Imperial College London

ProfessorPatrickSerruys

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

p.serruys

 
 
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Location

 

c/o Prof Kim FoxGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

926 results found

Onuma Y, Serruys PW, Kukreja N, Veldhof S, Doostzadeh J, Cao S, Stone GWet al., 2010, Randomized comparison of everolimus- and paclitaxel-eluting stents: pooled analysis of the 2-year clinical follow-up from the SPIRIT II and III trials, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 1071-1078, ISSN: 0195-668X

Journal article

Sarno G, Onuma Y, Garcia HMG, Garg S, Regar E, Thuesen L, Dudek D, Veldhof S, Dorange C, Ormiston JA, Serruys PWet al., 2010, IVUS Radiofrequency Analysis in the Evaluation of the Polymeric Struts of the Bioabsorbable Everolimus-Eluting Device During the Bioabsorption Process, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 75, Pages: 914-918, ISSN: 1522-1946

Journal article

Garg S, Duckers HJ, Serruys PW, 2010, Endothelial progenitor cell capture stents: will this technology find its niche in contemporary practice?, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 1032-1035, ISSN: 0195-668X

Journal article

Magro M, Schultz C, Simsek C, Garcia-Garcia HM, Regar E, Nieman K, Mollet N, Serruys PW, van Geuns R-Jet al., 2010, Computed tomography as a tool for percutaneous coronary intervention of chronic total occlusions., EuroIntervention, Vol: 6 Suppl G, Pages: G123-G131

Chronic total occlusions (CTO) constitute a major challenge in percutaneous coronary revascularisation (PCI). The development of new interventional strategies, the availability of purpose made tools including dedicated catheters and wires, as well as increasing expertise by the operators, have contributed to the modest success rates which today hover around 75%. Case selection is of utmost importance since failure of this high risk procedure with its typically high radiation doses, high contrast doses and increased complication rates is associated with long term adverse events. Imaging of the coronary arteries using the gold standard of invasive coronary angiography allows characterisation of the chronic total occlusion and is often able to predict the probability of successful recanalisation. Multislice computed tomography (MSCT) is increasingly being utilised as a non-invasive diagnostic imaging modality to detect coronary artery disease. Its ability to provide information on the soft tissue (including plaque) surrounding the lumen has been applied to better define the morphological features of CTOs. In fact, the amount of calcification, tortuosity and actual length of the occluded segment which are established predictors of success, are all better characterised by MSCT. Three dimensional reconstruction of the coronary anatomy and its integration with two dimensional fluoroscopy images during the actual CTO-PCI procedure may help to identify the best angiographic projection, offering a directional guide at the angiographically "missing segment". More technological advances are needed to optimise this multi-modality imaging integration. Whether this will result in better success rates for CTO-PCI is still the subject of ongoing research. It is then that we can evaluate the true benefit of the use of MSCT for CTO against the risk from excessive radiation associated with this strategy.

Journal article

Serruys PW, 2010, EuroIntervention, a bright light., EuroIntervention, Vol: 6, Pages: 11-13

Journal article

Garg S, Schultz C, Sarno G, Serruys PWet al., 2010, How should I treat a tortuous calcified right coronary artery?, EuroIntervention, Vol: 6, Pages: 161-167

Journal article

Schultz CJ, Moelker AD, Tzikas A, Rossi A, van Geuns R-J, de Feyter PJ, Serruys PWet al., 2010, Cardiac CT: necessary for precise sizing for transcatheter aortic implantation., EuroIntervention, Vol: 6 Suppl G, Pages: G6-G13

Sizing for transcutaneous aortic valve replacement (TAVI) relies on non-invasive imaging. Incorrect sizing may result in adverse outcomes including paraprosthetic regurgitation, asymmetrical expansion which may impair prosthesis durability and, in the case of severe sizing errors, device embolisation or aortic root rupture. This review addresses the optimal approach for sizing. It is based on currently available data including the anatomical implications of using different imaging modalities, the steps of how to reproducibly measure the correct annulus diameter on MSCT, and current evidence for different sizing strategies.

Journal article

Regar E, van Soest G, Bruining N, Constantinescu AA, van Geuns RJ, van der Giessen W, Serruys PWet al., 2010, Optical coherence tomography in patients with acute coronary syndrome., EuroIntervention, Vol: 6 Suppl G, Pages: G154-G160

Optical coherence tomography (OCT) is a novel invasive imaging technology that allows in vivo assessment of the coronary wall with high resolution (approximately 15 micron). OCT offers a number of specific diagnostic features to study culprit lesions in patients suffering from acute coronary syndrome (ACS). Clinical OCT studies in patients presenting with ACS were able to confirm post mortem histopathology findings and shed light on the dynamic nature of atherosclerotic plaque formation, modification and rupture. OCT confirmed in vivo that the incidence of target lesion and remote TCFA varies with the clinical syndrome of the patients, being most pronounced in patients with acute myocardial infarction as compared to patients with stable angina. In culprit lesions where rupture of a fibrous cap has been documented, the fibrous cap thickness was in the range of 50 micron and macrophage density was elevated. Encouraging small scale clinical studies evaluated treatment effects in this population. OCT was used to demonstrate statin effects on fibrous cap thickness or the effects of different stent designs. The markedly improved image quality and user-friendliness of the second generation, Fourier-domain OCT, will allow large scale clinical application and thus, will increase our understanding of the pathophysiology and the prevention of ACS.

Journal article

van Domburg RT, Daemen J, Morice M-C, de Bruyne B, Colombo A, Macaya C, Richardt G, Fajadet J, Hamm C, van Es G-A, Wittebols K, Macours N, Stoll HP, Serruys PWet al., 2010, Short- and long-term health related quality-of-life and anginal status of the Arterial Revascularisation Therapies Study part II, ARTS-II; sirolimus-eluting stents for the treatment of patients with multivessel coronary artery disease, EUROINTERVENTION, Vol: 5, Pages: 962-967, ISSN: 1774-024X

Journal article

Bruining N, de Winter S, Roelandt JRTC, Regar E, Heller I, van Domburg RT, Hamers R, Onuma Y, Dudek D, Webster MWI, Thuesen L, Ormiston JA, Cheong W-F, Miguel-Hebert K, Veldhof S, Serruys PWet al., 2010, Monitoring In Vivo Absorption of a Drug-Eluting Bioabsorbable Stent With Intravascular Ultrasound-Derived Parameters A Feasibility Study, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 3, Pages: 449-456, ISSN: 1936-8798

Journal article

Garg S, Serruys PW, 2010, Drug-eluting stents: a reappraisal, HEART, Vol: 96, Pages: 489-493, ISSN: 1355-6037

Journal article

Shin E-S, Garcia-Garcia HM, Serruys PW, 2010, A new method to measure necrotic core and calcium content in coronary plaques using intravascular ultrasound radiofrequency-based analysis, INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, Vol: 26, Pages: 387-396, ISSN: 1569-5794

Journal article

Schultz CJ, Moelker A, Piazza N, Tzikas A, Otten A, Nuis RJ, Neefjes LA, van Geuns RJ, de Feyter P, Krestin G, Serruys PW, de Jaegere PPTet al., 2010, Three dimensional evaluation of the aortic annulus using multislice computer tomography: are manufacturer's guidelines for sizing for percutaneous aortic valve replacement helpful?, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 849-856, ISSN: 0195-668X

Journal article

Kirschbaum SW, Springeling T, Boersma E, Moelker A, van der Giessen WJ, Serruys PW, de Feyter PJ, van Geuns R-JMet al., 2010, Complete Percutaneous Revascularization for Multivessel Disease in Patients With Impaired Left Ventricular Function, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 3, Pages: 392-400, ISSN: 1936-8798

Journal article

Okamura T, Garg S, Gutierrez-Chico JL, Shin E-S, Onuma Y, Garcia-Garcia HM, Rapoza RJ, Sudhir K, Regar E, Serruys PWet al., 2010, In vivo evaluation of stent strut distribution patterns in the bioabsorbable everolimus-eluting device: an OCT ad hoc analysis of the revision 1.0 and revision 1.1 stent design in the ABSORB clinical trial, EUROINTERVENTION, Vol: 5, Pages: 932-938, ISSN: 1774-024X

Journal article

Serruys PW, Onuma Y, Garg S, Vranckx P, De Bruyne B, Morice M-C, Colombo A, Macaya C, Richardt G, Fajadet J, Hamm C, Schuijer M, Rademaker T, Wittebols K, Stoll HPet al., 2010, 5-Year Clinical Outcomes of the ARTS II (Arterial Revascularization Therapies Study II) of the Sirolimus-Eluting Stent in the Treatment of Patients With Multivessel De Novo Coronary Artery Lesions, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 55, Pages: 1093-1101, ISSN: 0735-1097

Journal article

Gerstein HC, Ratner RE, Cannon CP, Serruys PW, Garcia-Garcia HM, van Es G-A, Kolatkar NS, Kravitz BG, Miller DM, Huang C, Fitzgerald PJ, Nesto RWet al., 2010, Effect of Rosiglitazone on Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease, CIRCULATION, Vol: 121, Pages: 1176-1187, ISSN: 0009-7322

Journal article

Banning AP, Westaby S, Morice M-C, Kappetein AP, Mohr FW, Berti S, Glauber M, Kellett MA, Kramer RS, Leadley K, Dawkins KD, Serruys PWet al., 2010, Diabetic and Nondiabetic Patients With Left Main and/or 3-Vessel Coronary Artery Disease Comparison of Outcomes With Cardiac Surgery and Paclitaxel-Eluting Stents, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 55, Pages: 1067-1075, ISSN: 0735-1097

Journal article

Schenkeveld L, Pedersen SS, van Nierop JWI, Lenzen MJ, de Jaegere PPT, Serruys PW, van Domburg RTet al., 2010, Health-related quality of life and long-term mortality in patients treated with percutaneous coronary intervention, AMERICAN HEART JOURNAL, Vol: 159, Pages: 471-476, ISSN: 0002-8703

Journal article

Okamura T, Serruys PW, Regar E, 2010, Three-dimensional visualization of intracoronary thrombus during stent implantation using the second generation, Fourier domain optical coherence tomography, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 625-625, ISSN: 0195-668X

Journal article

Hekkert MTL, Dube GP, Regar E, de Boer M, Vranckx P, van der Giessen WJ, Serruys PW, Duncker DJet al., 2010, Preoxygenated hemoglobin-based oxygen carrier HBOC-201 annihilates myocardial ischemia during brief coronary artery occlusion in pigs, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 298, Pages: H1103-H1113, ISSN: 0363-6135

Journal article

Garg S, Serruys P, 2010, Benefits of and safety concerns associated with drug-eluting coronary stents., Expert Rev Cardiovasc Ther, Vol: 8, Pages: 449-470

Drug-eluting coronary stents are being used with increasing frequency in patients undergoing percutaneous coronary intervention. Although these stents have shown remarkably low rates of restenosis compared with their predecessors, there have been increasing concerns lately regarding their safety. Extensive data have been published that demonstrate a higher risk of very late stent thrombosis with drug-eluting stents; however, this has not had any impact on long-term mortality or the risk of myocardial infarction when compared with bare-metal stents. Their overall net clinical benefit therefore still favors their use. Recent research has led to a greater understanding of the multifactorial cause of stent thrombosis, which has enabled measures to be taken to reduce an individual patient's risk. In the future, new stent designs and new antiplatelet agents may help to reduce this risk further.

Journal article

Sarno G, Garg S, Onuma Y, Buszman P, Linke A, Ischinger T, Klauss V, Eberli F, Corti R, Wijns W, Morice M-C, di Mario C, van Geuns RJ, Eerdmans P, Garcia-Garcia HM, van Es G-A, Goedhart D, de Vries T, Jueni P, Meier B, Windecker S, Serruys Pet al., 2010, The Impact of Body Mass Index on the One Year Outcomes of Patients Treated by Percutaneous Coronary Intervention With Biolimus- and Sirolimus-Eluting Stents (from the LEADERS Trial), AMERICAN JOURNAL OF CARDIOLOGY, Vol: 105, Pages: 475-479, ISSN: 0002-9149

Journal article

Vranckx P, Cutlip DE, Mehran R, Kint P-P, Silber S, Windecker S, Serruys PWet al., 2010, Myocardial infarction adjudication in contemporary all-comer stent trials: balancing sensitivity and specificity. Addendum to the historical MI definitions used in stent studies, EUROINTERVENTION, Vol: 5, Pages: 871-874, ISSN: 1774-024X

Journal article

Piazza N, Wenaweser P, van Gameren M, Pilgrim T, Tsikas A, Otten A, Nuis R, Onuma Y, Cheng JM, Kappetein AP, Boersma E, Juni P, de Jaegere P, Windecker S, Serruys PWet al., 2010, Relationship between the logistic EuroSCORE and the Society of Thoracic Surgeons Predicted Risk of Mortality score in patients implanted with the CoreValve ReValving System-A Bern-Rotterdam Study, AMERICAN HEART JOURNAL, Vol: 159, ISSN: 0002-8703

Journal article

Kubo T, Maehara A, Mintz GS, Garcia-Garcia HM, Serruys PW, Suzuki T, Klauss V, Sumitsuji S, Lerman A, Marso SP, Margolis MP, Margolis JR, Foster MC, De Bruyne B, Leon MB, Stone GWet al., 2010, Analysis of the long-term effects of drug-eluting stents on coronary arterial wall morphology as assessed by virtual histology intravascular ultrasound, AMERICAN HEART JOURNAL, Vol: 159, ISSN: 0002-8703

Journal article

Seth A, Serruys PW, Lansky A, Hermiller J, Onuma Y, Miquel-Hebert K, Yu S, Veldhof S, Sood P, Sudhir K, Stone GWet al., 2010, A pooled gender based analysis comparing the XIENCE V (R) everolimus-eluting stent and the TAXUS paclitaxel-eluting stent in male and female patients with coronary artery disease, results of the SPIRIT II and SPIRIT III studies: two-year analysis, EUROINTERVENTION, Vol: 5, Pages: 788-794, ISSN: 1774-024X

Journal article

Prati F, Regar E, Mintz GS, Arbustini E, Di Mario C, Jang I-K, Akasaka T, Costa M, Guagliumi G, Grube E, Ozaki Y, Pinto F, Serruys PWJet al., 2010, Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 401-415, ISSN: 0195-668X

Journal article

Serruys PW, 2010, AsiaPCR/SingLIVE, a new evolution, among others for the PCR community, EUROINTERVENTION, Vol: 5, Pages: 759-759, ISSN: 1774-024X

Journal article

Caliskan K, Balk AHHM, Wykrzykowska JJ, van Geuns R-J, Serruys PWet al., 2010, How should I treat an unusual referral for heart transplantation?, EuroIntervention, Vol: 5, Pages: 861-865

BACKGROUND: A 55 years old man was referred for cardiac transplantation because of intractable angina and fatigue. INVESTIGATION: Physical examination, laboratory test, echocardiography, exercise ECG, MRI and coronary arteriography. DIAGNOSIS: Multiple coronary artery fistulae. MANAGEMENT: Beta-blockers, angiotensin-converting enzyme inhibitor ICD.

Journal article

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