Imperial College London

ProfessorPatrickSerruys

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

p.serruys

 
 
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Location

 

c/o Prof Kim FoxGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

926 results found

Chiastra C, Grundeken M, Wu W, Serruys P, de Winter R, Dubini G, Wykrzykowska J, Migliavacca Fet al., 2015, First report on free expansion simulations of a dedicated bifurcation stent mounted on a stepped balloon, EUROINTERVENTION, Vol: 10, ISSN: 1774-024X

Journal article

Sonneveld MAH, Cheng JM, Oemrawsingh RM, de Maat MPM, Kardys I, Garcia-Garcia HM, van Geuns R-J, Regar E, Serruys PW, Boersma E, Akkerhuis KM, Leebeek FWGet al., 2015, Von Willebrand factor in relation to coronary plaque characteristics and cardiovascular outcome Results of the ATHEROREMO-IVUS study, THROMBOSIS AND HAEMOSTASIS, Vol: 113, Pages: 577-584, ISSN: 0340-6245

Journal article

Ishibashi Y, Grundeken MJ, Nakatani S, Iqbal J, Morel M-A, Genereux P, Girasis C, Wentzel JJ, Garcia-Garcia HM, Onuma Y, Serruys PWet al., 2015, In Vitro Validation and Comparison of Different Software Packages or Algorithms for Coronary Bifurcation Analysis Using Calibrated Phantoms: Implications for Clinical Practice and Research of Bifurcation Stenting, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 85, Pages: 554-563, ISSN: 1522-1946

Journal article

Nakatani S, Ishibashi Y, Suwannasom P, Grundeken MJ, Christiansen EH, Onuma Y, Serruys PWet al., 2015, Development and Receding of a Coronary Artery Aneurysm After Implantation of a Fully Bioresorbable Scaffold, CIRCULATION, Vol: 131, Pages: 764-767, ISSN: 0009-7322

Journal article

Raeber L, Taniwaki M, Zaugg S, Kelbaek H, Roffi M, Holmvang L, Noble S, Pedrazzini G, Moschovitis A, Luescher TF, Matter CM, Serruys P, Jueni P, Garcia-Garcia HM, Windecker Set al., 2015, Effect of high-intensity statin therapy on atherosclerosis in non-infarct-related coronary arteries (IBIS-4): a serial intravascular ultrasonography study, EUROPEAN HEART JOURNAL, Vol: 36, Pages: 490-500, ISSN: 0195-668X

Journal article

Genereux P, Kumsars I, Lesiak M, Kini A, Fontos G, Slagboom T, Ungi I, Metzger DC, Wykrzykowska JJ, Stella PR, Bartorelli AL, Fearon WF, Lefevre T, Feldman RL, LaSalle L, Francese DP, Onuma Y, Grundeken MJ, Garcia-Garcia HM, Laak LL, Cutlip DE, Kaplan AV, Serruys PW, Leon MBet al., 2015, A Randomized Trial of a Dedicated Bifurcation Stent Versus Provisional Stenting in the Treatment of Coronary Bifurcation Lesions, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 65, Pages: 533-543, ISSN: 0735-1097

Journal article

Zhang Y-J, Iqbal J, Windecker S, Linke A, Antoni D, Sohn HY, Corti R, van Es G-A, Copt S, Eerdmans P, Saitta R, Morice M-C, Di Mario C, Juni P, Wijns W, Buszman P, Serruys PWet al., 2015, Biolimus-eluting stent with biodegradable polymer improves clinical outcomes in patients with acute myocardial infarction, HEART, Vol: 101, Pages: 271-278, ISSN: 1355-6037

Journal article

Iqbal J, Serruys PW, Albuquerque FN, Wijns Wet al., 2015, The year in cardiology 2014: coronary intervention, EUROPEAN HEART JOURNAL, Vol: 36, Pages: 347-+, ISSN: 0195-668X

Journal article

Damen NL, Versteeg H, Serruys PW, van Geuns R-JM, van Domburg RT, Pedersen SS, Boersma Eet al., 2015, Cardiac patients who completed a longitudinal psychosocial study had a different clinical and psychosocial baseline profile than patients who dropped out prematurely, EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, Vol: 22, Pages: 196-199, ISSN: 2047-4873

Journal article

Bourantas CV, Zhang Y-J, Garg S, Mack M, Dawkins KD, Kappetein AP, Mohr FW, Colombo A, Holmes DR, Stahle E, Feldman T, Morice M-C, de Vries T, Morel M-A, Serruys PWet al., 2015, Prognostic Implications of Severe Coronary Calcification in Patients Undergoing Coronary Artery Bypass Surgery: An Analysis of the SYNTAX Study, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 85, Pages: 199-206, ISSN: 1522-1946

Journal article

Mushtaq S, Goncalves PDA, Garcia-Garcia HM, Pontone G, Bartorelli AL, Bertella E, Campos CM, Pepi M, Serruys PW, Andreini Det al., 2015, Long-Term Prognostic Effect of Coronary Atherosclerotic Burden Validation of the Computed Tomography-Leaman Score, CIRCULATION-CARDIOVASCULAR IMAGING, Vol: 8, ISSN: 1941-9651

Journal article

Mahfoud F, Serruys PW, 2015, Renal denervation reloaded: where to go from here?, EUROINTERVENTION, Vol: 10, Pages: 1135-1137, ISSN: 1774-024X

Journal article

Grundeken MJ, Ishibashi Y, Genereux P, LaSalle L, Iqbal J, Wykrzykowska JJ, Morel M-A, Tijssen JG, de Winter RJ, Girasis C, Garcia-Garcia HM, Onuma Y, Leon MB, Serruys PWet al., 2015, Inter-Core Lab Variability in Analyzing Quantitative Coronary Angiography for Bifurcation Lesions A Post-Hoc Analysis of a Randomized Trial, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 8, Pages: 305-314, ISSN: 1936-8798

Journal article

Serruys PW, 2015, Evolutions and reflections on returning from AsiaPCR/SingLIVE 2015, EuroIntervention, Vol: 10, Pages: 1133-1133, ISSN: 1774-024X

Journal article

Campos CM, Ishibashi Y, Eggermont J, Nakatani S, Cho YK, Dijkstra J, Reiber JHC, Sheehy A, Lane J, Kamberi M, Rapoza R, Perkins L, Garcia-Garcia HM, Onuma Y, Serruys PWet al., 2015, Echogenicity as a surrogate for bioresorbable everolimus-eluting scaffold degradation: analysis at 1-, 3-, 6-, 12- 18, 24-, 30-, 36- and 42-month follow-up in a porcine model, International Journal of Cardiovascular Imaging, Vol: 31, Pages: 471-482, ISSN: 1875-8312

The objective of the study is to validate intravascular quantitative echogenicity as a surrogate for molecular weight assessment of poly-l-lactide-acid (PLLA) bioresorbable scaffold (Absorb BVS, Abbott Vascular, Santa Clara, California). We analyzed at 9 time points (from 1- to 42-month follow-up) a population of 40 pigs that received 97 Absorb scaffolds. The treated regions were analyzed by echogenicity using adventitia as reference, and were categorized as more (hyperechogenic or upperechogenic) or less bright (hypoechogenic) than the reference. The volumes of echogenicity categories were correlated with the measurements of molecular weight (Mw) by gel permeation chromatography. Scaffold struts appeared as high echogenic structures. The quantification of grey level intensity in the scaffold-vessel compartment had strong correlation with the scaffold Mw: hyperechogenicity (correlation coefficient = 0.75; P < 0.01), upperechogenicity (correlation coefficient = 0.63; P < 0.01) and hyper + upperechogenicity (correlation coefficient = 0.78; P < 0.01). In the linear regression, the R2 for high echogenicity and Mw was 0.57 for the combination of hyper and upper echogenicity. IVUS high intensity grey level quantification is correlated to Absorb BVS residual molecular weight and can be used as a surrogate for the monitoring of the degradation of semi-crystalline polymers scaffolds.

Journal article

Ielasi A, Brugaletta S, Silvestro A, Cequier A, Iniguez A, Serra A, Hernandez-Antolin R, Mainar V, Valgimigli M, den Heijer P, Bethencourt A, Vazquez N, Serruys P, Sabate M, Tespili Met al., 2015, Everolimus-eluting stent versus bare-metal stent in elderly (>= 75 years) versus non-elderly (<75 years) patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: Insights from the examination trial, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 179, Pages: 73-78, ISSN: 0167-5273

Journal article

Serruys PW, Chevalier B, Dudek D, Cequier A, Carrie D, Iniguez A, Dominici M, van der Schaaf RJ, Haude M, Wasungu L, Veldhof S, Peng L, Staehr P, Grundeken MJ, Ishibashi Y, Garcia-Garcia HM, Onuma Yet al., 2015, A bioresorbable everolimus-eluting scaffold versus a metallic everolimus-eluting stent for ischaemic heart disease caused by de-novo native coronary artery lesions (ABSORB II): an interim 1-year analysis of clinical and procedural secondary outcomes from a randomised controlled trial, LANCET, Vol: 385, Pages: 43-54, ISSN: 0140-6736

Journal article

Brugaletta S, Gori T, Low AF, Tousek P, Pinar E, Gomez-Lara J, Scalone G, Schulz E, Chan MY, Kocka V, Hurtado J, Gomez-Hospital JA, Muenzel T, Lee C-H, Cequier A, Valdes M, Widimsky P, Serruys PW, Sabate Met al., 2015, Absorb Bioresorbable Vascular Scaffold Versus Everolimus-Eluting Metallic Stent in ST-Segment Elevation Myocardial Infarction: 1-Year Results of a Propensity Score Matching Comparison The BVS-EXAMINATION Study (Bioresorbable Vascular Scaffold-A Clinical Evaluation of Everolimus Eluting Coronary Stents in the Treatment of Patients With ST-segment Elevation Myocardial Infarction), JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 8, Pages: 189-197, ISSN: 1936-8798

Journal article

Muramatsu T, Garcia-Garcia HM, Brugaletta S, Heo JH, Onuma Y, Fedewa RJ, Nair A, Ozaki Y, Serruys PWet al., 2015, Reproducibility of intravascular ultrasound radiofrequency data analysis (virtual histology) with a 45-MHz rotational imaging catheter in ex vivo human coronary arteries, JOURNAL OF CARDIOLOGY, Vol: 65, Pages: 134-142, ISSN: 0914-5087

Journal article

Campos CM, Suwannasom P, Koenig W, Serruys PW, Garcia-Garcia HMet al., 2015, Darapladib for the treatment of cardiovascular disease, EXPERT REVIEW OF CARDIOVASCULAR THERAPY, Vol: 13, Pages: 33-48, ISSN: 1477-9072

Journal article

van Boven N, Windecker S, Umans VA, van Domburg RT, Kardys I, Akkerhuis KM, van Geuns R-J, Serruys PW, Magro M, Raeber L, Boersma Eet al., 2015, Stent thrombosis in early-generation drug-eluting stents versus newer-generation everolimus-eluting stent assorted by LVEF, HEART, Vol: 101, Pages: 50-57, ISSN: 1355-6037

Journal article

Marti V, Brugaletta S, Garcia-Picart J, Delgado G, Cequier A, Iniguez A, Hernandez-Antolin R, Serruys P, Serra A, Sabate Met al., 2015, Radial Versus Femoral Access for Angioplasty of ST-segment Elevation Acute Myocardial Infarction With Second-generation Drug-eluting Stents, REVISTA ESPANOLA DE CARDIOLOGIA, Vol: 68, Pages: 47-53, ISSN: 0300-8932

Journal article

Serruys PW, 2015, Positioning consensus for guidance, EUROINTERVENTION, Vol: 10, Pages: 1013-1014, ISSN: 1774-024X

Journal article

Fox J, Hossainy S, Rapoza R, Serruys PWet al., 2015, Technology limitations of BRS in bifurcations., EuroIntervention, Vol: 11 Suppl V, Pages: V155-V158

Recommended techniques for bifurcation stenting continue to be revised with specific attention to bioresorbable scaffolds (BRS). Optimal procedural success and long-term outcomes with BRS can perhaps be improved with careful attention to implantation techniques. Good vessel preparation is imperative for optimal expansion of the scaffold, and proper vessel sizing is necessary to ensure compliance with scaffold expansion limits and preservation of proper scaffold function. The European Bifurcation Club (EBC) recommends provisional stenting for the majority of bifurcation lesions: permanent metallic stents are sized according to the distal vessel diameter, with subsequent post-dilatation of the proximal vessel to ensure stent apposition in the proximal main vessel. Recent BRS-specific modifications to the EBC recommendation suggest that selecting the scaffold size based on the diameter of the proximal main vessel can mitigate the risk of overexpansion and potential strut fracture. Expansion of the BRS requires a thoughtful balance between the risk of malapposition associated with underdeployment and the risk of strut fracture due to overdeployment. Post-dilatation of scaffolds should be performed, always respecting the maximum expansion limit, to correct any potential scaffold malapposition and minimise flow disturbances. Finally, dual antiplatelet therapy plays an important role in BRS bifurcation treatment to avoid thromboembolic events.

Journal article

Grundeken MJ, Généreux P, Wykrzykowska JJ, Leon MB, Serruys PWet al., 2015, The Tryton Side Branch Stent., EuroIntervention, Vol: 11 Suppl V, Pages: V145-V146

Journal article

Grundeken MJ, Magro M, Gil R, Briguori C, Sardella G, Berland J, Wykrzykowska JJ, Serruys PWet al., 2015, Dedicated stents for distal left main stenting., EuroIntervention, Vol: 11 Suppl V, Pages: V129-V134

Left main (LM) coronary bifurcation lesions have different anatomic features from non-LM bifurcation lesions. Dedicated bifurcation devices might facilitate percutaneous coronary intervention (PCI) of LM bifurcations and improve procedural and clinical outcomes. In this review we will discuss the available clinical data on dedicated bifurcation devices for the treatment of LM bifurcation lesions. Furthermore, we will try to discuss all the theoretical advantages and potential drawbacks of these devices in terms of their use in the LM.

Journal article

Campos CM, Christiansen EH, Stone GW, Serruys PWet al., 2015, The EXCEL and NOBLE trials: similarities, contrasts and future perspectives for left main revascularisation., EuroIntervention, Vol: 11 Suppl V, Pages: V115-V119

Unprotected left main coronary artery (ULMCA) stenosis has relatively high prevalence and exposes patients to a high risk for adverse cardiovascular events. The optimal revascularisation strategy (coronary artery bypass surgery [CABG] or percutaneous coronary intervention [PCI]) for patients with complex coronary artery disease is a topic of continuing debate. The introduction of the newer-generation drug-eluting stents (DES) -with documented improvements in both safety and efficacy- has prompted the interventional community to design two new dedicated randomised trials comparing CABG and PCI: the NOBLE (Coronary Artery Bypass Grafting Vs Drug Eluting Stent Percutaneous Coronary Angioplasty in the Treatment of Unprotected Left Main Stenosis) and EXCEL (Evaluation of XIENCE Everolimus Eluting Stent Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) trials. The aims of the present review are to describe the similarities and contrasts between these two trials as well to explore their future implications in ULMCA treatment.

Journal article

Onuma Y, Okamura T, Muramatsu T, Uemura S, Serruys PWet al., 2015, New implication of three-dimensional optical coherence tomography in optimising bifurcation PCI., EuroIntervention, Vol: 11 Suppl V, Pages: V71-V74

With the advance of optical coherence tomography (OCT) technology, three-dimensional (3D) reconstruction based on the optical coherence tomography has become feasible. In bifurcation lesions, 3D OCT may guide positioning of the wire through the appropriate (distal) cells. The early studies suggested that such a guidance strategy could reduce the incidence of malapposition in bifurcation lesions. The pre-installed "real-time" 3D OCT on the console will promote the utilisation of 3D assessment in bifurcation treatment and possibly establish the clinical benefit of such guidance in the near future when investigated in a prospective study.

Journal article

Serruys PW, 2015, The treatment of coronary bifurcations: a true art form., EuroIntervention, Vol: 11 Suppl V

Journal article

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