Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Visiting Professor







c/o Prof Kim FoxGuy Scadding BuildingRoyal Brompton Campus






BibTex format

author = {Simsek, C and Karanasos, A and Magro, M and Garcia-Garcia, HM and Onuma, Y and Regar, E and Boersma, E and Serruys, PW and van, Geuns RJ},
doi = {10.4244/EIJY14M10_12},
journal = {Eurointervention},
pages = {996--1003},
title = {Long-term invasive follow-up of the everolimus-eluting bioresorbable vascular scaffold: five-year results of multiple invasive imaging modalities},
url = {},
volume = {11},
year = {2016}

RIS format (EndNote, RefMan)

AB - AIMS: Invasive imaging modalities have shown restoration of vasomotion, prevention of restenosis and, most importantly, increase in lumen area between six months and two years after first-generation everolimus-eluting bioresorbable vascular scaffold (Absorb BVS) implantation. Our aim was to assess whether these positive findings were sustained in the long term. METHODS AND RESULTS: Patients included in the ABSORB cohort A from the Thoraxcenter Rotterdam cohort underwent coronary catheterisation including angiography, intravascular ultrasound (IVUS), virtual histology, optical coherence tomography (OCT) and vasomotion testing at five years. Eight out of 16 patients underwent catheterisation and scaffold assessment with multiple imaging modalities. A trend towards an increase in minimum luminal diameter was observed between two and five years by angiography (1.95±0.37 mm vs. 2.14±0.38 mm; p=0.09). IVUS data showed an increase in mean lumen area at five years (6.96±1.13 mm2) compared to six months (6.17±0.74 mm2; p=0.06) and two years (6.56±1.16 mm2; p=0.12), primarily due to a persistent reduction in plaque area size between six months and five years (9.17±1.86 mm2 vs. 7.57±1.63 mm2; p=0.03). The necrotic core area was reduced at five years compared to post-procedural results. In OCT, an increase in mean and minimal luminal area was observed. Moreover, no scaffold struts could be identified and a smooth endoluminal lining was observed. The scaffolded coronary segment did not show signs of endothelial dysfunction with acetylcholine testing. CONCLUSIONS: At five years, the Absorb BVS is no longer discernible by any invasive imaging method and endothelial function is restored. Late luminal enlargement persists up to five years of follow-up without adaptive vessel remodelling.
AU - Simsek,C
AU - Karanasos,A
AU - Magro,M
AU - Garcia-Garcia,HM
AU - Onuma,Y
AU - Regar,E
AU - Boersma,E
AU - Serruys,PW
AU - van,Geuns RJ
DO - 10.4244/EIJY14M10_12
EP - 1003
PY - 2016///
SN - 1969-6213
SP - 996
TI - Long-term invasive follow-up of the everolimus-eluting bioresorbable vascular scaffold: five-year results of multiple invasive imaging modalities
T2 - Eurointervention
UR -
VL - 11
ER -