Imperial College London

ProfessorPatrickSerruys

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

p.serruys

 
 
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Location

 

c/o Prof Kim FoxGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Oemrawsingh:2016:10.4244/EIJY15M07_04,
author = {Oemrawsingh, RM and Cheng, JM and Akkerhuis, KM and Kardys, I and Degertekin, M and van, Geuns RJ and Daemen, J and Boersma, E and Serruys, PW and van, Domburg RT},
doi = {10.4244/EIJY15M07_04},
journal = {Eurointervention},
pages = {345--351},
title = {High-sensitivity C-reactive protein predicts 10-year cardiovascular outcome after percutaneous coronary intervention},
url = {http://dx.doi.org/10.4244/EIJY15M07_04},
volume = {12},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - AIMS: This study aimed to evaluate the prognostic value of high-sensitivity C-reactive protein (hsCRP) during 10-year follow-up after percutaneous coronary intervention (PCI). METHODS AND RESULTS: Between April and October 2002, hsCRP was measured in 468 all-comer patients who underwent PCI with sirolimus-eluting stent implantation for stable coronary artery disease or acute coronary syndrome. The primary endpoint was the composite of all-cause mortality or myocardial infarction at 10-year follow-up. Kaplan-Meier event curves displayed ongoing divergence of the hsCRP groups (hsCRP <1 mg/L: 14.7% vs. 1-3 mg/L: 31.1% vs. >3 mg/L: 43.1%). After adjustment for established cardiovascular risk factors and clinical presentation in a Cox regression model, higher CRP levels were associated with a higher incidence of the composite endpoint (>3 mg/L vs. <1 mg/L: HR 2.87, 95% CI: 1.69-4.87, p<0.001; 1-3 mg/L vs. <1 mg/L: HR 2.30, 95% CI: 1.31-4.03, p=0.004). Although adding hsCRP to a prediction model containing conventional cardiovascular risk factors did not significantly improve discriminatory power (area under the receiver operating characteristic curve 0.71 to 0.73, p=0.56), hsCRP was able to improve risk classification (net reclassification index=0.40, p=<0.001). CONCLUSIONS: In patients undergoing PCI, higher CRP levels at the time of the procedure are predictive for 10-year mortality and myocardial infarction. High-sensitivity CRP may be a useful biomarker to improve further risk assessment in patients undergoing PCI.
AU - Oemrawsingh,RM
AU - Cheng,JM
AU - Akkerhuis,KM
AU - Kardys,I
AU - Degertekin,M
AU - van,Geuns RJ
AU - Daemen,J
AU - Boersma,E
AU - Serruys,PW
AU - van,Domburg RT
DO - 10.4244/EIJY15M07_04
EP - 351
PY - 2016///
SN - 1969-6213
SP - 345
TI - High-sensitivity C-reactive protein predicts 10-year cardiovascular outcome after percutaneous coronary intervention
T2 - Eurointervention
UR - http://dx.doi.org/10.4244/EIJY15M07_04
VL - 12
ER -