Imperial College London

ProfessorPatrickSerruys

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

p.serruys

 
 
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Location

 

c/o Prof Kim FoxGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

926 results found

Onuma Y, Muramatsu T, Girasis C, Kukreja N, Garcia-Garcia HM, Daemen J, Gonzalo N, Piazza N, Einthoven J, van Domburg R, Serruys PWet al., 2013, Single-vessel or multivessel PCI in patients with multivessel disease presenting with non-ST-elevation acute coronary syndromes, EUROINTERVENTION, Vol: 9, Pages: 916-922, ISSN: 1774-024X

Journal article

Serruys PW, 2013, Reflections on STEMI, EUROINTERVENTION, Vol: 9, Pages: 893-893, ISSN: 1774-024X

Journal article

Rodriguez-Granillo GA, Rodriguez AE, Bruining N, Milei J, Aoki J, Tsuchida K, del Valle-Fernandez R, Arampatzis CA, Ong ATL, Lemos PA, Ayala F, Garcia-Garcia HM, Saia F, Valgimigli M, Regar E, McFadden E, Biondi-Zoccai G, Barbenza E, Schoenhagen P, Serruys PWet al., 2013, Quantification of scientific output in cardiovascular medicine: a perspective based on global data, EUROINTERVENTION, Vol: 9, Pages: 975-978, ISSN: 1774-024X

Journal article

Bourantas CV, Garcia-Garcia HM, Farooq V, Maehara A, Xu K, Genereux P, Diletti R, Muramatsu T, Fahy M, Weisz G, Stone GW, Serruys PWet al., 2013, Clinical and Angiographic Characteristics of Patients Likely to Have Vulnerable Plaques, JACC-CARDIOVASCULAR IMAGING, Vol: 6, Pages: 1263-1272, ISSN: 1936-878X

Journal article

Farooq V, Girasis C, Magro M, Onuma Y, Morel M-A, Heo JH, Garcia-Garcia HM, Kappetein AP, van den Brand M, Holmes DR, Mack M, Feldman T, Colombo A, Stahle E, James S, Carrie D, Fournial G, van Es GA, Dawkins KD, Mohr FW, Morice M-C, Serruys PWet al., 2013, The coronary artery bypass graft SYNTAX Score: final five-year outcomes from the SYNTAX-LE MANS left main angiographic substudy, EUROINTERVENTION, Vol: 9, Pages: 1009-1010, ISSN: 1774-024X

Journal article

Girasis C, Farooq V, Diletti R, Muramatsu T, Bourantas CV, Onuma Y, Holmes DR, Feldman TE, Morel M-A, van Es G-A, Dawkins KD, Morice M-C, Serruys PWet al., 2013, Impact of 3-Dimensional Bifurcation Angle on 5-Year Outcome of Patients After Percutaneous Coronary Intervention for Left Main Coronary Artery Disease A Substudy of the SYNTAX Trial (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery), JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 6, Pages: 1250-1260, ISSN: 1936-8798

Journal article

Head SJ, Kaul S, Tijssen JGP, Serruys PW, Kappetein APet al., 2013, Subgroup Analyses in Trial Reports Comparing Percutaneous Coronary Intervention With Coronary Artery Bypass Surgery, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 310, Pages: 2097-2098, ISSN: 0098-7484

Journal article

de Boer SPM, van Leeuwen MAH, Cheng JM, Oemrawsingh RM, van Geuns R-J, Serruys PWJC, Boersma E, Lenzen MJet al., 2013, Trial participation as a determinant of clinical outcome: differences between trial-participants and Every Day Clinical Care patients in the field of interventional cardiology., Int J Cardiol, Vol: 169, Pages: 305-310

BACKGROUND: This study examines differences in clinical outcome between trial-participants and non-participants after percutaneous coronary intervention (PCI). METHODS AND RESULTS: This study compromised of 11,931 consecutive patients who underwent PCI in a high volume center, during the period 2000 - 2009. Of these patients, 1787 (15%) participated in an interventional clinical trial with a follow-up period of at least six months. The maximum follow-up duration was 11.8 years, with a median of 3.8 years (IQR: 2.6 - 6.5). Baseline and procedural characteristics differed between trial-participants and non-participants. Trial-participants were more often male, were younger, had more cardiovascular risk factors and were treated more often for stable angina pectoris and single vessel disease. Overall mortality at maximum follow-up was lower for trial-participants compared to non-participants (8.1% versus 17.6%, p<0.001, adjusted HR, 0.62, 95% CI: 0.52-0.74). There was no difference in the incidence of non-fatal MI and CABG. Repeat PCI was seen more often in trial-participants (18.1% versus 30.7%, p<0.001, adjusted HR 1.91, 95%CI 1.73-2.10). Consequently, a higher incidence of the composite of mortality, repeat revascularization, and non-fatal MI was seen in the trail-participants (adjusted HR.1.36 95% CI 1.25 - 1.47), but this association was primarily driven by the occurrence of repeat PCI. CONCLUSION: Participants in clinical trials in the field of interventional cardiology with a follow-up of at least six months differed considerably from non-participants in baseline and procedural characteristics. Trial-participants had better survival than non-participants. In contrast, a two-fold higher incidence of repeat PCI was observed in trial-participants.

Journal article

Nieman K, Serruys PW, Onuma Y, van Geuns R-J, Garcia-Garcia HM, de Bruyne B, Thuesen L, Smits PC, Koolen JJ, McClean D, Chevalier B, Meredith I, Ormiston Jet al., 2013, Multislice Computed Tomography Angiography for Noninvasive Assessment of the 18-Month Performance of a Novel Radiolucent Bioresorbable Vascular Scaffolding Device, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 62, Pages: 1813-1814, ISSN: 0735-1097

Journal article

Zhang Y-J, Garcia-Garcia HM, Farooq V, Bourantas CV, Serruys PW, Chen S-Let al., 2013, Revisiting: "Comparison of intravascular ultrasound versus angiography-guided drug-eluting stent implantation: a meta-analysis of one randomised trial and ten observational studies involving 19,619 patients", EUROINTERVENTION, Vol: 9, Pages: 891-892, ISSN: 1774-024X

Journal article

Meliga E, De Benedictis M, Chieffo A, Latib A, Park SJ, Kim YH, Onuma Y, Capranzano P, Jegere S, Makkar R, Palacios I, Buszman P, Bande M, Chakravarty T, Mehran R, Naber C, Scrocca I, Margey R, Leon M, Moses J, Fajadet J, Lefevre T, Morice MC, Erglis A, Tamburinos C, Alfieri O, Conte MR, Serruys PW, Colombo Aet al., 2013, Coronary artery bypass graft versus percutaneous coronary intervention with drug-eluting stent implantation for diabetic patients with unprotected left main coronary artery disease: the D-DELTA registry, EUROINTERVENTION, Vol: 9, Pages: 803-808, ISSN: 1774-024X

Journal article

Serruys PW, 2013, Asia rising, EUROINTERVENTION, Vol: 9, Pages: 775-775, ISSN: 1774-024X

Journal article

Yla-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen S, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PWJC, Waltenberger J, Weber C, Tokgozoglu Let al., 2013, Stabilization of atherosclerotic plaques: an update, EUROPEAN HEART JOURNAL, Vol: 34, Pages: 3251-3258, ISSN: 0195-668X

Journal article

de Boer SPM, Serruys PWJC, Valstar G, Lenzen MJ, de Jaegere PJ, Zijlstra F, Boersma E, van Domburg RT, interventional cardiologists of the Thoraxcentre 1980 to 1985et al., 2013, Life-years gained by smoking cessation after percutaneous coronary intervention., Am J Cardiol, Vol: 112, Pages: 1311-1314

Previous studies have shown that smoking cessation after a cardiac event reduces the risk of subsequent mortality in patients. The aim of this study was to describe the effect of smoking cessation in terms of prolonged life-years gained. The study sample comprised 856 patients who underwent percutaneous coronary intervention (PCI; balloon angioplasty) during 1980 to 1985. Patients were followed up for 30 years and smoking status at 1 year could be retrieved in 806 patients. The 27 patients who died within 1 year were excluded from the analysis. The median follow-up was 19.5 years (interquartile range 6.0 to 23.0). Cumulative 30-year survival rate was 29% in the group of patients who quit smoking and 14% in persistent smokers (p = 0.005). After adjustment for baseline characteristics at the time of PCI, smoking cessation remained an independent predictor of lesser mortality (adjusted hazard ratio 0.57, 95% confidence interval 0.46 to 0.71). The estimated life expectancy was 18.5 years in those who quit smoking and 16.4 years in the persistent smokers (p <0.0001). In conclusion, in patients with coronary heart disease who underwent PCI in the late 1980s, smoking cessation resulted in at least 2.1 life-years gained.

Journal article

Papafaklis MI, Bourantas CV, Farooq V, Diletti R, Muramatsu T, Zhang Y, Fotiadis DI, Onuma Y, Garcia HMG, Michalis LK, Serruys PWet al., 2013, In vivo assessment of the three-dimensional haemodynamic micro-environment following drug-eluting bioresorbable vascular scaffold implantation in a human coronary artery: fusion of frequency domain optical coherence tomography and angiography, EUROINTERVENTION, Vol: 9, Pages: 890-890, ISSN: 1774-024X

Journal article

Iqbal J, Serruys PW, Taggart DP, 2013, Optimal revascularization for complex coronary artery disease, NATURE REVIEWS CARDIOLOGY, Vol: 10, Pages: 635-647, ISSN: 1759-5002

Journal article

Mylotte D, Osnabrugge RLJ, Windecker S, Lefevre T, De Jaegere P, Jeger R, Wenaweser P, Maisano F, Moat N, Sondergaard L, Bosmans J, Teles RC, Martucci G, Manoharan G, Garcia EJ, Van Mieghem NM, Kappetein AP, Serruys PW, Lange R, Piazza Net al., 2013, Transcatheter Aortic Valve Replacement in Europe: The 2013 Update, 25th Annual Symposium on Transcatheter Cardiovascular Therapeutics (TCT), Publisher: ELSEVIER SCIENCE INC, Pages: B229-B229, ISSN: 0735-1097

Conference paper

Farooq V, Serruys PW, Vranckx P, Bourantas CV, Girasis C, Holmes DR, Kappetein AP, Mack M, Feldman T, Morice MC, Colombo A, Morel M-A, de Vries T, Dawkins KD, Mohr FW, James S, Stahle Eet al., 2013, Incidence, correlates, and significance of abnormal cardiac enzyme rises in patients treated with surgical or percutaneous based revascularisation A substudy from the Synergy between Percutaneous Coronary Interventions with Taxus and Cardiac Surgery (SYNTAX) Trial, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 5287-5292, ISSN: 0167-5273

Journal article

de Waha A, Stefanini GG, King LA, Byrne RA, Serruys PW, Kufner S, Meier B, Jueni P, Kastrati A, Windecker Set al., 2013, Long-term outcomes of biodegradable polymer versus durable polymer drug-eluting stents in patients with diabetes a pooled analysis of individual patient data from 3 randomized trials, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 5162-5166, ISSN: 0167-5273

Journal article

Widimsky P, Motovska Z, Belardi J, Serruys P, Silber S, Windecker S, Neumann F-Jet al., 2013, Long-term outcomes of patients receiving zotarolimus-eluting stents in ST elevation myocardial infarction, non-ST elevation acute coronary syndrome, and stable angina: Data from the Resolute program, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 3522-3526, ISSN: 0167-5273

Journal article

Brugaletta S, Sabate M, Martin-Yuste V, Masotti M, Shiratori Y, Alvarez-Contreras L, Cequier A, Iniguez A, Serra A, Hernandez-Antolin R, Mainar V, Valgimigli M, Tespili M, den Heijer P, Bethencourt A, Vazquez N, Gomez-Lara J, Backx B, Serruys PWet al., 2013, Predictors and clinical implications of stent thrombosis in patients with ST-segment elevation myocardial infarction Insights from the EXAMINATION trial, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 2632-2636, ISSN: 0167-5273

Journal article

Zhang Y-J, Xu B, Serruys PW, Bourantas CV, Iqbal J, Muramatsu T, Li M-H, Ye F, Tian N-L, Garcia-Garcia HM, Chen S-Let al., 2013, Radial approach for patients with ST-segment elevation acute coronary syndrome: It is definitely the best access site, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 3140-3142, ISSN: 0167-5273

Journal article

Shiratori Y, Brugaletta S, Alvarez-Contreras L, Azpeitia Y, Ospino N, Gaido S, Delahanty A, Santos A, Martin-Yuste V, Masotti M, Serruys PW, Windecker S, Sabate Met al., 2013, One-Year Head to Head Comparison of the Neointimal Response Between Sirolimus Eluting Stent with Reservoir Technology and Everolimus Eluting Stent: An Optical Coherence Tomography Study, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 82, Pages: E428-E436, ISSN: 1522-1946

Journal article

Onuma Y, Dudek D, Thuesen L, Webster M, Nieman K, Garcia-Garcia HM, Ormiston JA, Serruys PWet al., 2013, Five-Year Clinical and Functional Multislice Computed Tomography Angiographic Results After Coronary Implantation of the Fully Resorbable Polymeric Everolimus-Eluting Scaffold in Patients With De Novo Coronary Artery Disease, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 6, Pages: 999-1009, ISSN: 1936-8798

Journal article

Gogas BD, Bourantas CV, Garcia-Garcia HM, Onuma Y, Muramatsu T, Farooq V, Diletti R, van Geuns R-JM, De Bruyne B, Chevalier B, Thuesen L, Smits PC, Dudek D, Koolen J, Windecker S, Whitbourn R, McClean D, Dorange C, Miquel-Hebert K, Veldhof S, Rapoza R, Ormiston JA, Serruys PWet al., 2013, The edge vascular response following implantation of the Absorb everolimus-eluting bioresorbable vascular scaffold and the XIENCE V metallic everolimus-eluting stent. First serial follow-up assessment at six months and two years: insights from the first-in-man ABSORB Cohort B and SPIRIT II trials., EuroIntervention, Vol: 9, Pages: 709-720

AIMS: To assess serially the edge vascular response (EVR) of a bioresorbable vascular scaffold (BVS) compared to a metallic everolimus-eluting stent (EES). METHODS AND RESULTS: Non-serial evaluations of the Absorb BVS at one year have previously demonstrated proximal edge constrictive remodelling and distal edge changes in plaque composition with increase of the percent fibro-fatty (FF) tissue component. The 5 mm proximal and distal segments adjacent to the implanted devices were investigated serially with intravascular ultrasound (IVUS), post procedure, at six months and at two years, from the ABSORB Cohort B1 (n=45) and the SPIRIT II (n=113) trials. Twenty-two proximal and twenty-four distal edge segments were available for analysis in the ABSORB Cohort B1 trial. In the SPIRIT II trial, thirty-three proximal and forty-six distal edge segments were analysed. At the 5-mm proximal edge, the vessels treated with an Absorb BVS from post procedure to two years demonstrated a lumen loss (LL) of 6.68% (-17.33; 2.08) (p=0.027) with a trend toward plaque area increase of 7.55% (-4.68; 27.11) (p=0.06). At the 5-mm distal edge no major changes were evident at either time point. At the 5-mm proximal edge the vessels treated with a XIENCE V EES from post procedure to two years did not show any signs of LL, only plaque area decrease of 6.90% (-17.86; 4.23) (p=0.035). At the distal edge no major changes were evident with regard to either lumen area or vessel remodelling at the same time point. CONCLUSIONS: The IVUS-based serial evaluation of the EVR up to two years following implantation of a bioresorbable everolimus-eluting scaffold shows a statistically significant proximal edge LL; however, this finding did not seem to have any clinical implications in the serial assessment. The upcoming imaging follow-up of the Absorb BVS at three years is anticipated to provide further information regarding the vessel wall behaviour at the edges.

Journal article

L├╝scher TF, de Feyter P, Sabate M, Van Mieghem NM, Mahfoud F, Serruys PWet al., 2013, The European Heart Journal and EuroIntervention: information and education in interventional cardiology., EuroIntervention, Vol: 9, Pages: 669-680

Journal article

Cummins P, Serruys PW, 2013, ESC Journals working together., EuroIntervention, Vol: 9

Journal article

Ruzsa Z, van der Linden M, Van Mieghem NM, Regar E, Ligthart JM, Serruys P, van Geuns RJet al., 2013, Culotte stenting with bioabsorbable everolimus-eluting stents, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: E35-E37, ISSN: 0167-5273

Journal article

van der Boon RMA, Van Mieghem NM, Theuns DA, Nuis R-J, Nauta ST, Serruys PW, Jordaens L, van Domburg RT, de Jaegere PPTet al., 2013, Pacemaker dependency after transcatheter aortic valve implantation with the self-expanding Medtronic CoreValve System, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 1269-1273, ISSN: 0167-5273

Journal article

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