Imperial College London

ProfessorPatrickSerruys

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

p.serruys

 
 
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Location

 

c/o Prof Kim FoxGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

926 results found

Ratner RE, Cannon CP, Gerstein HC, Nesto RW, Serruys PW, van Es G-A, Kolatkar NS, Kravitz BG, Zalewski A, Fitzgerald PJet al., 2008, Assessment on the Prevention of Progression by Rosiglitazone on Atherosclerosis in diabetes patients with Cardiovascular History (APPROACH): Study design and baseline characteristics, AMERICAN HEART JOURNAL, Vol: 156, Pages: 1074-1079, ISSN: 0002-8703

Journal article

Gonzalo N, Garcia-Garcia HM, Ligthart J, Rodriguez-Granillo G, Meliga E, Onuma Y, Schuurbiers JCH, Bruining N, Serruys PWet al., 2008, Coronary plaque composition as assessed by greyscale intravascular ultrasound and radiofrequency spectral data analysis, INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, Vol: 24, Pages: 811-818, ISSN: 1569-5794

Journal article

Ramcharitar S, Meliga E, Kirschbaum SW, ten Cate FJ, van Geuns RJ, Serruys PWet al., 2008, Acute hemodynamic changes in percutaneous transluminal septal coil embolization for hypertrophic obstructive cardiomyopathy, NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, Vol: 5, Pages: 806-810, ISSN: 1743-4297

Journal article

Ramcharitar S, van Geuns RJ, Patterson M, van der Giessen WJ, van der Ent M, van Domburg RT, Serruys PWet al., 2008, A Randomized Comparison of the Magnetic Navigation System Versus Conventional Percutaneous Coronary Intervention, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 72, Pages: 761-770, ISSN: 1522-1946

Journal article

Tanimoto S, Bruining N, van Domburg RT, Rotger D, Radeva P, Ligthart JM, Serruys PWet al., 2008, Late Stent Recoil of the Bioabsorbable Everolimus-Eluting Coronary Stent and its Relationship With Plaque Morphology, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 52, Pages: 1616-1620, ISSN: 0735-1097

Journal article

Mercado N, Brugts JJ, Ix JH, Shlipak MG, Dixon SR, Gersh BJ, Lemos PA, Guarneri M, Teirstein PS, Wijns W, Serruys PW, Boersma E, O'Neill WWet al., 2008, Usefulness of Proteinuria as a Prognostic Marker of Mortality and Cardiovascular Events Among Patients Undergoing Percutaneous Coronary Intervention (Data from the Evaluation of Oral Xemilofiban in Controlling Thrombotic Events [EXCITE] Trial), AMERICAN JOURNAL OF CARDIOLOGY, Vol: 102, Pages: 1151-1155, ISSN: 0002-9149

Journal article

Segers D, Garcia-Garcia HM, Cheng C, de Crom R, Krams R, Wentzel JJ, van der Steen AFW, Serruys PW, Leenen PJM, Laman JDet al., 2008, A primer on the immune system in the pathogenesis and treatment of atherosclerosis., EuroIntervention, Vol: 4, Pages: 378-390, ISSN: 1774-024X

Atherosclerosis is currently appreciated as a disease with a large inflammatory component. The underlying mechanisms, which are uncovered in a rapid pace, are greatly interconnected and as such very complex. Nevertheless, for clinicians it is important have some degree of insight in these immunologic mechanisms in order to interpret the current research advances. The aim of this review is to supply clinicians with this knowledge, avoiding too much detail. All the relevant immunologic basics will be discussed at first, followed by the immunity related theories of atherosclerosis. Finally, current and new immune-modulatory therapies will be discussed.

Journal article

Vranckx P, Meliga E, De Jaegere PPT, Van den Ent M, Regar ES, Serruys PWet al., 2008, The TandemHeart, percutaneous transseptal left ventricular assist device: a safeguard in high-risk percutaneous coronary interventions. The six-year Rotterdam experience., EuroIntervention, Vol: 4, Pages: 331-337, ISSN: 1774-024X

AIMS: Percutaneous coronary interventions (PCI) in high-risk cardiac patients are preferentially referred to specialised myocardial intervention centres (MIC). Included in this group are patients with a haemodynamic collapse or high likelihood of haemodynamic collapse, either during balloon inflation or with acute vessel closure. The TandemHeart, a percutaneous transseptal left ventricular assist (PTVA) that can be introduced using standard catheterisation laboratory techniques, offers interesting perspectives to reduce procedural risks. METHODS AND RESULTS: Between September 2000 to July 2006, The TandemHeart, supported the circulation of 23 patients (age: range 46-74, mean 59) admitted to our centre for high risk, either emergency or elective, PCI. Successful implantation was achieved in 100% of patients. The mean time for implementation of circulatory support was 35 minutes (range 16-62). The index PCI was successful in all patients except two. A pump flow up to 4L/min was achieved with significant reduction of left ventricular filling pressures, pulmonary capillary wedge pressure and with significant increase of systemic arterial pressures. Duration of support ranged from 1-222 hours (mean 31+/-49.8 hours). Five patients died with the TandemHeart in place, four of whom were in irreversible cardiogenic shock at admission. Mild to moderate access site bleeding was seen in 27% of patients. One patient experienced a loge syndrome of the leg. Core temperature (Ct) decreased to <36.5 degrees C in six patients, profound hypothermia (Ct <35 degrees C) was observed in two patients. There was no technical device failure. CONCLUSIONS: The TandemHeart - PTVA provides effective, total left ventricular support in very high risk PCI settings. The rate of device related cardiac and vascular complications was acceptable.

Journal article

van Twisk P-H, Daemen J, Kukreja N, van Domburg RT, Serruys PWet al., 2008, Four-year safety and efficacy of the unrestricted use of sirolimus- and paclitaxel-eluting stents in coronary artery bypass grafts., EuroIntervention, Vol: 4, Pages: 311-317, ISSN: 1774-024X

OBJECTIVES: Recently, concerns were raised about the relative long-term safety and efficacy of drug-eluting stents (DES) in saphenous vein bypass grafts (SVG). Our objective was to assess the 4-year relative safety and efficacy of the unrestricted use of drug-eluting stents (DES) as compared to bare metal stents (BMS) in saphenous vein bypass grafts (SVG). METHODS: Between April 16, 2002 and December 2005 a total of 122 consecutive patients were treated with either sirolimus- or paclitaxel-eluting stents for saphenous vein graft disease. These patients were compared with 128 consecutive patients treated with BMS in the immediate preceding period (January 1, 2000 to April 2002). RESULTS: At 4-years the cumulative survival rate in the DES group was 77.5% versus 73.0% in the BMS group (adjusted HR 1.09; 95% CI 0.63-1.90, Logrank p=0.65). The cumulative survival free of major adverse cardiac events (MACE: death, myocardial infarction and target vessel revascularisation) was 61.5% vs. 46.8% in the DES and BMS groups respectively (adjusted HR 0.77, 95% CI; 0.51-1.16) due to a higher event free survival of clinically driven target vessel revascularisation in the DES group as compared to the BMS group (81.6% vs. 69.0%; adjusted HR 0.53; 95% CI 0.27-1.05). CONCLUSIONS: In the present study, the use of DES for SVG PCI was associated a similar safety profile and there was a trend towards lower rates of TVR and MACE at four years as compared to BMS.

Journal article

De Jaegere PPT, Piazza N, Galema TW, Otten A, Soliman OI, Van Dalen BM, Geleijnse ML, Kappetein A-P, Garcia HMG, Van Es G-A, Serruys PWet al., 2008, Early echocardiographic evaluation following percutaneous implantation with the self-expanding CoreValve Revalving System aortic valve bioprosthesis., EuroIntervention, Vol: 4, Pages: 351-357, ISSN: 1774-024X

AIMS: Although safety and feasibility studies have been published, there are few reports dedicated to the echocardiographic evaluation of patients following percutaneous aortic valve replacement (PAVR). This report describes the early echocardiographic evaluation of patients undergoing PAVR with the CoreValve Revalving System. METHODS AND RESULTS: The population consisted of 33 consecutive patients with aortic stenosis who underwent successful PAVR. Echocardiograms were performed pre-treatment (123+/-110 days prior), post-treatment (6+/-2 days) and post-discharge (80+/-64 days). Aortic valve function and left ventricular dimensions, systolic and diastolic function were assessed pre- and post-implantation. The mean age was 81+/-7 years and the mean Logistic Euroscore was 20+/-12. Following PAVR, the mean transaortic valve gradient decreased (46+/-16 mmHg pre-treatment vs. 12+/-7 mmHg post-treatment vs. 9+/-5 mmHg post-discharge, p<0.001) and the mean effective orifice area increased (0.75+/-0.23 cm2 pre-treatment vs. 1.97+/-0.85 cm2 post-treatment vs. 1.72+/-0.45 cm2 post-discharge, p<0.001). There was no significant change in mean ejection fraction (41+/-12% pre-treatment vs. 46+/-15% post-treatment vs. 44+/-13% post-discharge, p=0.44). Approximately two-thirds of patients had no change in diastolic function at follow-up. CONCLUSION: Following implantation, there was a sustained decrease in aortic valve gradient and increase in aortic valve area. In addition, the mean ejection fraction did not change significantly and in the majority of patients, diastolic function was unchanged.

Journal article

Serruys PW, 2008, Together, we can truly insure the future., EuroIntervention, Vol: 4, ISSN: 1774-024X

Journal article

Tsuchida K, Daemen J, Tanimoto S, Garcia-Garcia HM, Kukreja N, Vaina S, Ong ATL, Sianos G, de Jaegere PPT, van Domburg RT, Serruys PWet al., 2008, Two-year outcome of the use of paclitaxel-eluting stents in aorto-ostial lesions, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 129, Pages: 348-353, ISSN: 0167-5273

Journal article

Serruys PW, Windecker S, Buszman P, Linke A, Ischinger T, Klauss V, Eberli F, Wijns W, Morice M-C, Di Mario Cet al., 2008, Leaders - A Randomized Comparison Of A Biolimus-A9 Eluting Stent With A Sirolimus-eluting Stent For Percutaneous Coronary Intervention. 12 Months Results, 20th Annual Transcatheter Cardiovascular Therapeutics Conference, Publisher: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, Pages: 160I-161I, ISSN: 0002-9149

Conference paper

Barlis P, Regar E, Dimopoulos K, van der Giessen WJ, van Geuns R, van den Ent M, Sianos G, Gonzalo N, Devries A, Ligthart J, de Feyter P, Ferrante G, Davies SW, Foran J, Collinson J, Leatham E, Clague J, Serruys PW, di Mario Cet al., 2008, A Randomized Optical Coherence Tomography Study of an Erodible versus Durable Polymer-Coated Limus-Eluting Stent, 20th Annual Transcatheter Cardiovascular Therapeutics Conference, Publisher: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, Pages: 15I-15I, ISSN: 0002-9149

Conference paper

Steendijk P, Meliga E, Valgimigli M, Ten Cate FJ, Serruys PWet al., 2008, Acute effects of alcohol septal ablation on systolic and diastolic left ventricular function in patients with hypertrophic obstructive cardiomyopathy, HEART, Vol: 94, Pages: 1318-1322, ISSN: 1355-6037

Journal article

Gijsen FJH, Wentzel JJ, Thury A, Mastik F, Schaar JA, Schuurbiers JCH, Slager CJ, van der Giessen WJ, de Feyter PJ, van der Steen AFW, Serruys PWet al., 2008, Strain distribution over plaques in human coronary arteries relates to shear stress, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 295, Pages: H1608-H1614, ISSN: 0363-6135

Journal article

Kukreja N, Onuma Y, Garcia-Garcia H, Daemen J, van Domburg R, Serruys PWet al., 2008, Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction Long-Term Outcome After Bare Metal and Drug-Eluting Stent Implantation, CIRCULATION-CARDIOVASCULAR INTERVENTIONS, Vol: 1, Pages: 103-110, ISSN: 1941-7640

Journal article

Garcia-Garcia HM, Gonzalo N, Tanimoto S, Meliga E, de Jaegere P, Serruys PWet al., 2008, Characterization of edge effects with paclitaxel-eluting stents using serial intravascular ultrasound radiofrequency data analysis: The BETAX (BEside TAXus) study, REVISTA ESPANOLA DE CARDIOLOGIA, Vol: 61, Pages: 1013-1019, ISSN: 0300-8932

Journal article

Wiemer M, Seth A, Chandra P, Neuzner J, Richardt G, Piek JJ, Desaga M, Macaya C, Bol CJ, Miquel-Hebert K, De Roeck K, Serruys PWet al., 2008, Systemic exposure of everolimus after stent implantation: a pharmacokinetic study., Am Heart J, Vol: 156, Pages: 751.e1-751.e7

OBJECTIVES: We evaluated the pharmacokinetics of the eluted everolimus by assessing systemic drug release and distribution of everolimus-eluting stents. BACKGROUND: Drugs eluted by a coronary stent might cause adverse events such as tumors, infections, or noncardiac death. The systemic exposure of the drugs is unknown because there are only limited data about pharmacokinetics of drug-eluting stents in humans. METHODS: Venous blood samples in a subset of 39 patients were drawn just before implantation of the first stent (baseline, 0-minute time point) and at 10 and 30 minutes and 1, 2, 4, 6, 12, 24, 36, 48, 72, 168, and 720 hours (30 days) after completion of implantation of the last stent. Whole blood concentrations of everolimus were determined using a sensitive validated high-performance liquid chromatography mass spectrometry/mass spectrometry method. RESULTS: The total dose of everolimus received by the patients ranged from 53 to 588 microg. The last time point up to which whole blood concentrations could be quantified ranged per patient from 4 to 720 hours after implantation of the last stent. Across all dose levels, individual T(max) values ranged from 0.13 and 2.17 hours; individual C(max) ranged from 0.14 to 2.79 ng/mL. CONCLUSION: This study confirms the limited exposure to the systemic circulation of the eluted drug with the use of the XIENCE V Everolimus-Eluting Coronary Stent System (Abbott Vascular, Santa Clara, CA). Therefore, a systemic cause of adverse events is unlikely.

Journal article

Gonzalo N, Serruys PW, Regar E, 2008, Optical coherence tomography: clinical applications and the evaluation of DES., Minerva Cardioangiol, Vol: 56, Pages: 511-525, ISSN: 0026-4725

Optical coherencet tomography (OCT) is a light-based imaging modality that can provide in vivo high-resolution images of the coronary artery. In the last years there has been a continuous technical development that has improved the image quality and has simplified the acquisition procedure in order to spread the clinical applicability of this technique. Due to its high resolution OCT, can be a very valuable tool for the evaluation of the coronary vessel wall, the acute and long-term impact of catheter-based intervention on plaque structure and vessel architecture and the assessment of stents. During stenting, OCT offers the possibility to evaluate stent apposition in great detail and can identify the presence of vessel injury due to stent implantation. At follow-up, the tissue coverage of individual struts can be imaged with OCT. This is of increasing interest in drug-eluting stents in which the neointimal proliferation is inhibited to such extent that it might not be visualized with conventional intracoronary imaging techniques such as IVUS. Regarding the analysis of the coronary vessel wall, OCT holds promise for the identification of thin cap fibroatheroma due to its ability to provide information about plaque composition, presence of macrophages and thickness of the fibrous cap.

Journal article

Wenaweser P, Daemen J, Zwahlen M, van Domburg R, Jueni P, Vaina S, Hellige G, Tsuchida K, Morger C, Boersma E, Kukreja N, Meier B, Serruys PW, Windecker Set al., 2008, Incidence and correlates of drug-eluting stent thrombosis in routine clinical practice - 4-year results from a large 2-institutional cohort study, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 52, Pages: 1134-1140, ISSN: 0735-1097

Journal article

Serruys PW, Garcia-Garcia HM, Buszman P, Erne P, Verheye S, Aschermann M, Duckers H, Bleie O, Dudek D, Botker HE, von Birgelen C, D'Amico D, Hutchinson T, Zambanini A, Mastik F, van Es G-A, van der Steen AFW, Vince DG, Ganz P, Hamm CW, Wijns W, Zalewski Aet al., 2008, Effects of the direct lipoprotein-associated phospholipase A(2) inhibitor darapladib on human coronary atherosclerotic plaque, CIRCULATION, Vol: 118, Pages: 1172-1182, ISSN: 0009-7322

Journal article

Daemen J, Boersma E, Flather M, Booth J, Stables R, Rodriguez A, Rodriguez-Granillo G, Hueb WA, Lemos PA, Serruys PWet al., 2008, Long-term safety and efficacy of percutaneous coronary intervention with stenting and coronary artery bypass surgery for multivessel coronary artery disease - A meta-analysis with 5-year patient-level data from the ARTS, ERACI-II, MASS-II, and SoS trials, CIRCULATION, Vol: 118, Pages: 1146-1154, ISSN: 0009-7322

Journal article

Rivero-Ayerza M, Jessurun E, Ramcharitar S, van Belle Y, Serruys PW, Jordaens Let al., 2008, Magnetically guided left ventricular lead implantation based on a virtual three-dimensional reconstructed image of the coronary sinus, EUROPACE, Vol: 10, Pages: 1042-1047, ISSN: 1099-5129

Journal article

Barlis P, Ramcharitar S, Redwood S, Tan HC, Dimopoulos K, Sianos G, O'kane P, Regar E, Serruys PW, Di Mario Cet al., 2008, Long-term outcomes of bifurcation stenting using the culotte technique with drug-eluting stents, EUROPEAN HEART JOURNAL, Vol: 29, Pages: 631-632, ISSN: 0195-668X

Journal article

Chieffo A, Park S-J, Meliga E, Sheiban I, Lee MS, Latib A, Kim Y-H, Valgimigli M, Sillano D, Magni V, Biondi-Zoccai G, Montorfano M, Airoldi F, Rogacka R, Carlino M, Michev I, Lee C-W, Hong M-K, Park S-W, Moretti C, Bonizzoni E, Sangiorgi GM, Tobis J, Serruys PW, Colombo Aet al., 2008, Late and very late stent thrombosis following drug-eluting stent implantation in unprotected left main coronary artery: a multicentre registry, EUROPEAN HEART JOURNAL, Vol: 29, Pages: 2108-2115, ISSN: 0195-668X

Journal article

Windecker S, Serruys PW, Wandel S, Buszman P, Trznadel S, Linke A, Lenk K, Ischinger T, Klauss V, Eberli F, Corti R, Wijns W, Morice MC, di Mario C, Davies S, van Geuns R-J, Eerdmans P, van Es G-A, Meier B, Jueni Pet al., 2008, Biolimus-eluting stent with biodegradable polymer versus sirolimus-eluting stent with durable polymer for coronary revascularisation (LEADERS): a randomised non-inferiority trial, LANCET, Vol: 372, Pages: 1163-1173, ISSN: 0140-6736

Journal article

Meijboom WB, Van Mieghem CAG, van Pelt N, Weustink A, Pugliese F, Mollet NR, Boersma E, Regar E, van Geuns RJ, de Jaegere PJ, Serruys PW, Krestin GP, de Feyter PJet al., 2008, Comprehensive assessment of coronary artery stenoses - Computed tomography coronary angiography versus conventional coronary angiography and correlation with fractional flow reserve in patients with stable angina, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 52, Pages: 636-643, ISSN: 0735-1097

Journal article

Barlis P, Serruys PW, Gonzalo N, van der Giessen WJ, de Jaegere PJ, Regar Eet al., 2008, Assessment of culprit and remote coronary narrowings using optical coherence tomography with long-term outcomes, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 102, Pages: 391-395, ISSN: 0002-9149

Journal article

Meliga E, Valgimigli M, Buszman P, Serruys PWet al., 2008, Percutaneous coronary intervention or coronary artery bypass graft for unprotected left main coronary artery disease: The endless debate, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 52, Pages: 582-584, ISSN: 0735-1097

Journal article

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