549-554, ISSN: 1774-024X

Journal article

Parasca CA, Head SJ, Mohr FW, Mack MJ, Morice M-C, Holmes DR, Feldman TE, Colombo A, Dawkins KD, Serruys PW, Kappetein APet al., 2015, The impact of a second arterial graft on 5-year outcomes after coronary artery bypass grafting in the Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery Trial and Registry, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 150, Pages: 597-+, ISSN: 0022-5223

Journal article

Michail M, Torii R, Crake T, Ozkor M, Garcia-Garcia HM, Tenekecioglu E, Onuma Y, Mathur A, Serruys PW, Bourantas CVet al., 2015, Local Hemodynamics An Innocent Bystander or a Critical Factor Regulating Neoatherosclerotic Evolution?, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 8, Pages: E149-E150, ISSN: 1936-8798

Journal article

Albuquerque FN, Bortnick A, Iqbal J, Ishibashi Y, Stone GW, Serruys PWet al., 2015, Dual antiplatelet therapy, drug-eluting stents and bioresorbable vascular scaffolds: Evolutionary perspectives, Catheterization and Cardiovascular Interventions, Vol: 87, Pages: 909-919, ISSN: 1522-726X

Dual antiplatelet therapy reduces the risk of myocardial infarction, stent thrombosis, and cardiovascular mortality after percutaneous coronary intervention, but the optimal duration of therapy remains unclear. Stent thrombosis, one of the most feared complications of coronary intervention, is associated with high mortality and morbidity and is related in part to technical and patient-specific factors. Advances in device technology and better understanding of the pathophysiology of stent thrombosis have reduced the frequency of this devastating complication. Bioresorbable vascular scaffolds possess a number of advantageous features and are currently undergoing active investigation. Bioresorbable vascular scaffolds have been demonstrated to restore physiologic vasomotion, allow for late lumen enlargement, and upon full resorption remove the nidus for very late polymer reactions and resolve concerns of stent malapposition and side branch jailing. Based on the results from recent large-scale randomized trials, the optimal duration of dual antiplatelet therapy may depend on the choice of device type, as well as the individual patient risk of ischemic versus hemorrhagic complications.

Journal article

Grundeken MJ, Kraak RP, De Winter RJ, Serruys PW, Wykrzykowska JJet al., 2015, How to define bifurcation lesion complexity and how to successfully perform percutaneous treatment, MINERVA CARDIOANGIOLOGICA, Vol: 63, Pages: 253-274, ISSN: 0026-4725

Journal article

Stanetic BM, Iqbal J, Onuma Y, Serruys PWet al., 2015, Novel bioresorbable scaffolds technologies: Current status and future directions, MINERVA CARDIOANGIOLOGICA, Vol: 63, Pages: 297-315, ISSN: 0026-4725

Journal article

Schultz CJ, Lauritsch G, Van Mieghem N, Rohkohl C, Serruys PW, van Geuns RJ, de Jaegere PPTet al., 2015, Rotational angiography with motion compensation: first-in-man use for the 30 evaluation of transcatheter valve prostheses, EUROINTERVENTION, Vol: 11, Pages: 442-449, ISSN: 1774-024X

Journal article

Papafaklis MI, Bourantas CV, Yonetsu T, Vergallo R, Kotsia A, Nakatani S, Lakkas LS, Athanasiou LS, Naka KK, Fotiadis DI, Feldman CL, Stone PH, Serruys PW, Jang I-K, Michalis LKet al., 2015, Anatomically correct three-dimensional coronary artery reconstruction using frequency domain optical coherence tomographic and angiographic data: head-to-head comparison with intravascular ultrasound for endothelial shear stress assessment in humans, EUROINTERVENTION, Vol: 11, Pages: 407-415, ISSN: 1774-024X

Journal article

Karanasos A, Schuurbiers JCH, Garcia-Garcia H, Simsek C, Onuma Y, Serruys PW, Zijlstra F, van Geuns R-J, Regar E, Wentzel JJet al., 2015, Association of wall shear stress with long-term vascular healing response following bioresorbable vascular scaffold implantation, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 191, Pages: 279-283, ISSN: 0167-5273

Journal article

Genereux P, Campos CM, Farooq V, Bourantas CV, Mohr FW, Colombo A, Morel M-A, Feldman TE, Holmes DR, Mack MJ, Morice M-C, Kappetein AP, Palmerini T, Stone GW, Serruys PWet al., 2015, Validation of the SYNTAX Revascularization Index to Quantify Reasonable Level of Incomplete Revascularization After Percutaneous Coronary Intervention, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 116, Pages: 174-186, ISSN: 0002-9149

Journal article

Serruys PW, 2015, A call for a new codified approach for experimentation in humans, EUROINTERVENTION, Vol: 11, Pages: 249-249, ISSN: 1774-024X

Journal article

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