Imperial College London

ProfessorPatrickSerruys

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

p.serruys

 
 
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Location

 

c/o Prof Kim FoxGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
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926 results found

Muramatsu T, García-García HM, Onuma Y, Zhang Y-J, Bourantas CV, Diletti R, Iqbal J, Radu MD, Ozaki Y, Serruys PW, on behalf of the TROFI investigatorset al., 2013, Intimal Flaps Detected by Optical Frequency Domain Imaging in the Proximal Segments of Native Coronary Arteries., Circ J

Background: The prevalence and clinical sequelae of optical frequency domain imaging (OFDI)-detected intimal flaps caused by vessel trauma or plaque rupture in the proximal native coronary arteries have not been described. Methods and Results: OFDI investigation was performed following stent implantation in patients with ST-segment elevation myocardial infarction (STEMI). We defined a flap-like structure (FS) as a disruption or discontinuation of the endoluminal vessel surface, and classified as actual flap or artifact. FS in the left main stem, or maximally 20mm distal to the guiding catheter in the proximal right coronary artery were assessed. A total of 8,931 frames in 97 patients were analyzed in a frame-by-frame fashion (0.125-mm interval). OFDI identified 8 FS in 7 patients, none of which was evident angiographically. All FS were left untreated because the operators per protocol were blinded to the OFDI images. A total of 5 FS in 5 patients (5.1%) appeared to be actual flaps in which only the intima was involved (mean distance from guiding catheter: 4.8±2.7mm). The remaining 3 FS in 3 patients were artifacts; namely, residual blood and interface light reflectivity. There were no adverse cardiac events during 6-months follow-up. Conclusions: In 5.1% of STEMI patients, post-procedural OFDI identified flaps with minimal involvement of the intima in the proximal coronary arteries. A precise interpretation of FS may help decision making to avoid unnecessary procedures. (Clinical Trial Registration Information: ClinicalTrials.gov identifier: NCT01271361.).

Journal article

Van Mieghem NM, Schipper MEI, Ladich E, Faqiri E, van der Boon R, Randjgari A, Schultz C, Moelker A, van Geuns R-J, Otsuka F, Serruys PW, Virmani R, de Jaegere PPet al., 2013, Histopathology of Embolic Debris Captured During Transcatheter Aortic Valve Replacement, CIRCULATION, Vol: 127, Pages: 2194-2201, ISSN: 0009-7322

Journal article

Iqbal J, Gunn J, Serruys PW, 2013, Coronary stents: historical development, current status and future directions, BRITISH MEDICAL BULLETIN, Vol: 106, Pages: 193-211, ISSN: 0007-1420

Journal article

Farooq V, van Klaveren D, Steyerberg EW, Serruys PWet al., 2013, SYNTAX score II - Authors' reply., Lancet, Vol: 381, Pages: 1899-1900

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Serruys PW, 2013, Cost-effectiveness: the menage a trois having a ratio with one denominator and one numerator, EUROINTERVENTION, Vol: 9, Pages: 173-173, ISSN: 1774-024X

Journal article

Muramatsu T, Onuma Y, Zhang Y-J, Bourantas CV, Kharlamov A, Diletti R, Farooq V, Gogas BD, Garg S, Garcia-Garcia HM, Ozaki Y, Serruys PWet al., 2013, Progress in Treatment by Percutaneous Coronary Intervention: The Stent of the Future, REVISTA ESPANOLA DE CARDIOLOGIA, Vol: 66, Pages: 483-496, ISSN: 0300-8932

Journal article

Bourantas CV, Garcia-Garcia HM, Diletti R, Muramatsu T, Serruys PWet al., 2013, Early detection and invasive passivation of future culprit lesions: A future potential or an unrealistic pursuit of Chimeras?, AMERICAN HEART JOURNAL, Vol: 165, Pages: 869-+, ISSN: 0002-8703

Journal article

Muramatsu T, Onuma Y, Zhang YJ, Bourantas CV, Kharlamov A, Diletti R, Farooq V, Gogas BD, Garg S, García-García HM, Ozaki Y, Serruys PWet al., 2013, Progress in treatment by percutaneous coronary intervention: the stent of the future., Rev Esp Cardiol (Engl Ed), Vol: 66, Pages: 483-496

First generation drug-eluting stents have considerably reduced in-stent restenosis and broadened the applications of percutaneous coronary interventions for the treatment of coronary artery disease. The polymer is an integral part of drug-eluting stents in that, it controls the release of an antiproliferative drug. The main safety concern of first generation drug-eluting stents with permanent polymers-stent thrombosis-has been caused by local hypersensitivity, delayed vessel healing, and endothelial dysfunction. This has prompted the development of newer generation drug-eluting stents with biodegradable polymers or even polymer-free drug-eluting stents. Recent clinical trials have shown the safety and efficacy of drug-eluting stents with biodegradable polymer, with proven reductions in very late stent thrombosis as compared to first generation drug-eluting stents. However, the concept of using a permanent metallic prosthesis implies major drawbacks, such as the presence of a foreign material within the native coronary artery that causes vascular inflammation and neoatherosclerosis, and also impedes the restoration of the vasomotor function of the stented segment. Bioresorbable scaffolds have been introduced to overcome these limitations, since they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. This update article presents the current status of these new technologies and highlights their future perspectives in interventional cardiology. Full English text available from:www.revespcardiol.org.

Journal article

Kharlamov AN, Duckers HJ, van Beusekom HMM, Smits PC, Perin EC, Serruys PWet al., 2013, Do we have a future with transcatheter adventitial delivery of stem cells?, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 165, Pages: 217-221, ISSN: 0167-5273

Journal article

Diletti R, Garcia-Garcia HM, Bourantas CV, van Geuns RJ, Van Mieghem NM, Agostoni P, Muramatsu T, Farooq V, Spencer R, De Schepper J, Pomeranz M, Stella P, Serruys PWet al., 2013, Clinical and angiographic outcomes following first-in-man implantation of a novel thin-strut low-profile fixed-wire stent: the Svelte Coronary Stent Integrated Delivery System first-in-man trial, EUROINTERVENTION, Vol: 9, Pages: 125-134, ISSN: 1774-024X

Journal article

Lemos PA, Farooq V, Takimura CK, Gutierrez PS, Vinnani R, Kolodgie F, Christians U, Kharlamov A, Doshi M, Sojitra P, van Beusekom HMM, Serruys PWet al., 2013, Emerging technologies: polymer-free phospholipid encapsulated sirolimus nanocarriers for the controlled release of drug from a stent-plus-balloon or a stand-alone balloon catheter, EUROINTERVENTION, Vol: 9, Pages: 148-156, ISSN: 1774-024X

Journal article

Serruys PW, 2013, The great iFR vs. FFR debate: why sometimes "the wait and see approach" is the best tactic as the best pragmatic solution will always emerge and become established, EUROINTERVENTION, Vol: 9, Pages: 11-+, ISSN: 1774-024X

Journal article

Piazza N, Kalesan B, van Mieghem N, Head S, Wenaweser P, Carrel TP, Bleiziffer S, de Jaegere PP, Gahl B, Anderson RH, Kappetein A-P, Lange R, Serruys PW, Windecker S, Jueni Pet al., 2013, A 3-Center Comparison of 1-Year Mortality Outcomes Between Transcatheter Aortic Valve Implantation and Surgical Aortic Valve Replacement on the Basis of Propensity Score Matching Among Intermediate-Risk Surgical Patients, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 6, Pages: 443-451, ISSN: 1936-8798

Journal article

MacHaalany J, Bilodeau L, Hoffmann R, Sack S, Sievert H, Kautzner J, Hehrlein C, Serruys P, Senechal M, Douglas P, Bertrand OFet al., 2013, Treatment of functional mitral valve regurgitation with the permanent percutaneous transvenous mitral annuloplasty system: Results of the multicenter international Percutaneous Transvenous Mitral Annuloplasty System to Reduce Mitral Valve Regurgitation in Patients with Heart Failure trial, AMERICAN HEART JOURNAL, Vol: 165, Pages: 761-769, ISSN: 0002-8703

Journal article

Dumonteil N, van der Boon RMA, Tchetche D, Chieffo A, Van Mieghem NM, Marcheix B, Buchanan GL, Vahdat O, Serruys PW, Fajadet J, Colombo A, de Jaegere PPT, Carrie Det al., 2013, Impact of preoperative chronic kidney disease on short- and long-term outcomes after transcatheter aortic valve implantation: A Pooled-RotterdAm-Milano-Toulouse In Collaboration Plus (PRAGMATIC-Plus) initiative substudy, AMERICAN HEART JOURNAL, Vol: 165, Pages: 752-760, ISSN: 0002-8703

Journal article

Farooq V, Vranckx P, Mauri L, Cutlip DE, Belardi J, Silber S, Widimsky P, Leon M, Windecker S, Meredith I, Negoita M, van Leeuwen F, Neumann F-J, Yeung AC, Garcia-Garcia HM, Serruys PWet al., 2013, Impact of overlapping newer generation drug-eluting stents on clinical and angiographic outcomes: pooled analysis of five trials from the international Global RESOLUTE Program, HEART, Vol: 99, Pages: 626-633, ISSN: 1355-6037

Journal article

Garg S, Bourantas C, Serruys PW, 2013, New concepts in the design of drug-eluting coronary stents, NATURE REVIEWS CARDIOLOGY, Vol: 10, Pages: 248-260, ISSN: 1759-5002

Journal article

Kappetein AP, Head SJ, Morice M-C, Banning AP, Serruys PW, Mohr F-W, Dawkins KD, Mack MJet al., 2013, Treatment of complex coronary artery disease in patients with diabetes: 5-year results comparing outcomes of bypass surgery and percutaneous coronary intervention in the SYNTAX trial, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 43, Pages: 1006-1013, ISSN: 1010-7940

Journal article

Farooq V, Serruys PW, Heo JH, Gogas BD, Onuma Y, Perkins LE, Diletti R, Radu MD, Räber L, Bourantas CV, Zhang Y, van Remortel E, Pawar R, Rapoza RJ, Powers JC, van Beusekom HMM, Garcìa-Garcìa HM, Virmani Ret al., 2013, Intracoronary optical coherence tomography and histology of overlapping everolimus-eluting bioresorbable vascular scaffolds in a porcine coronary artery model: the potential implications for clinical practice., JACC Cardiovasc Interv, Vol: 6, Pages: 523-532

OBJECTIVES: This study sought to assess the vascular response of overlapping Absorb stents compared with overlapping newer-generation everolimus-eluting metallic platform stents (Xience V [XV]) in a porcine coronary artery model. BACKGROUND: The everolimus-eluting bioresorbable vascular scaffold (Absorb) is a novel approach to treating coronary lesions. A persistent inflammatory response, fibrin deposition, and delayed endothelialization have been reported with overlapping first-generation drug-eluting stents. METHODS: Forty-one overlapping Absorb and overlapping Xience V (XV) devices (3.0 × 12 mm) were implanted in the main coronary arteries of 17 nonatherosclerotic pigs with 10% overstretch. Implanted coronary arteries were evaluated by optical coherence tomography (OCT) at 28 days (Absorb n = 11, XV n = 7) and 90 days (Absorb n = 11, XV n = 8), with immediate histological evaluation following euthanasia at the same time points. One animal from each time point was evaluated with scanning electron microscopy alone. A total of 1,407 cross sections were analyzed by OCT and 148 cross sections analyzed histologically. RESULTS: At 28 days in the overlap, OCT analyses indicated 80.1% of Absorb struts and 99.4% of XV struts to be covered (p < 0.0001), corresponding to histological observations of struts with cellular coverage of 75.4% and 99.6%, respectively (p < 0.001). Uncovered struts were almost exclusively related to the presence of "stacked" Absorb struts, that is, with a direct overlay configuration. At 90 days, overlapping Absorb and overlapping XV struts demonstrated >99% strut coverage by OCT and histology, with no evidence of a significant inflammatory process, and comparable % volume obstructions. CONCLUSIONS: In porcine coronary arteries implanted with overlapping Absorb or overlapping XV struts, strut coverage is delayed at 28 days in overlapping Absorb, dependent on the overlay configuration of the thicker Absorb struts. At 90 days

Journal article

Gogas BD, Muramatsu T, Garcia-Garcia HM, Bourantas CV, Holm NR, Thuesen L, Farooq V, Onuma Y, Serruys PWet al., 2013, In vivo three dimensional optical coherence tomography. A novel imaging modality to visualize the edge vascular response, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 164, Pages: E35-E37, ISSN: 0167-5273

Journal article

Serruys PW, Farooq V, 2013, Revascularization Strategies in Patients with Diabetes, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 368, Pages: 1454-1455, ISSN: 0028-4793

Journal article

Bourantas CV, Garcia-Garcia HM, Naka KK, Sakellarios A, Athanasiou L, Fotiadis DI, Michalis LK, Serruys PWet al., 2013, Hybrid Intravascular Imaging, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 61, Pages: 1369-1378, ISSN: 0735-1097

Journal article

Silber S, Serruys PW, Leon MB, Meredith IT, Windecker S, Neumann F-J, Belardi J, Widimsky P, Massaro J, Novack V, Yeung AC, Saito S, Mauri Let al., 2013, Clinical Outcome of Patients With and Without Diabetes Mellitus After Percutaneous Coronary Intervention With the Resolute Zotarolimus-Eluting Stent 2-Year Results From the Prospectively Pooled Analysis of the International Global RESOLUTE Program, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 6, Pages: 357-368, ISSN: 1936-8798

Journal article

Garg S, Bourantas C, Serruys PW, 2013, DES the year in review: controversies, MINERVA CARDIOANGIOLOGICA, Vol: 61, Pages: 99-123, ISSN: 0026-4725

Journal article

Onuma Y, Thuesen L, van Geuns R-J, van der Ent M, Desch S, Fajadet J, Christiansen E, Smits P, Holm NR, Regar E, van Mieghem N, Borovicanin V, Paunovic D, Senshu K, van Es G-A, Muramatsu T, Lee I-S, Schuler G, Zijlstra F, Garcia-Garcia HM, Serruys PWet al., 2013, Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study-TROFI trial, EUROPEAN HEART JOURNAL, Vol: 34, Pages: 1050-+, ISSN: 0195-668X

Journal article

Serruys PW, 2013, Travelling around the world with interventional cardiology, EUROINTERVENTION, Vol: 8, Pages: 1347-1347, ISSN: 1774-024X

Journal article

Girasis C, Schuurbiers JCH, Muramatsu T, Aben J-P, Onuma Y, Soekhradj S, Morel M-A, van Geuns R-J, Wentzel JJ, Serruys PWet al., 2013, Advanced three-dimensional quantitative coronary angiographic assessment of bifurcation lesions: methodology and phantom validation, EUROINTERVENTION, Vol: 8, Pages: 1451-1460, ISSN: 1774-024X

Journal article

Mack MJ, Head SJ, Holmes DR, Staehle E, Feldman TE, Colombo A, Morice M-C, Unger F, Erglis A, Stoler R, Dawkins KD, Serruys PW, Mohr FW, Kappetein APet al., 2013, Analysis of Stroke Occurring in the SYNTAX Trial Comparing Coronary Artery Bypass Surgery and Percutaneous Coronary Intervention in the Treatment of Complex Coronary Artery Disease, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 6, Pages: 344-354, ISSN: 1936-8798

Journal article

Farooq V, Gogas BD, Okamura T, Heo JH, Magro M, Gomez-Lara J, Onuma Y, Radu MD, Brugaletta S, van Bochove G, van Geuns RJ, Garcia-Garcia HM, Serruys PWet al., 2013, Three-dimensional optical frequency domain imaging in conventional percutaneous coronary intervention: the potential for clinical application, EUROPEAN HEART JOURNAL, Vol: 34, Pages: 875-885, ISSN: 0195-668X

Journal article

Genereux P, Head SJ, Hahn R, Daneault B, Kodali S, Williams MR, van Mieghem NM, Alu MC, Serruys PW, Kappetein AP, Leon MBet al., 2013, Paravalvular Leak After Transcatheter Aortic Valve Replacement The New Achilles' Heel? A Comprehensive Review of the Literature, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 61, Pages: 1125-1136, ISSN: 0735-1097

Journal article

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