Imperial College London

ProfessorPatrickSerruys

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

p.serruys

 
 
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Location

 

c/o Prof Kim FoxGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

926 results found

Muramatsu T, Onuma Y, Garcia-Garcia HM, Farooq V, Bourantas CV, Morel M-A, Li X, Veldhof S, Bartorelli A, Whitbourn R, Abizaid A, Serruys PWet al., 2013, Incidence and Short-Term Clinical Outcomes of Small Side Branch Occlusion After Implantation of an Everolimus-Eluting Bioresorbable Vascular Scaffold An Interim Report of 435 Patients in the ABSORB-EXTEND Single-Arm Trial in Comparison With an Everolimus-Eluting Metallic Stent in the SPIRIT First and II Trials, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 6, Pages: 247-257, ISSN: 1936-8798

Journal article

Gogas BD, Garcia-Garcia HM, Onuma Y, Muramatsu T, Farooq V, Bourantas CV, Serruys PWet al., 2013, Edge Vascular Response After Percutaneous Coronary Intervention An Intracoronary Ultrasound and Optical Coherence Tomography Appraisal: From Radioactive Platforms to First- and Second-Generation Drug-Eluting Stents and Bioresorbable Scaffolds, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 6, Pages: 211-221, ISSN: 1936-8798

Journal article

Papadopoulou S-L, Girasis C, Dharampal A, Farooq V, Onuma Y, Rossi A, Morel M-A, Krestin GP, Serruys PW, de Feyter PJ, Garcia HMGet al., 2013, CT-SYNTAX Score A Feasibility and Reproducibility Study, JACC-CARDIOVASCULAR IMAGING, Vol: 6, Pages: 413-415, ISSN: 1936-878X

Journal article

Serruys PW, 2013, On EEPs and e-blasts, cluster publishing, consensus and interventional cardiology, EUROINTERVENTION, Vol: 8, Pages: 1229-1229, ISSN: 1774-024X

Journal article

Magro M, Girasis C, Bartorelli AL, Tarantini G, Russo F, Trabattoni D, D'Amico G, Galli M, Gomez Juame A, Almeida MDS, Simsek C, Foley D, Sonck J, Lesiak M, Kayaert P, Serruys PW, van Geuns R-Jet al., 2013, Acute procedural and six-month clinical outcome in patients treated with a dedicated bifurcation stent for left main stem disease: the TRYTON LM multicentre registry, EUROINTERVENTION, Vol: 8, Pages: 1259-1269, ISSN: 1774-024X

Journal article

Farooq V, Girasis C, Magro M, Onuma Y, Morel MA, Heo JH, Garcia-Garcia H, Kappetein AP, van den Brand M, Holmes DR, Mack M, Feldman T, Colombo A, Stahle E, James S, Carrie D, Fournial G, van Es G-A, Dawkins KD, Mohr FW, Morice M-C, Serruys PWet al., 2013, The CABG SYNTAX Score - an angiographic tool to grade the complexity of coronary disease following coronary artery bypass graft surgery: from the SYNTAX Left Main Angiographic (SYNTAX-LE MANS) substudy, EUROINTERVENTION, Vol: 8, Pages: 1277-1285, ISSN: 1774-024X

Journal article

Chieffo A, Buchanan GL, Van Mieghem NM, Tchetche D, Dumonteil N, Latib A, van der Boon RMA, Vahdat O, Marcheix B, Farah B, Serruys PW, Fajadet J, Carrie D, de Jaegere PPT, Colombo Aet al., 2013, Transcatheter Aortic Valve Implantation With the Edwards SAPIEN Versus the Medtronic CoreValve Revalving System Devices A Multicenter Collaborative Study: The PRAGMATIC Plus Initiative (Pooled-RotterdAm-Milano-Toulouse In Collaboration), JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 61, Pages: 830-836, ISSN: 0735-1097

Journal article

Mohr FW, Morice M-C, Kappetein AP, Feldman TE, Stahle E, Colombo A, Mack MJ, Holmes DR, Morel M-A, Van Dyck N, Houle VM, Dawkins KD, Serruys PWet al., 2013, Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial, LANCET, Vol: 381, Pages: 629-638, ISSN: 0140-6736

Journal article

Farooq V, van Klaveren D, Steyerberg EW, Meliga E, Vergouwe Y, Chieffo A, Kappetein AP, Colombo A, Holmes DR, Mack M, Feldman T, Morice M-C, Stahle E, Onuma Y, Morel M-A, Garcia-Garcia HM, van Es GA, Dawkins KD, Mohr FW, Serruys PWet al., 2013, Anatomical and clinical characteristics to guide decision making between coronary artery bypass surgery and percutaneous coronary intervention for individual patients: development and validation of SYNTAX score II, LANCET, Vol: 381, Pages: 639-650, ISSN: 0140-6736

Journal article

Van Mieghem NM, Chieffo A, Dumonteil N, Tchetche D, van der Boon RMA, Buchanan GL, Marcheix B, Vahdat O, Serruys PW, Fajadet J, Carrie D, Colombo A, de Jaegere PPTet al., 2013, Trends in outcome after transfemoral transcatheter aortic valve implantation, AMERICAN HEART JOURNAL, Vol: 165, Pages: 183-192, ISSN: 0002-8703

Journal article

Garcia-Garcia HM, Schultz C, Duckers E, Regar E, Ligthart J, Serruys PW, van Geuns RJet al., 2013, Five-year follow-up of the ABSORB bioresorbable everolimuseluting vascular scaffold system: multimodality imaging assessment, EUROINTERVENTION, Vol: 8, Pages: 1226-1227, ISSN: 1774-024X

Journal article

Damen NL, Pelle AJ, Boersma E, Serruys PW, van Domburg RT, Pedersen SSet al., 2013, Reduced positive affect (anhedonia) is independently associated with 7-year mortality in patients treated with percutaneous coronary intervention: results from the RESEARCH registry, EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, Vol: 20, Pages: 127-134, ISSN: 2047-4873

Journal article

Garg S, Serruys PW, 2013, An update on drug-eluting stents., Curr Treat Options Cardiovasc Med, Vol: 15, Pages: 61-78, ISSN: 1092-8464

OPINION STATEMENT: Coronary artery disease remains one of the major causes of morbidity and mortality worldwide. Percutaneous coronary intervention has been shown to be an effective treatment for angina pectoris, although it does not provide any prognostic benefit in stable patients. Drug-eluting stents (DES) have revolutionised the practice of interventional cardiology by permitting the percutaneous treatment of increasingly complex coronary artery lesions, which historically would have only been treated with surgery. There have been concerns with their long-term safety; however, the most recent large meta-analysis appears to suggest that these concerns are no longer a pertinent issue with the newest generation of stents. Consequently, DES are being used in complex patients and lesion types, and clinical data and guideline recommendations support this. New stent designs are also continually being developed, with the aim to further improve the safety profile of these devices. It must, however, be kept in mind that complacency following the impressive result from initial DES studies lead to, amongst others things, sub-optimal and careless stent deployment, and inappropriate patient selection, which may have ultimately contributed to the prior safety concerns. It is vital, therefore, that this is not repeated in light of the reassuring data, or with newer devices. Finally, as stent design improves, it is becoming increasingly difficult to identify meaningful and clinically relevant differences in stent performance without the requirement of a very large, expensive, randomised trial.

Journal article

Farooq V, Serruys PW, Garcia-Garcia HM, Zhang Y, Bourantas CV, Holmes DR, Mack M, Feldman T, Morice M-C, Stahle E, James S, Colombo A, Diletti R, Papafaklis MI, de Vries T, Morel M-A, van Es GA, Mohr FW, Dawkins KD, Kappetein A-P, Sianos G, Boersma Eet al., 2013, The Negative Impact of Incomplete Angiographic Revascularization on Clinical Outcomes and Its Association With Total Occlusions, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 61, Pages: 282-294, ISSN: 0735-1097

Journal article

van der Boon RMA, Chieffo A, Dumonteil N, Tchetche D, Van Mieghem NM, Buchanan GL, Vandat O, Marcheix B, Serruys PW, Fajadet J, Colombo A, Carrie D, van Domburg RT, de Jaegere PPTet al., 2013, Effect of Body Mass Index on Short- and Long-Term Outcomes After Transcatheter Aortic Valve Implantation, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 111, Pages: 231-236, ISSN: 0002-9149

Journal article

Kappetein AP, Head SJ, Genereux P, Piazza N, van Mieghem NM, Blackstone EH, Brott TG, Cohen DJ, Cutlip DE, van Es G-A, Hahn RT, Kirtane AJ, Krucoff MW, Kodali S, Mack MJ, Mehran R, Rodes-Cabau J, Vranckx P, Webb JG, Windecker S, Serruys PW, Leon MBet al., 2013, Updated standardized endpoint definitions for transcatheter aortic valve implantation: The Valve Academic Research Consortium-2 consensus document, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 145, Pages: 6-23, ISSN: 0022-5223

Journal article

Brugaletta S, Garcia-Garcia HM, Gomez-Lara J, Radu MD, Pawar R, Khachabi J, Bruining N, Sabate M, Serruys PWet al., 2013, Reproducibility of qualitative assessment of stent struts coverage by optical coherence tomography, INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, Vol: 29, Pages: 5-11, ISSN: 1569-5794

Journal article

Serruys PW, 2013, The authors' challenge, EUROINTERVENTION, Vol: 8, Pages: 995-995, ISSN: 1774-024X

Journal article

Onuma Y, Miquel-Hebert K, Serruys PW, 2013, Five-year long-term clinical follow-up of the XIENCE V everolimus-eluting coronary stent system in the treatment of patients with de novo coronary artery disease: the SPIRIT II trial, EUROINTERVENTION, Vol: 8, Pages: 1047-1051, ISSN: 1774-024X

Journal article

Diletti R, Farooq V, Girasis C, Bourantas C, Onuma Y, Heo JH, Gogas BD, van Geuns R-J, Regar E, de Bruyne B, Dudek D, Thuesen L, Chevalier B, McClean D, Windecker S, Whitbourn RJ, Smits P, Koolen J, Meredith I, Li X, Miquel-Hebert K, Veldhof S, Garcia-Garcia HM, Ormiston JA, Serruys PWet al., 2013, Clinical and intravascular imaging outcomes at 1 and 2 years after implantation of absorb everolimus eluting bioresorbable vascular scaffolds in small vessels. Late lumen enlargement: does bioresorption matter with small vessel size? Insight from the ABSORB cohort B trial, HEART, Vol: 99, Pages: 98-105, ISSN: 1355-6037

Journal article

Vranckx P, McFadden E, Cutlip DE, Mehran R, Swart M, Kint PP, Zijlstra F, Silber S, Windecker S, Serruys PWCJet al., 2013, Clinical endpoint adjudication in a contemporary all-comers coronary stent investigation: methodology and external validation., Contemp Clin Trials, Vol: 34, Pages: 53-59

BACKGROUND: Globalisation in coronary stent research calls for harmonization of clinical endpoint definitions and event adjudication. Little has been published about the various processes used for event adjudication or their impact on outcome reporting. METHODS AND RESULTS: We performed a validation of the clinical event committee (CEC) adjudication process on 100 suspected events in the RESOLUTE All-comers trial (Resolute-AC). Two experienced Clinical Research Organisations (CRO) that had already extensive internal validation processes in place, participated in the study. After initial adjudication by the primary-CEC, events were cross-adjudicated by an external-CEC using the same definitions. Major discrepancies affecting the primary end point of target-lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction (TV-MI), or clinically-indicated target-lesion revascularization (CI-TLR), were analysed by an independent oversight committee who provided recommendations for harmonization. Discordant adjudications were reconsidered by the primary CEC. Subsequently, the RAC database was interrogated for cases that based on these recommendations merited re-adjudication and these cases were also re-adjudicated by the primary CEC. Final discrepancies in adjudication of individual components of TLF occurred in 7 out of 100 events in 5 patients. Discrepancies for the (hierarchical) primary endpoint occurred in 5 events (2 cardiac deaths and 3 TV-MI). After application of harmonization recommendations to the overall RAC population (n=2292), the primary CEC adjudicated 3 additional clinical-TLRs and considered 1 TV-MI as no event. CONCLUSIONS: A harmonization process provided a high level of concordance for event adjudication and improved accuracy for final event reporting. These findings suggest it is feasible to pool clinical event outcome data across clinical trials even when different CECs are responsible for event adjudication.

Journal article

Zhang Y, Bourantas CV, Farooq V, Muramatsu T, Diletti R, Onuma Y, Garcia-Garcia HM, Serruys PWet al., 2013, Bioresorbable scaffolds in the treatment of coronary artery disease., Med Devices (Auckl), Vol: 6, Pages: 37-48, ISSN: 1179-1470

Drug-eluting stents have reduced the risk of in-stent restenosis and have broadened the application in percutaneous coronary intervention in coronary artery disease. However, the concept of using a permanent metallic endovascular device to restore the patency of a stenotic artery has inherited pitfalls, namely the presence of a foreign body within the artery causing vascular inflammation, late complications such as restenosis and stent thrombosis, and impeding the restoration of the physiologic function of the stented segment. Bioresorbable scaffolds (BRS) were introduced to potentially overcome these limitations, as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. Currently, several BRSs are available, undergoing evaluation either in clinical trials or in preclinical settings. The aim of this review is to present the new developments in BRS technology, describe the mechanisms involved in the resorption process, and discuss the potential future prospects of this innovative therapy.

Journal article

Springeling T, Kirschbaum SW, Rossi A, Baks T, Karamermer Y, Schulz C, Ouhlous M, Duncker DJ, Moelker A, Krestin GP, Serruys PWJC, de Feyter P, van Geuns R-JMet al., 2013, Late cardiac remodeling after primary percutaneous coronary intervention-five-year cardiac magnetic resonance imaging follow-up., Circ J, Vol: 77, Pages: 81-88

BACKGROUND: Primary percutaneous coronary intervention (PPCI) preserves function and improves survival. The late effects of PPCI on left ventricular remodeling, however, have not yet been investigated on cardiac magnetic resonance imaging (CMRI). METHODS AND RESULTS: Twenty-five patients with acute myocardial infarction (AMI) treated with PPCI underwent CMRI within 10 days, at 4 months and at 5 years. Left ventricular ejection fraction (LVEF), end-diastolic volume (EDV) and end-systolic volume were quantified on cine images. Infarct mass and transmural extent of infarction were quantified on contrast-enhanced imaging. In all patients EDV increased significantly in the early phase (192 ± 40 ml to 211 ± 49 ml, P ≤ 0.01) and LVEF improved significantly (42 ± 9% to 46 ± 9%, P=0.02). In the late phase (>4 months) no significant changes were observed (LVEF 44 ± 9%, P=0.07; EDV 216 ± 68 ml, P=0.38). Three different groups could be identified. One-third (32%) had no dilatation at all; one-third (32%) had limited dilatation at 4 months without progression later; and 36% had progressive dilatation both at 4 months and at late follow-up. This third group had an average increase in EDV of 20% in the acute phase followed by an additional 13%. The strongest predictor for progressive dilatation was infarct mass. CONCLUSIONS: Even in the era of PPCI for AMI followed by optimal medical therapy, one-third of patients had progressive dilatation, which was best predicted by infarct mass.

Journal article

Ruiz-Garcia J, Lerman A, Weisz G, Maehara A, Mintz GS, Fahy M, Xu K, Lansky AJ, Cristea E, Farah TG, Teles R, Botker HE, Templin B, Zhang Z, de Bruyne B, Serruys PW, Stone GWet al., 2012, Age- and gender-related changes in plaque composition in patients with acute coronary syndrome: the PROSPECT study, EUROINTERVENTION, Vol: 8, Pages: 929-938, ISSN: 1774-024X

Journal article

Serruys PW, Cummins P, 2012, Peer reviewers - indispensable elements in the publishing universe, EUROINTERVENTION, Vol: 8, Pages: 879-+, ISSN: 1774-024X

Journal article

Diletti R, Serruys P, 2012, From first to second generation drug eluting stents for treatment of coronary bifurcations: Are we making progress?, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 80, Pages: 1171-1172, ISSN: 1522-1946

Journal article

Wykrzykowska JJ, Diletti R, Gutierrez-Chico JL, van Geuns RJ, van der Giessen WJ, Ramcharitar S, Duckers HE, Schultz C, de Feyter P, van der Ent M, Regar E, de Jaegere P, Garcia-Garcia HM, Pawar R, Gonzalo N, Ligthart J, de Schepper J, van den Berg N, Milewski K, Granada JF, Serruys PWet al., 2012, Plaque sealing and passivation with a mechanical self-expanding low outward force nitinol vShield device for the treatment of IVUS and OCT-derived thin cap fibroatheromas (TCFAs) in native coronary arteries: report of the pilot study vShield Evaluated at Cardiac hospital in Rotterdam for Investigation and Treatment of TCFA (SECRITT), EUROINTERVENTION, Vol: 8, Pages: 945-954, ISSN: 1774-024X

Journal article

Farooq V, Vergouwe Y, Raber L, Vranckx P, Garcia-Garcia H, Diletti R, Kappetein AP, Morel MA, de Vries T, Swart M, Valgimigli M, Dawkins KD, Windecker S, Steyerberg EW, Serruys PWet al., 2012, Combined anatomical and clinical factors for the long-term risk stratification of patients undergoing percutaneous coronary intervention: the Logistic Clinical SYNTAX score, EUROPEAN HEART JOURNAL, Vol: 33, Pages: 3098-+, ISSN: 0195-668X

Journal article

Muramatsu T, Garcia-Garcia HM, Lee IS, Bruining N, Onuma Y, Serruys PWet al., 2012, Quantitative Optical Frequency Domain Imaging Assessment of In-Stent Structures in Patients With ST-Segment Elevation Myocardial Infarction - Impact of Imaging Sampling Rate, CIRCULATION JOURNAL, Vol: 76, Pages: 2822-2831, ISSN: 1346-9843

Journal article

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