Imperial College London

ProfessorPatrickSerruys

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

p.serruys

 
 
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Location

 

c/o Prof Kim FoxGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Serruys:2008:10.4244/eijv3i5a108,
author = {Serruys, PW and Vranckx, P and Slagboom, T and Regar, E and Meliga, E and de, Winter RJ and Heyndrickx, G and Schuler, G and van, Remortel EA and Dubé, GP and Symons, J},
doi = {10.4244/eijv3i5a108},
journal = {EuroIntervention},
pages = {600--609},
title = {Haemodynamic effects, safety, and tolerability of haemoglobin-based oxygen carrier-201 in patients undergoing PCI for CAD.},
url = {http://dx.doi.org/10.4244/eijv3i5a108},
volume = {3},
year = {2008}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - AIMS: Haemoglobin based oxygen carriers (HBOCs) are considered in the treatment of patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention (PCI). In light of their potential vasopressor and colloidal properties, their effect on coronary physiology, safety and tolerability needs to be established. METHODS AND RESULTS: In this phase II pilot trial, 45 patients were randomly assigned, (1:1:1) to double blind treatment with a 30 minute intravenous (IV) infusion of either 15 or 30 g of HBOC-201, compared to an equivalent volume of non-oxygen carrier colloid control. Systemic, pulmonary, and coronary haemodynamics were studied during this infusion period. IV HBOC-201 administration produced an increase in systolic blood pressure (SBP), pulmonary capillary wedge pressure and calculated systemic vascular resistance (SVR) and a concomitant decrease in cardiac output (CO); there was a decrease in mixed venous saturation (SVO2) following IV HBOC-201. The left ventricular stroke work index (LVSWI) was not altered by HBOC-201 treatment. Of note, no coronary vasoconstriction was observed, nor were there significant changes in resting average peak velocity (APV), coronary-artery diameter, volumetric coronary blood flow, or coronary vascular resistance. The percentage of patients with adverse events did not differ between the HBOC-201 treated and control groups (76% vs. 63%, respectively, P=0.49). Seven serious adverse events (SAE) occurred in six patients in the treatment group and two in two patients in the control group. Only one SAE (hypertension) was judged HBOC-201 related. Patients in both the HBOC-201 and control group had a similar incidence of increased liver alanine transaminase (31% vs 31%, respectively, NS); 10% of the patients in the HBOC-201 group had increases greater than three times the upper limit of normal. Differential increases were noticed in some inflammatory markers (IL-6, CRP) 18-24 hours after infusion between the HBOC-2
AU - Serruys,PW
AU - Vranckx,P
AU - Slagboom,T
AU - Regar,E
AU - Meliga,E
AU - de,Winter RJ
AU - Heyndrickx,G
AU - Schuler,G
AU - van,Remortel EA
AU - Dubé,GP
AU - Symons,J
DO - 10.4244/eijv3i5a108
EP - 609
PY - 2008///
SN - 1774-024X
SP - 600
TI - Haemodynamic effects, safety, and tolerability of haemoglobin-based oxygen carrier-201 in patients undergoing PCI for CAD.
T2 - EuroIntervention
UR - http://dx.doi.org/10.4244/eijv3i5a108
UR - https://www.ncbi.nlm.nih.gov/pubmed/19608488
VL - 3
ER -