Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Visiting Professor







c/o Prof Kim FoxGuy Scadding BuildingRoyal Brompton Campus






BibTex format

author = {Radu, MD and Räber, L and Heo, J and Gogas, BD and Jørgensen, E and Kelbæk, H and Muramatsu, T and Farooq, V and Helqvist, S and Garcia-Garcia, HM and Windecker, S and Saunamäki, K and Serruys, PW},
doi = {10.4244/EIJV9I9A183},
journal = {EuroIntervention},
pages = {1085--1094},
title = {Natural history of optical coherence tomography-detected non-flow-limiting edge dissections following drug-eluting stent implantation.},
url = {},
volume = {9},
year = {2014}

RIS format (EndNote, RefMan)

AB - AIMS: Angiographic evidence of edge dissections has been associated with a risk of early stent thrombosis. Optical coherence tomography (OCT) is a high-resolution technology detecting a greater number of edge dissections--particularly non-flow-limiting--compared to angiography. Their natural history and clinical implications remain unclear. The objectives of the present study were to assess the morphology, healing response, and clinical outcomes of OCT-detected edge dissections using serial OCT imaging at baseline and at one year following drug-eluting stent (DES) implantation. METHODS AND RESULTS: Edge dissections were defined as disruptions of the luminal surface in the 5 mm segments proximal and distal to the stent, and categorised as flaps, cavities, double-lumen dissections or fissures. Qualitative and quantitative OCT analyses were performed every 0.5 mm at baseline and one year, and clinical outcomes were assessed. Sixty-three lesions (57 patients) were studied with OCT at baseline and one-year follow-up. Twenty-two non-flow-limiting edge dissections in 21 lesions (20 patients) were identified by OCT; only two (9%) were angiographically visible. Flaps were found in 96% of cases. The median longitudinal dissection length was 2.9 mm (interquartile range [IQR] 1.6-4.2 mm), whereas the circumferential and axial extensions amounted to 1.2 mm (IQR: 0.9-1.7 mm) and 0.6 mm (IQR: 0.4-0.7 mm), respectively. Dissections extended into the media and adventitia in seven (33%) and four (20%) cases, respectively. Eighteen (82%) OCT-detected edge dissections were also evaluated with intravascular ultrasound which identified nine (50%) of these OCT-detected dissections. No stent thrombosis or target lesion revascularisation occurred up to one year. At follow-up, 20 (90%) edge dissections were completely healed on OCT. The two cases exhibiting persistent dissection had the longest flaps (2.81 mm and 2.42 mm) at baseline. CONCLUSIONS: OCT-detected edge dissections which are angi
AU - Radu,MD
AU - Räber,L
AU - Heo,J
AU - Gogas,BD
AU - Jørgensen,E
AU - Kelbæk,H
AU - Muramatsu,T
AU - Farooq,V
AU - Helqvist,S
AU - Garcia-Garcia,HM
AU - Windecker,S
AU - Saunamäki,K
AU - Serruys,PW
DO - 10.4244/EIJV9I9A183
EP - 1094
PY - 2014///
SP - 1085
TI - Natural history of optical coherence tomography-detected non-flow-limiting edge dissections following drug-eluting stent implantation.
T2 - EuroIntervention
UR -
UR -
VL - 9
ER -