Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Visiting Professor







c/o Prof Kim FoxGuy Scadding BuildingRoyal Brompton Campus






BibTex format

author = {Sotomi, Y and Tateishi, H and Suwannasom, P and Dijkstra, J and Eggermont, J and Liu, S and Tenekecioglu, E and Zheng, Y and Abdelghani, M and Cavalcante, R and de, Winter RJ and Wykrzykowska, JJ and Onuma, Y and Serruys, PW and Kimura, T},
doi = {10.1007/s10554-016-0856-6},
journal = {International Journal of Cardiovascular Imaging},
pages = {871--883},
title = {Quantitative assessment of the stent/scaffold strut embedment analysis by optical coherence tomography},
url = {},
volume = {32},
year = {2016}

RIS format (EndNote, RefMan)

AB - The degree of stent/scaffold embedment could be a surrogate parameter of the vessel wall-stent/scaffold interaction and could have biological implications in the vascular response. We have developed a new specific software for the quantitative evaluation of embedment of struts by optical coherence tomography (OCT). In the present study, we described the algorithm of the embedment analysis and its reproducibility. The degree of embedment was evaluated as the ratio of the embedded part versus the whole strut height and subdivided into quartiles. The agreement and the inter- and intra-observer reproducibility were evaluated using the kappa and the interclass correlation coefficient (ICC). A total of 4 pullbacks of OCT images in 4 randomly selected coronary lesions with 3.0 × 18 mm devices [2 lesions with Absorb BVS and 2 lesions with XIENCE (both from Abbott Vascular, Santa Clara, CA, USA)] from Absorb Japan trial were evaluated by two investigators with QCU-CMS software version 4.69 (Leiden University Medical Center, Leiden, The Netherlands). Finally, 1481 polymeric struts in 174 cross-sections and 1415 metallic struts in 161 cross-sections were analyzed. Inter- and intra-observer reproducibility of quantitative measurements of embedment ratio and categorical assessment of embedment in Absorb BVS and XIENCE had excellent agreement with ICC ranging from 0.958 to 0.999 and kappa ranging from 0.850 to 0.980. The newly developed embedment software showed excellent reproducibility. Computer-assisted embedment analysis could be a feasible tool to assess the strut penetration into the vessel wall that could be a surrogate of acute injury caused by implantation of devices.
AU - Sotomi,Y
AU - Tateishi,H
AU - Suwannasom,P
AU - Dijkstra,J
AU - Eggermont,J
AU - Liu,S
AU - Tenekecioglu,E
AU - Zheng,Y
AU - Abdelghani,M
AU - Cavalcante,R
AU - de,Winter RJ
AU - Wykrzykowska,JJ
AU - Onuma,Y
AU - Serruys,PW
AU - Kimura,T
DO - 10.1007/s10554-016-0856-6
EP - 883
PY - 2016///
SN - 1875-8312
SP - 871
TI - Quantitative assessment of the stent/scaffold strut embedment analysis by optical coherence tomography
T2 - International Journal of Cardiovascular Imaging
UR -
UR -
VL - 32
ER -