Imperial College London

ProfessorPatrickSerruys

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

p.serruys

 
 
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Location

 

c/o Prof Kim FoxGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{de:2013:10.1016/j.ijcard.2013.09.011,
author = {de, Boer SPM and van, Leeuwen MAH and Cheng, JM and Oemrawsingh, RM and van, Geuns R-J and Serruys, PWJC and Boersma, E and Lenzen, MJ},
doi = {10.1016/j.ijcard.2013.09.011},
journal = {Int J Cardiol},
pages = {305--310},
title = {Trial participation as a determinant of clinical outcome: differences between trial-participants and Every Day Clinical Care patients in the field of interventional cardiology.},
url = {http://dx.doi.org/10.1016/j.ijcard.2013.09.011},
volume = {169},
year = {2013}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BACKGROUND: This study examines differences in clinical outcome between trial-participants and non-participants after percutaneous coronary intervention (PCI). METHODS AND RESULTS: This study compromised of 11,931 consecutive patients who underwent PCI in a high volume center, during the period 2000 - 2009. Of these patients, 1787 (15%) participated in an interventional clinical trial with a follow-up period of at least six months. The maximum follow-up duration was 11.8 years, with a median of 3.8 years (IQR: 2.6 - 6.5). Baseline and procedural characteristics differed between trial-participants and non-participants. Trial-participants were more often male, were younger, had more cardiovascular risk factors and were treated more often for stable angina pectoris and single vessel disease. Overall mortality at maximum follow-up was lower for trial-participants compared to non-participants (8.1% versus 17.6%, p<0.001, adjusted HR, 0.62, 95% CI: 0.52-0.74). There was no difference in the incidence of non-fatal MI and CABG. Repeat PCI was seen more often in trial-participants (18.1% versus 30.7%, p<0.001, adjusted HR 1.91, 95%CI 1.73-2.10). Consequently, a higher incidence of the composite of mortality, repeat revascularization, and non-fatal MI was seen in the trail-participants (adjusted HR.1.36 95% CI 1.25 - 1.47), but this association was primarily driven by the occurrence of repeat PCI. CONCLUSION: Participants in clinical trials in the field of interventional cardiology with a follow-up of at least six months differed considerably from non-participants in baseline and procedural characteristics. Trial-participants had better survival than non-participants. In contrast, a two-fold higher incidence of repeat PCI was observed in trial-participants.
AU - de,Boer SPM
AU - van,Leeuwen MAH
AU - Cheng,JM
AU - Oemrawsingh,RM
AU - van,Geuns R-J
AU - Serruys,PWJC
AU - Boersma,E
AU - Lenzen,MJ
DO - 10.1016/j.ijcard.2013.09.011
EP - 310
PY - 2013///
SP - 305
TI - Trial participation as a determinant of clinical outcome: differences between trial-participants and Every Day Clinical Care patients in the field of interventional cardiology.
T2 - Int J Cardiol
UR - http://dx.doi.org/10.1016/j.ijcard.2013.09.011
UR - https://www.ncbi.nlm.nih.gov/pubmed/24144926
VL - 169
ER -