Imperial College London

DR PALLAB SETH

Faculty of MedicineDepartment of Brain Sciences

Editorial Manager
 
 
 
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Contact

 

+44 (0)20 7594 6648p.seth

 
 
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Location

 

E 511Burlington DanesHammersmith Campus

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Summary

 

Overview

Research Skill

  1. In vitro and in vivo electrophysiology and classical pharmacology.
  2. Electrophysiological recording of different spinal cord potentials (Monosynaptic reflex, polysynaptic reflex, dorsal root reflex) from spinal cord of rat under in vivo condition.
  3. Electrophysiological recording of A- and C- fibre activity from spinal cord of rat under in vivo condition using single fibre technique.
  4. Extracellular microelectrode recording of single cell (i.e., Renshaw cell interneurone) from spinal cord of rat under in vivo condition.
  5. Electrophysiological recording of nerve action potential, nerve stimulated muscle action potential, nerve stimulated isometric tension of the muscle as well as directly muscle stimulated muscle action potential and muscle tension responses from different isolated nerve-muscle (e.g., hemidiaphragm, soleus, EDL) preparation with in vitro EMG chamber.
  6. Intracellular microelectrode recording of MEPP from muscle end plate of phrenic nerve-hemidiaphragm preparation in vitro.
  7. Computer handling for on-line electrophysiological data analyses (i.e., Origin, Transition etc.), various statistical and office packages.
  8. Behavioural Neuropharmacology: Research experience on different neurobehavioural tests to detect anxiety and stress responses in animals (Social interaction test, Elevated plus maze test etc.).

PUBLICATIONS

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Editorial

Houghton PJ, Seth P. Plants and the central nervous system. Pharmacol Biochem Behav. 2003;75:497-499.

Review Articles

1. File SE, Seth P. A review of 25 years of the social interaction test. Eur J Pharmacol. 2003;463:35-53.
2. Seth P, Cheeta S, Tucci S, File SE. Nicotinic--serotonergic interactions in brain and behaviour. Pharmacol Biochem Behav. 2002;71:795-805. 

Original Research Articles

1. Elsabagh S, Hartley DE, Randall DC, Seth P, File SE. Mood changes after cognitive testing in late middle-age: impacts of sex and habitual alcohol consumption. Pharmacol Biochem Behav 2004;78:621-628.
2. Hartley DE, Edwards JE, Spiller CE, Alom N, Tucci S, Seth P, Forsling ML, File SE. The soya isoflavone content of rat diet can increase anxiety and stress hormone release in the male rat. Psychopharmacology 2003;167:46-53.
3. Tucci S, Cheeta S, Seth P, File SE. Corticotropin releasing factor antagonist, -helical CRF9-41, reverses nicotine-induced conditioned, but not unconditioned, anxiety. Psychopharmacology 2003;167:251-256.
4. Tucci S, Cheeta S, Genn RF, Seth P, File SE. Anxiety conditioned to nicotine in the elevated plus-maze is time dependent. Behav Pharmacol. 2002;13:615-620.
5. Gupta S, Chaudhuri T, Seth P, Ganguly DK, Giri AK. Antimutagenic effects of black tea (World Blend) and its two active polyphenols theaflavins and thearubigins in Salmonella assays. Phytother Res. 2002;16:655-661.
6. Chaudhuri L, Basu S, Seth P, Chaudhuri T, Besra SE, Vedasiromoni JR, Ganguly DK. Prokinetic effect of black tea on gastrointestinal motility. Life Sci. 2000;66:847-854.
7. Seth P, Gajendiran M, Ganguly DK. Desensitization of spinal 5-HT1A receptors to 8-OH-DPAT: an in vivo spinal reflex study. Neuroreport 1997;8:2489-2493.
8. Gajendiran M, Seth P, Ganguly DK. Involvement of the presynaptic dopamine D2 receptor in the depression of spinal reflex by apomorphine. Neuroreport 1996;7:513-516.
9. Seth P, Gajendiran M, Maitra KK, Ross HG, Ganguly DK. Evidence for D1 dopamine receptor-mediated modulation of the synaptic transmission from motor axon collaterals to Renshaw cells in the rat spinal cord. Neurosci Lett. 1993;158:217-220.
10. Maitra KK, Seth P, Thewissen M, Ross HG, Ganguly DK. Dopaminergic influence on the excitability of antidromically activated Renshaw cells in the lumbar spinal cord of the rat. Acta Physiol Scand. 1993;148:101-107.
11. Maitra KK, Seth P, Ross HG, Thewissen M, Ganguly DK. Presynaptic dopaminergic inhibition of the spinal reflex in rats. Brain Res Bull. 1992;28:817-819.
12. Maitra KK, Seth P, Mohanakumar KP, Ganguly DK. Supersensitivity of spinal dopaminergic receptors in rat after chronic haloperidol. Brain Res Bull. 1992;28:133-135.
13. Seth P, Maitra KK, Ganguly DK. Haloperidol on rat phrenic hemidiaphragm. Arch Int Pharmacodyn Ther. 1991;310:87-93.

AWARDS AND HONOURS

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1994 Uvnas Prize, Indian Pharmacological Society (for best published paper on biogenic amines in 1993 by a member of the society; paper published in Neuroscience Letters)

1997  IUPS Fellowship from International Union of Physiological Sciences, France (for attending 33rd International Congress of Physiological Sciences, St. Petersburg, Russia)

2001 IBRO Travel Grants from International Brain Research Organisation, France (for attending 34th International Congress of Physiological Sciences, Christchurch, New Zealand)

2003 Guest Editor, Special Issue on  'Plants and the Central Nervous System' (Pharmacology, Biochemistry and Behavior)

2009   Guest Editor, Special Issue on  'Steroid Hormones, Neuropeptides, and Brain Function' (Journal of Neuroendocrinology)